Results 61 to 70 of about 11,568 (219)

Post-Translational Modification and Natural Mutation of TRPC Channels

Cells, 2020
Transient Receptor Potential Canonical (TRPC) channels are homologues of Drosophila TRP channel first cloned in mammalian cells. TRPC family consists of seven members which are nonselective cation channels with a high Ca2+ permeability and are activated ...
Xianji Liu, Xiaoqiang Yao, Suk Ying Tsang   +2 more
doaj   +1 more source

Critical role of canonical transient receptor potential channel 7 in initiation of seizures [PDF]

, 2014
Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States.
Abramowitz, J., Birnbaumer, Lutz, Phelan, K. D., Shwe, U. T., Zheng, F.   +4 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. [PDF]

PLoS ONE, 2017
Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to ...
Samantha Gomart, Caroline Gaudreau-Ménard, Pascale Jespers, Omer Gurkan Dilek, Emeline Hupkens, Aliénor Hanthazi, Robert Naeije, Christian Melot, Nathalie Labranche, Laurence Dewachter, Kathleen Mc Entee   +10 more
doaj   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Transient receptor potential channel 1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating protein kinase Cα signaling [PDF]

, 2015
Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca2+ homeostasis necessary for cellular functions. However, whether TRPC1 is involved in infectious disease remains unknown.
Birnbaumer, Lutz, Huang, Canhua, Li, Xuefeng, Privratsky, Breanna, Singh, Brij B., Sun, Yuyang, Tan, Shirui, Wang, Wenxue, Wei, Yu-Quan, Wu, Min, Ye, Yan, Zhou, Xikun, Zhou, Zongguang   +12 more
core   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Endocardial TRPC-6 Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk

JACC: Basic to Translational Science, 2017
Mechanoelectrical feedback may increase arrhythmia susceptibility, but the molecular mechanisms are incompletely understood. This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective ...
Vesna Nikolova-Krstevski, PhD, Soeren Wagner, MD, Ze Yan Yu, MD, Charles D. Cox, PhD, Jasmina Cvetkovska, BSc, Adam P. Hill, PhD, Inken G. Huttner, MD, Victoria Benson, PhD, Andreas A. Werdich, PhD, Calum MacRae, MD, PhD, Michael P. Feneley, MD, PhD, Oliver Friedrich, PhD, Boris Martinac, PhD, Diane Fatkin, MD   +13 more
doaj   +1 more source

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg [PDF]

, 2011
Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis ...
CARNEIRO, F.S., GIACHINI, F.R., HANNAN, J., LIMA, V.V., TOSTES, R.C., WEBB, R.C.   +5 more
core   +3 more sources

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source