Regulatory mechanisms controlling store-operated calcium entry [PDF]
Frontiers in Physiology, 2023 Calcium influx through plasma membrane ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors (IP3R) in the endoplasmic reticulum (ER)
Goutham Kodakandla +2 more
doaj +4 more sources
Store‐operated calcium entry mediates hyperalgesic responses during neuropathy [PDF]
FEBS Open Bio, 2023 Neuropathic pain (NP), resulting from nerve injury, alters neural plasticity in spinal cord and brain via the release of inflammatory mediators. The remodeling of store‐operated calcium entry (SOCE) involves the refilling of calcium in the endoplasmic ...
Wei Wang +10 more
doaj +2 more sources
Celastrol inhibits store operated calcium entry and suppresses psoriasis [PDF]
Frontiers in Pharmacology, 2023 Introduction: Psoriasis is an inflammatory autoimmune skin disease that is hard to cure and prone to relapse. Currently available global immunosuppressive agents for psoriasis may cause severe side effects, thus it is crucial to identify new therapeutic ...
Xiaoman Yuan +15 more
doaj +2 more sources
Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI
Neurobiology of Disease, 2020 Axonal degeneration plays a key role in the pathogenesis of numerous neurological disorders including spinal cord injury. After the irreversible destruction of the white matter elements during the primary (mechanical) injury, spared axons and their ...
Ben C. Orem +2 more
doaj +3 more sources
Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
Cells, 2022 Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and ...
Isaac Jardin +5 more
doaj +3 more sources
Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration [PDF]
Cell Death DiscoveryPatients with neurodegenerative diseases such as retinitis pigmentosa (RP) may engage in maladaptive coping behaviors, including alcohol misuse, which can aggravate disease progression. Neuroinflammation, a hallmark of RP, is largely driven by microglial
Théo Henrique de Lima-Vasconcellos +6 more
doaj +2 more sources
Store-Operated Calcium Entry Increases Nuclear Calcium in Adult Rat Atrial and Ventricular Cardiomyocytes [PDF]
Cells, 2023 Store-operated calcium entry (SOCE) in cardiomyocytes may be involved in cardiac remodeling, but the underlying mechanisms remain elusive. We hypothesized that SOCE may increase nuclear calcium, which alters gene expression via calcium/calmodulin ...
Julia Hermes +2 more
doaj +2 more sources
Up-Regulation of the TRPM8 Channel Attenuates TRPC1-Mediated Store-Operated Calcium Entry in Abdominal Aortic Aneurysm [PDF]
BiomoleculesAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease characterized by vascular smooth muscle cell (VSMC) dysfunction and disrupted calcium homeostasis.
Yi-Qian Wang +7 more
doaj +2 more sources
Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids [PDF]
Function, 2022 J Ashot Kozak
doaj +2 more sources
Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats [PDF]
International Journal of Molecular Sciences, 2023 Kira Derkach +2 more
exaly +2 more sources