Results 31 to 40 of about 6,649 (159)

Transient Receptor Potential Canonical Channels in Health and Disease: A 2020 Update

Cells, 2021
This 2020 Special Issue “TRPC channels” of Cells was dedicated to commemorating the 25th anniversary of discovery of the Transient Receptor Potential Canonical (TRPC) channel subfamily [...]
Priya R. Kirtley, Gagandeep S. Sooch, Fletcher A. White, Alexander G. Obukhov   +3 more
doaj   +1 more source

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

Cells, 2014
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
doaj   +1 more source

The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling in Aspergillus nidulans

mSphere, 2023
Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang, Renwei Gao, Yuanwei Zhang, Ling Lu   +3 more
doaj   +1 more source

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Journal of Lipid and Atherosclerosis, 2020
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response
Motohiro Nishida, Tomohiro Tanaka, Supachoke Mangmool, Kazuhiro Nishiyama, Akiyuki Nishimura   +4 more
doaj   +1 more source

Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. [PDF]

PLoS ONE, 2013
The canonical transient receptor potential (TRPC) channels are Ca(2+)-permeable cationic channels controlling the Ca(2+) influx evoked by G protein-coupled receptor activation and/or by Ca(2+) store depletion. Here we investigate the involvement of TRPCs
Hong-Ni Jiang, Bo Zeng, Yi Zhang, Nikoleta Daskoulidou, Hong Fan, Jie-Ming Qu, Shang-Zhong Xu   +6 more
doaj   +1 more source

Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway

Frontiers in Pharmacology, 2015
Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori, Kyohei eItsuki, Hideharu eHase, Seishirou eSawamura, Tatsuki eKurokawa, Yasuo eMori, Ryuji eInoue   +6 more
doaj   +1 more source

Physiological Function and Characterization of TRPCs in Neurons

Cells, 2014
Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2 ...
Yuyang Sun, Pramod Sukumaran, Bidhan C. Bandyopadhyay, Brij B. Singh   +3 more
doaj   +1 more source

TRPC channel activation by extracellular thioredoxin [PDF]

Nature, 2008
Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identification of endogenous activators and the determination of cellular and tissue functions of these channels ...
Xu, Shang-Zhong, Al-Shawaf, Eman, Bahnasi, Yahya M., Beech, David J., Ciurtin, Coziana, Emery, Paul, English, Anne, Jairaman, Amit, Jiang, Lin-Hua, Li, Jing, Majeed, Yasser, Milligan, Carol J., Naylor, Jacqueline, Porter, Karen E., Sivaprasadarao, Asipu, Sukumar, Piruthivi, Zeng, Fanning   +16 more
openaire   +3 more sources

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

Cells, 2019
The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So   +3 more
doaj   +1 more source

A diacylglycerol photoswitching protocol for studying TRPC channel functions in mammalian cells and tissue slices

STAR Protocols, 2021
Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels.
Trese Leinders-Zufall, Ursula Storch, Michael Mederos y Schnitzler, Navin K. Ojha, Kohei Koike, Thomas Gudermann, Frank Zufall   +6 more
doaj   +1 more source