Results 101 to 110 of about 11,568 (219)

Calcium-Dependent and Synapsin-Dependent Pathways for the Presynaptic Actions of BDNF [PDF]

, 2017
We used cultured hippocampal neurons to determine the signaling pathways mediating brain-derived neurotrophic factor (BDNF) regulation of spontaneous glutamate and GABA release. BDNF treatment elevated calcium concentration in presynaptic terminals; this
George J. Augustine, Qing Cheng, Sang-Ho Song   +2 more
core   +1 more source

Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine [PDF]

, 2018
BACKGROUND: Metabolic syndrome (MetS) and aging are prevalent risk factors for coronary artery disease (CAD) and contribute to the etiology of CAD, including dysregulation of Ca2+ handling mechanisms in coronary smooth muscle (CSM).
Badin, Jill K., Bruning, Rebecca S., Sturek, Michael   +2 more
core   +1 more source

Mating‐Type Loci Modulate Pathogenicity and Non‐Sexual Development Through Autocrine Pheromone Signalling in the Asexual Fungus Fusarium oxysporum

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
MAT loci function as bistable switches in the asexual plant‐pathogenic fungus Fusarium oxysporum, controlling population behaviour through autocrine pheromone signalling. MAT1‐1 promotes hyphal fusion and virulence while repressing germination. MAT1‐2 has opposite effects, upregulating Bar1 protease that cleaves α‐pheromone.
Stefania Vitale, Antonia Barberio, Riccardo Cantelli, Marta Ranesi, Filippo De Curtis, Antonio Di Pietro, David Turrà   +6 more
wiley   +1 more source

Sildenafil Inhibits Human Pulmonary Artery Smooth Muscle Cell Proliferation by Decreasing Capacitative Ca2+ Entry

Journal of Pharmacological Sciences, 2008
Ca2+ is a pivotal signal in human pulmonary artery smooth muscle cells (PASMCs) proliferation. Capacitative Ca2+ entry (CCE) via the store-operated channel (SOC), which encoded by the transient receptor potential (TRP) gene, is an important mechanism for
Cong Wang, Jun Wang, Lan Zhao, Yuexiu Wang, Jie Liu, Luping Shi, Meng Xu, Chen Wang   +7 more
doaj   +1 more source

Expression of TRPC6 channels in human epithelial breast cancer cells [PDF]

, 2008
Background TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear.
Arnaud Guilbert, Isabelle Dhennin-Duthille, Yassine EL Hiani, Nathalie Haren, Hafida Khorsi, Henri Sevestre, Ahmed Ahidouch, Halima Ouadid-Ahidouch, WF Wonderlin, H Ouadid-Ahidouch, H Ouadid-Ahidouch, M Potier, S Roger, S Roger, SP Fraser, IN Sergeev, JS Strobl, IN Sergeev, L Guo, L Zhuang, M Bodding, T Fixemer, M Bodding, N Prevarskaya, U Wissenbach, JB Peng, L Zhang, U Wissenbach, A Dietrich, J Soboloff, M Trebak, R Inoue, Y Yu, LC Ng, A Dietrich, AJ Hill, K Kuwahara, R Guinamard, S Thebault, Y El Hiani, SP Ethier, AB Parekh, A Dietrich, S Thebault, BK Stringer, F Mello de Queiroz, EL Ding, V Lehen'kyi, SM Vazquez   +48 more
core   +2 more sources

TRPC3 and TRPC6 as molecular mediators of resistant hypertension and cardiac fibrosis: a new therapeutic frontier

Arterial Hypertension
Resistant hypertension remains a significant global health concern and is a major contributor to cardiovascular complications such as vascular dysfunction and cardiac fibrosis. Emerging evidence suggests that transient receptor potential canonical (TRPC)
Shobana Kumar, Kayatri Govindaraju, Sharifah Zamiah Syed Abdul Kadir, Abu Bakar Abdul Majeed, Amira Hajirah Abd Jamil, Nusaibah Abdul Rahim   +5 more
doaj   +1 more source

Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903. [PDF]

J Biol Chem, 2022
Baradaran-Heravi A, Bauer CC, Pickles IB, Hosseini-Farahabadi S, Balgi AD, Choi K, Linley DM, Beech DJ, Roberge M, Bon RS.   +9 more
europepmc   +1 more source

Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death.
Ayako Makino, Haiyang Tang, Jason X.-J. Yuan, Jason X.-J. Yuan, Kimberly A. Smith, Ramon J. Ayon   +5 more
core   +3 more sources

TRPC channel-derived calcium fluxes differentially regulate ATP and flow-induced activation of eNOS. [PDF]

Nitric Oxide, 2021
Muzorewa TT, Buerk DG, Jaron D, Barbee KA.   +3 more
europepmc   +1 more source

(-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase [PDF]

, 2016
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing Transient Receptor Potential Canonical 4 protein (TRPC4).
Akbulut, Alevizopoulos, Alfonso, Carson, Dietrich, Engl, Fash, Kim, Li, López-Suárez, Naylor, Plant, Radtke, Rajasekaran, Ratnayake, Reinhold, Schaefer, Selvakumar, Shankavaram, Shi, Sourbier, Storch, Strübing, Xu   +23 more
core   +1 more source