Results 61 to 70 of about 6,662 (179)

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

TRPC3 Channels in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2017
Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF).
Takuro Numaga-Tomita, Takuro Numaga-Tomita, Sayaka Oda, Sayaka Oda, Tsukasa Shimauchi, Tsukasa Shimauchi, Akiyuki Nishimura, Akiyuki Nishimura, Supachoke Mangmool, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida, Motohiro Nishida   +12 more
doaj   +1 more source

Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. [PDF]

PLoS ONE, 2010
In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions.
Vesna Cvetkovic-Lopes, Emmanuel Eggermann, Aaron Uschakov, Jeremy Grivel, Laurence Bayer, Barbara E Jones, Mauro Serafin, Michel Mühlethaler   +7 more
doaj   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta. [PDF]

PLoS ONE, 2012
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family, and has been implicated both in embryogenesis and development of the CNS.
Fuwang Peng, Honghong Yao, Halis Kaan Akturk, Shilpa Buch   +3 more
doaj   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

The Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6

Frontiers in Aging Neuroscience, 2020
Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory.
Lu Liu, Lijuan Gu, Manli Chen, Yueying Zheng, Xiaoxing Xiong, Xiaoxing Xiong, Shengmei Zhu   +6 more
doaj   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, Volume 15, Issue 13, 3 April 2026.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

The closing and opening of TRPC channels by Homer1 and STIM1 [PDF]

Acta Physiologica, 2011
AbstractInflux of Ca2+ is a central component of the receptor‐evoked Ca2+ signal. A ubiquitous form of Ca2+ influx comes from Ca2+ channels that are activated in response to depletion of the endoplasmic reticulum Ca2+ stores and are thus named the store‐operated Ca2+‐influx channels (SOCs). One form of SOC is the transient receptor potential canonical (
J P, Yuan, K P, Lee, J H, Hong, S, Muallem   +3 more
openaire   +2 more sources

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

Brain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong, Letai Li, Yanlin Li, Yutong Chen, Jiajie Leng, Tingting Chen   +5 more
wiley   +1 more source