Results 1 to 10 of about 6,649 (159)
TRPC Channels in Cardiac Plasticity [PDF]
Cells, 2020 The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Takuro Numaga-Tomita, Motohiro Nishida
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TRPC Channels in the SOCE Scenario [PDF]
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
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Transient Receptor Potential Canonical (TRPC) Channels: Then and Now [PDF]
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen +4 more
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TRPC Channels in Proteinuric Kidney Diseases [PDF]
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall +2 more
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Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke [PDF]
Frontiers in Cell and Developmental Biology, 2021 The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but ...
Jaepyo Jeon +12 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease [PDF]
Cells, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Débora Falcón +7 more
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Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes [PDF]
Biomolecules, 2023 An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen +6 more
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How TRPC Channels Modulate Hippocampal Function. [PDF]
Int J Mol Sci, 2020 Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions.
Gualdani R, Gailly P.
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TRPC Channels and Parkinson's Disease. [PDF]
Adv Exp Med Biol, 2017 Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca2+ signaling ...
Sukumaran P +4 more
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Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels [PDF]
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
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