Results 1 to 10 of about 6,637 (117)
Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases [PDF]
ChannelsStore-operated calcium entry (SOCE) mediated by STIM and Orai proteins is a fundamental Ca2+ influx mechanism that critically regulates intracellular calcium homeostasis and participates in cardiovascular pathophysiology.
Xin Liao +3 more
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STIM/Orai-Mediated Store-Operated Ca2+ Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities [PDF]
CellsStore-operated calcium entry (SOCE), mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule (STIM) proteins and the plasma membrane (PM) Orai channels, is essential for calcium signaling and a wide range of physiological ...
Yang Yi +4 more
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Context-dependent dysregulation of store-operated calcium channels in head and neck squamous cell carcinoma. [PDF]
PLoS ONEStore-operated calcium entry (SOCE), mediated by ORAI1-3 calcium channels and stromal interaction molecules STIM1 and STIM2, is increasingly recognized as a regulator of cancer progression.
Heba Ghozlan +4 more
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Effect of SKF96365 on Myocardial Fibrosis in Type-II Diabetic Rats
Frontiers in Bioscience-Landmark, 2023 Background: Diabetes mellitus type 2 is a risk factor for developing heart failure and myocardial fibrosis, but there is no specific therapy for diabetic heart disease.
Huan-zhi Liu, Wei Wu
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Frontiers in Psychology, 2022 BackgroundDo sexual minority persons who have undergone unsuccessful sexual orientation change efforts (SOCE) suffer subsequent psychological or social harm from the attempt?
D. Paul Sullins, D. Paul Sullins
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Cells, 2023 Store-operated calcium entry (SOCE) in cardiomyocytes may be involved in cardiac remodeling, but the underlying mechanisms remain elusive. We hypothesized that SOCE may increase nuclear calcium, which alters gene expression via calcium/calmodulin ...
Julia Hermes +2 more
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The Role of TRPC1 in Modulating Cancer Progression
Cells, 2020 Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer.
Osama M Elzamzamy +2 more
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Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells. [PDF]
PLoS ONE, 2012 Neuroendocrine differentiation (NED) is a hallmark of advanced androgen-independent prostate cancer, for which no successful therapy exists. NED tumour cells escape apoptotic cell death by alterations of Ca(2+) homeostasis where the store-operated Ca(2+)
Karine Vanoverberghe +7 more
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Store-Operated Calcium Entry in Skeletal Muscle: What Makes It Different?
Cells, 2021 Current knowledge on store-operated Ca2+ entry (SOCE) regarding its localization, kinetics, and regulation is mostly derived from studies performed in non-excitable cells.
Elena Lilliu +3 more
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Saudi Pharmaceutical Journal, 2023 Store-operated calcium entry (SOCE) is an important pathway for calcium signaling that regulates calcium influx across the plasma membrane upon the depletion of calcium stores in the endoplasmic reticulum.
Abdullah S. Alhamed +11 more
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