Results 51 to 60 of about 6,662 (179)
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 8, Page 5703-5719, August 2026.ABSTRACT Salinity stress disrupts rhizosphere homoeostasis and inhibits root development. Although PGPR are known to alleviate such stress, critical knowledge gaps remain regarding the specific mechanisms by which they enhance tolerance under moderate to high salinity, particularly within the wheat rhizosphere ‐root interface.
Fuqiang Zhu +10 more
wiley +1 more source
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.
PLoS Biology, 2019 Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the ...
Yvonne Schwarz +8 more
doaj +1 more source
Cancer Cell International, 2009 Background Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+.
Djamgoz Mustafa +3 more
doaj +1 more source
Optimization of photobiomodulation therapy for spinal cord injury: A review
Photochemistry and Photobiology, Volume 102, Issue 4, Page 797-831, July/August 2026.Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew +3 more
wiley +1 more source
BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. [PDF]
PLoS ONE, 2014 Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process of pulmonary arterial hypertension (PAH). BMP4 plays an important role during the process of pulmonary arterial remodeling and mutant of the principle ...
Yi Zhang +9 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou +7 more
wiley +1 more source
Cytoskeletal Regulation of TRPC Channels in the Cardiorenal System [PDF]
Current Hypertension Reports, 2012 Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac ...
Jonathan A, Stiber +3 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca2+, concentration ([Ca2+]i) and physiological significance of Na+ influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese ...
Takahiro Horinouchi +7 more
doaj +1 more source