Results 11 to 20 of about 6,662 (179)
TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
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TRPC Channels in Proteinuric Kidney Diseases [PDF]
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall +2 more
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Molecular Metabolism, 2022 Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic ...
Jian Qiu +6 more
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Modulation of Transient Receptor Potential C Channel Activity by Cholesterol
Frontiers in Pharmacology, 2019 Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov +6 more
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Frontiers in Pharmacology, 2015 Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori +6 more
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Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells
Cells, 2020 Persistent neural activity has been observed in vivo during working memory tasks, and supports short-term (up to tens of seconds) retention of information.
Alberto Arboit +2 more
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TRPC Channels and Parkinson’s Disease [PDF]
, 2017 Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling ...
Pramod, Sukumaran +4 more
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PLoS ONE, 2011 Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Kristina Leuner +7 more
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Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. [PDF]
PLoS ONE, 2012 BACKGROUND: Members of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli.
Farhath Badsha +6 more
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The integrative function of TRPC channels
Frontiers in Bioscience, 2009 TRPC is a subfamily of Transient Receptor Potential channels that have the highest degree of homology to the Drosophila photoreceptors' TRP. TRPC open in response to stimulation of plasma membrane receptors that activate phospholipase C, triggering transmembrane Ca2+ influx.
Kirill, Kiselyov, Randen L, Patterson
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