Results 31 to 40 of about 802,879 (181)
TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses. [PDF]
PLoS Biology, 2019 Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the ...
Yvonne Schwarz +8 more
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Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain [PDF]
Neural Plasticity, 2020 Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain ...
Zhi-Chuan Sun +4 more
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TRPC Channels and Neuron Development, Plasticity, and Activities
, 2017 In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their ...
Yilin, Tai, Yichang, Jia
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Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update
Cells, 2021 This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley +3 more
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The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
Cells, 2014 Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
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Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine [PDF]
, 2022 Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC channels are thought to act as complex integrators of physical and chemical environmental
Bon, RS +3 more
core +1 more source
TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease [PDF]
, 2020 Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth ...
Martín Bórnez, Marta +10 more
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Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Journal of Lipid and Atherosclerosis, 2020 Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response
Motohiro Nishida +4 more
doaj +1 more source
mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
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The integrative function of TRPC channels
Frontiers in Bioscience, 2009 TRPC is a subfamily of Transient Receptor Potential channels that have the highest degree of homology to the Drosophila photoreceptors' TRP. TRPC open in response to stimulation of plasma membrane receptors that activate phospholipase C, triggering transmembrane Ca2+ influx.
Kirill, Kiselyov, Randen L, Patterson
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