Results 1 to 10 of about 2,808,407 (277)
Regulatory mechanisms controlling store-operated calcium entry [PDF]
Frontiers in Physiology, 2023 Calcium influx through plasma membrane ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors (IP3R) in the endoplasmic reticulum (ER)
Goutham Kodakandla +2 more
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Store‐operated calcium entry mediates hyperalgesic responses during neuropathy [PDF]
FEBS Open Bio, 2023 Neuropathic pain (NP), resulting from nerve injury, alters neural plasticity in spinal cord and brain via the release of inflammatory mediators. The remodeling of store‐operated calcium entry (SOCE) involves the refilling of calcium in the endoplasmic ...
Wei Wang +10 more
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Celastrol inhibits store operated calcium entry and suppresses psoriasis [PDF]
Frontiers in Pharmacology, 2023 Introduction: Psoriasis is an inflammatory autoimmune skin disease that is hard to cure and prone to relapse. Currently available global immunosuppressive agents for psoriasis may cause severe side effects, thus it is crucial to identify new therapeutic ...
Xiaoman Yuan +15 more
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STIM and Orai1 variants in store-operated calcium entry [PDF]
Frontiers in Pharmacology, 2016 Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM ...
JUAN ANTONIO ROSADO +3 more
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Store-operated calcium entry: Mechanisms and modulation [PDF]
Biochemical and Biophysical Research Communications, 2015 Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease.
Patrick Hogan, Anjana Rao
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Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
Cells, 2022 Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and ...
Isaac Jardin +5 more
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Methods for studying store-operated calcium entry [PDF]
Methods, 2008 Activation of surface membrane receptors coupled to phospholipase C results in the generation of cytoplasmic Ca2+ signals comprised of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. A primary mechanism for this Ca2+ entry process is attributed to store-operated Ca2+ entry, a process that is activated by ...
Jeremy Smyth, James Putney, Gary Bird
exaly +3 more sources
Frontiers in Cellular Neuroscience, 2021 It is well-established that astrocytes respond to norepinephrine with cytosolic calcium rises in various brain areas, such as hippocampus or neocortex. However, less is known about the effect of norepinephrine on olfactory bulb astrocytes. In the present
Timo Fischer +4 more
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Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration [PDF]
Cell Death DiscoveryPatients with neurodegenerative diseases such as retinitis pigmentosa (RP) may engage in maladaptive coping behaviors, including alcohol misuse, which can aggravate disease progression. Neuroinflammation, a hallmark of RP, is largely driven by microglial
Théo Henrique de Lima-Vasconcellos +6 more
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Store-Operated Calcium Entry Increases Nuclear Calcium in Adult Rat Atrial and Ventricular Cardiomyocytes [PDF]
Cells, 2023 Store-operated calcium entry (SOCE) in cardiomyocytes may be involved in cardiac remodeling, but the underlying mechanisms remain elusive. We hypothesized that SOCE may increase nuclear calcium, which alters gene expression via calcium/calmodulin ...
Julia Hermes +2 more
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