Results 81 to 90 of about 11,568 (219)
BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. [PDF]
PLoS ONE, 2014 Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process of pulmonary arterial hypertension (PAH). BMP4 plays an important role during the process of pulmonary arterial remodeling and mutant of the principle ...
Yi Zhang +9 more
doaj +1 more source
A key role of TRPC channels in the regulation of electromechanical activity of the developing heart [PDF]
, 2017 Aims It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart.
Raddatz, Eric +2 more
core
A Verified Information-Flow Architecture [PDF]
, 2016 SAFE is a clean-slate design for a highly secure computer system, with pervasive mechanisms for tracking and limiting information flows. At the lowest level, the SAFE hardware supports fine-grained programmable tags, with efficient and flexible ...
Collins, Nathan +8 more
core +5 more sources
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2704-2721, April 2026.ABSTRACT Soybean is a critical source of protein and vegetable oil worldwide. Expanding its cultivation into salinity lands represents a promising strategy for increasing production; however, soil salinity severely limits soybean growth by disrupting physiological and metabolic homeostasis.
Wanying Zhang +13 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca2+, concentration ([Ca2+]i) and physiological significance of Na+ influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese ...
Takahiro Horinouchi +7 more
doaj +1 more source
Sociability is decreased following deletion of the _trpc4_ gene [PDF]
, 2011 Shyness and social anxiety are predominant features of some psychiatric disorders including autism, schizophrenia, anxiety and depression. Understanding the cellular and molecular determinants of sociability may reveal therapeutic approaches to treat ...
Andrew L. Varnell +4 more
core +2 more sources
The Journal of Physiology, Volume 604, Issue 7, Page 3135-3158, 1 April 2026.Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes +4 more
wiley +1 more source
TRPC3 Channels in Cardiac Fibrosis
Frontiers in Cardiovascular Medicine, 2017 Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF).
Takuro Numaga-Tomita +12 more
doaj +1 more source
Rat hypocretin/orexin neurons are maintained in a depolarized state by TRPC channels. [PDF]
PLoS ONE, 2010 In a previous study we proposed that the depolarized state of the wake-promoting hypocretin/orexin (hcrt/orx) neurons was independent of synaptic inputs as it persisted in tetrodotoxin and low calcium/high magnesium solutions.
Vesna Cvetkovic-Lopes +7 more
doaj +1 more source
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels [PDF]
, 2017 The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters but understanding of these channels ...
Appleby, HL +20 more
core +2 more sources