Results 41 to 50 of about 1,209,942 (198)
TRPC Channels and their Implications for Neurological Diseases [PDF]
CNS & Neurological Disorders - Drug Targets, 2010 Calcium is an essential intracellular messenger and serves critical cellular functions in both excitable and non-excitable cells. Most of the physiological functions in these cells are uniquely regulated by changes in cytosolic Ca2+ levels ([Ca2+](i)), which are achieved via various mechanisms.
Senthil, Selvaraj +2 more
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Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. [PDF]
PLoS ONE, 2013 The canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable cationic channels controlling the Ca(2+) influx evoked by G protein-coupled receptor activation and/or by Ca(2+) store depletion. Here we investigate the involvement of TRPCs
Hong-Ni Jiang +6 more
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TRPC channel activation by extracellular thioredoxin [PDF]
Nature, 2008 Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identification of endogenous activators and the determination of cellular and tissue functions of these channels ...
Xu, Shang-Zhong +16 more
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TRPC channels as STIM1-regulated SOCs [PDF]
Channels, 2009 Store-operated Ca(2+) channels (SOCs) are Ca(2+) influx channels at the plasma membrane whose opening is determined by the level of Ca(2+) stored in the endoplasmic reticulum lumen. SOCs are activated in response to receptor-mediated or passive depletion of ER Ca(2+) to regulate many Ca(2+)-dependent cellular functions.
Joseph P, Yuan +6 more
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Cells, 2019 The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim +3 more
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A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. [PDF]
PLoS ONE, 2010 Store-operated Ca(2+) entry (SOCE) channels are the main pathway of Ca(2+) entry in non-excitable cells such as neural progenitor cells (NPCs). However, the role of SOCE channels has not been defined in the neuronal differentiation from NPCs.
Hye Young Shin +9 more
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Frontiers in Physiology, 2018 Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts.
Hairuo Wen +4 more
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Physiological Function and Characterization of TRPCs in Neurons
Cells, 2014 Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2 ...
Yuyang Sun +3 more
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eLife, 2023 Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception.
Ely Contreras +4 more
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TRPC channels in smooth muscle cells [PDF]
Frontiers in Bioscience, 2010 Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the ...
Jose C, Gonzalez-Cobos, Mohamed, Trebak
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