Results 21 to 30 of about 11,568 (219)
Modulation of Transient Receptor Potential C Channel Activity by Cholesterol
Frontiers in Pharmacology, 2019 Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov +6 more
doaj +1 more source
Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
doaj +1 more source
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells
Cells, 2020 Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information.
Alberto Arboit +2 more
doaj +1 more source
TRPC channels in exercise-mimetic therapy [PDF]
Pflügers Archiv - European Journal of Physiology, 2018 Physical exercise yields beneficial effects on all types of muscle cells, which are essential for the maintenance of cardiovascular homeostasis and good blood circulation. Daily moderate exercise increases systemic antioxidative capacity, which can lead to the prevention of the onset and progression of oxidative stress-related diseases.
Takuro Numaga-Tomita +5 more
openaire +2 more sources
TRPC Channels and Parkinson’s Disease [PDF]
, 2017 Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling ...
Pramod, Sukumaran +4 more
openaire +2 more sources
Expression and function of transient receptor potential channels in the female bovine reproductive tract [PDF]
, 2016 © 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions.
Atkin, Stephen L. +3 more
core +2 more sources
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy [PDF]
, 2014 Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology.
Andersen, Asger +13 more
core +1 more source
How TRPC Channels Modulate Hippocampal Function [PDF]
International Journal of Molecular Sciences, 2020 Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions.
Roberta Gualdani, Philippe Gailly
openaire +3 more sources
PLoS ONE, 2011 Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner +7 more
doaj +1 more source
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. [PDF]
PLoS ONE, 2012 BACKGROUND: Members of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli.
Farhath Badsha +6 more
doaj +1 more source