Inhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroids. [PDF]
PLoS ONE, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca(2+) signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Susanne Miehe +8 more
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Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation. [PDF]
PLoS ONE, 2011 Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner +7 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease [PDF]
Cells, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Débora Falcón +7 more
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Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway [PDF]
Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
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TRPC channels as STIM1-regulated store-operated channels [PDF]
Cell Calcium, 2007 Receptor-activated Ca(2+) influx is mediated largely by store-operated channels (SOCs). TRPC channels mediate a significant portion of the receptor-activated Ca(2+) influx. However, whether any of the TRPC channels function as a SOC remains controversial.
Paul F, Worley +6 more
openaire +4 more sources
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels [PDF]
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
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Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen +4 more
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Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells [PDF]
Scientific ReportsDiethylcarbamazine is a classic anthelmintic that is used for the prevention and treatment of lymphatic filariasis. The mode of action of diethylcarbamazine is still not well understood with the consensus that it acts on the host immune system, rather ...
Paul D. E. Williams +3 more
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TRPC channel activation and pharmacology
, 2015 Ion channel permeability and calcium ion (Ca2+) signalling are essential in regulating cellular responses to external and internal stimuli. Changes in the Ca2+ signalling machinery during pathologies of the cardiovascular system are a common occurrence ...
Moss, Nicholas Keith
core +8 more sources
Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases [PDF]
Jichu yixue yu linchuang, 2023 Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells.
XIE Dongge, LI Junhao, HAN Han, LI Shoutian
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