Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice [PDF]
Frontiers in Physiology, 2023 Introduction: The intracellular Ca2+ sensor stromal interaction molecule 1 (STIM1) is thought to play a critical role in enamel development, as its mutations cause Amelogenesis Imperfecta (AI).
Raed Said +10 more
doaj +6 more sources
Stromal Interaction Molecule 1 Promotes the Replication of vvIBDV by Mobilizing Ca2+ in the ER [PDF]
Viruses, 2022 Infectious bursal disease virus (IBDV) is one of the main threats to the poultry industry worldwide. Very virulent IBDV (vvIBDV) is a fatal virus strain that causes heavy mortality in young chicken flocks.
Nana Yan +14 more
doaj +5 more sources
Pathological Mechanism of a Constitutively Active Form of Stromal Interaction Molecule 1 in Skeletal Muscle [PDF]
Biomolecules, 2021 Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park +3 more
doaj +6 more sources
Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. [PDF]
PLoS ONE, 2017 Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy.
Takayoshi Ohba +8 more
doaj +8 more sources
Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics [PDF]
Frontiers in Physiology, 2021 Store-operated Ca2+ entry (SOCE) is an essential pathway for Ca2+ signaling, and regulates various vital cellular functions. It is triggered by the endoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1).
Yi-Ting Huang +7 more
doaj +5 more sources
Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis [PDF]
Frontiers in Physiology, 2021 Chronic obstructive pulmonary disease (COPD), primarily attributed to cigarette smoke (CS), is characterized by multiple pathophysiological changes, including oxidative stress and inflammation. Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor that
Xianying Zhu +7 more
doaj +4 more sources
CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity [PDF]
Molecular Metabolism, 2022 Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic ...
Jian Qiu +6 more
doaj +2 more sources
Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart [PDF]
Physiological Reports, 2022 Stromal interaction molecule 1 (STIM1) is a major regulator of store‐operated calcium entry in non‐excitable cells. Recent studies have suggested that STIM1 plays a role in pathological hypertrophy; however, the physiological role of STIM1 in the heart ...
Helen E. Collins +3 more
doaj +2 more sources
Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloblastic Leukemia-M5 Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities [PDF]
Turkish Journal of Hematology, 2023 Objective: This study aimed to investigate the role of the stromal interaction molecule 1 (STIM1) gene in the survival of the acute myeloblastic leukemia (AML)-M5 cell line (THP-1). Materials and Methods: The STIM1 effect was assessed via dicersubstrate
Eman Salem Algariri +5 more
doaj +2 more sources
Stromal interaction molecule 1/microtubule‐associated protein 1A/1B‐light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy [PDF]
MedCommMetastasis is the leading cause of death in hepatocellular carcinoma (HCC) patients, and autophagy plays a crucial role in this process by orchestrating epithelial–mesenchymal transition (EMT).
Jingchun Wang +10 more
doaj +2 more sources