Transient Receptor Potential Canonical (TRPC) Channels: Then and Now [PDF]
Cells, 2020 Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC) channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there are seven TRPC channels (TRPC1–7).
Xingjuan Chen +4 more
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Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke [PDF]
Frontiers in Cell and Developmental Biology, 2021 The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but ...
Jaepyo Jeon +12 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease [PDF]
Cells, 2020 Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli.
Débora Falcón +7 more
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Transient receptor potential canonical (TRPC) channels in diabetes and associated complications [PDF]
ChannelsTRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
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TRPC Channels in the SOCE Scenario [PDF]
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
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Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes [PDF]
Biomolecules, 2023 An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying.
Gui-Lan Chen +6 more
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TRPC Channels in Cardiac Plasticity [PDF]
Cells, 2020 The heart flexibly changes its structure in response to changing environments and oxygen/nutrition demands of the body. Increased and decreased mechanical loading induces hypertrophy and atrophy of cardiomyocytes, respectively.
Takuro Numaga-Tomita, Motohiro Nishida
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Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels [PDF]
Cells, 2020 TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of ...
Juan E. Camacho Londoño +8 more
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TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension [PDF]
Respiratory ResearchBackground- Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with ...
Anaïs Saint-Martin Willer +13 more
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Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury [PDF]
Frontiers in Neuroscience, 2021 We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver +3 more
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