Stromal Interaction Molecule 1 Promotes the Replication of vvIBDV by Mobilizing Ca2+ in the ER [PDF]
Viruses, 2022 Infectious bursal disease virus (IBDV) is one of the main threats to the poultry industry worldwide. Very virulent IBDV (vvIBDV) is a fatal virus strain that causes heavy mortality in young chicken flocks.
Nana Yan +14 more
doaj +4 more sources
Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice [PDF]
Frontiers in Physiology, 2023 Introduction: The intracellular Ca2+ sensor stromal interaction molecule 1 (STIM1) is thought to play a critical role in enamel development, as its mutations cause Amelogenesis Imperfecta (AI).
Raed Said +10 more
doaj +4 more sources
Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle [PDF]
Biomolecules, 2021 Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park +3 more
doaj +5 more sources
Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics [PDF]
Frontiers in Physiology, 2021 Store-operated Ca2+ entry (SOCE) is an essential pathway for Ca2+ signaling, and regulates various vital cellular functions. It is triggered by the endoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1).
Yi-Ting Huang +7 more
doaj +5 more sources
Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. [PDF]
PLoS ONE, 2017 Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy.
Takayoshi Ohba +8 more
doaj +5 more sources
Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart [PDF]
Physiological Reports, 2022 Stromal interaction molecule 1 (STIM1) is a major regulator of store‐operated calcium entry in non‐excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STIM1 in the heart ...
Helen E. Collins +3 more
doaj +3 more sources
Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction [PDF]
Circulation Research, 2017 Rationale: Pathological increases in cardiac afterload result in myocyte hypertrophy with changes in myocyte electrical and mechanical phenotype. Remodeling of contractile and signaling Ca 2+ occurs in pathological hypertrophy and is central to myocyte ...
Jonathan Soboloff +2 more
exaly +5 more sources
miR-185 silencing promotes the progression of atherosclerosis via targeting stromal interaction molecule 1 [PDF]
Cell Cycle, 2019 Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play a key role in gene regulation in the formation and development of atherosclerotic plaques. Herein, the role and target gene of miR-185 in AS were explored.Cell viability, migration and invasion were examined by cell counting kit-8 (CCK-8) and transwell assay.
, Fang Ming, Yingbiao Wu
exaly +5 more sources
Swing-out opening of stromal interaction molecule 1. [PDF]
Protein Sci, 2023 AbstractStromal interaction molecule 1 (STIM1) resides in the endoplasmic reticulum (ER) membrane and senses luminal calcium (Ca2+) concentration. STIM1 activation involves a large‐scale conformational transition that exposes a STIM1 domain termed “CAD/SOAR”, ‐ which is required for activation of the calcium channel Orai. Under resting cell conditions,
Horvath F +8 more
europepmc +4 more sources
A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1) [PDF]
Journal of Biological Chemistry, 2014 Store-operated Ca(2+) entry, essential for the adaptive immunity, is initiated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1. Ca(2+) entry occurs through the plasma membrane resident Ca(2+) channel Orai1 that directly interacts with the C-terminal STIM1 domain, named SOAR/CAD.
Peter B Stathopulos +2 more
exaly +5 more sources