TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
doaj +1 more source
Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
Cells, 2021 This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley +3 more
doaj +1 more source
Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex. [PDF]
J Neurosci, 2018 Continuation of spiking after a stimulus ends (i.e. persistent spiking) is thought to support working memory. Muscarinic receptor activation enables persistent spiking among synaptically isolated pyramidal neurons in anterior cingulate cortex (ACC), but ...
Ratté S, Karnup S, Prescott SA.
europepmc +2 more sources
TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
Frontiers in Neuroscience, 2021 Leptin regulates hypothalamic POMC+ (pro-opiomelanocortin) neurons by inducing TRPC (Transient Receptor Potential Cation) channel-mediate membrane depolarization.
Paula P. Perissinotti +2 more
doaj +1 more source
Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes
Biomolecules, 2023 An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen +6 more
doaj +1 more source
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine [PDF]
, 2022 Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC channels are thought to act as complex integrators of physical and chemical environmental
Bon, RS +3 more
core +1 more source
Molecular Metabolism, 2022 Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic ...
Jian Qiu +6 more
doaj +1 more source
Modulation of Transient Receptor Potential C Channel Activity by Cholesterol
Frontiers in Pharmacology, 2019 Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov +6 more
doaj +1 more source
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]
, 2008 The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N. +5 more
core +1 more source
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells
Cells, 2020 Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information.
Alberto Arboit +2 more
doaj +1 more source