Results 1 to 10 of about 6,490 (134)

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening. [PDF]

Protein Sci
Abstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Fröhlich M, Radišković T, Hopl V, Prantl M, Najjar H, Harant S, Thallinger D, Anwar MS, Horvath F, Söllner J, Nazarenko Y, Sallinger M, Müller N, Tiffner A, Weiß S, Grabmayr H, Krobath H, Derler I.   +17 more
europepmc   +2 more sources

Orai1-mediated Ca2+ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis [PDF]

Experimental and Molecular Medicine
Cold-induced thermogenesis in brown adipose tissue is essential for maintaining energy homeostasis, yet the Ca2+-dependent mechanisms underlying this process remain incompletely understood.
Suji Kim, Phan Anh Nguyen, Kyu-Sang Park, Seung-Kuy Cha, Jun Namkung   +4 more
doaj   +2 more sources

Exacerbated Skeletal Muscle Phenotype in Mice with ‘Homotypic’ Expression of the Tubular Aggregate Myopathy ORAI1 G100S Mutation [PDF]

Biomedicines
Background: Tubular aggregate myopathy (TAM) is an autosomal dominant myopathy that results from gain-of-function mutations in the STIM1 and ORAI1 genes, which encode the two key proteins that coordinate store-operated Ca2+ entry in skeletal muscle and ...
Nan Zhao, Miao He, Robert T. Dirksen
doaj   +2 more sources

Plasma biomarker ORAI1 as a dual prognostic value for survival and postoperative quality of life in glioma patients [PDF]

Scientific Reports
Gliomas represent one of the most common and highly malignant primary brain tumors, with overall prognosis remaining unsatisfactory to date. Although certain molecular biomarkers have been identified to stratify patients based on survival outcomes, non ...
Zeyu Zhang, Yu Xiang, Ying Zhang, Hui Li, Yun Cheng   +4 more
doaj   +2 more sources

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation

Life Science Alliance, 2023
This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE ...
Tao Yu, Xi Li, Qianqian Luo, Huajing Liu, Jing Jin, Shengjie Li, Jun He   +6 more
doaj   +1 more source

Orai1-mediated store-operated Ca2+ entry promotes cervical cancer progression through IL-6 signaling

Frontiers in Molecular Biosciences, 2022
Cervical cancer is a major cause of cancer-associated mortality among women in developing countries. Orai1-mediated store-operated Ca2+ entry (SOCE) is the primary mechanism underlying most of the non-excitable calcium influx into cells.
Yiyun Pan, Yiyun Pan, Jing Huang, Kang Liu, Chuanhua Xie, Hailong Chen, Zhong Guo, Shoujun Guo, Yijian Chen, Yijian Chen   +9 more
doaj   +1 more source

SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel

Physiological Reports, 2022
Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway ...
Tongde Wu, Alexandra S. Goriounova, Erin N. Worthington, Joe A. Wrennall, Arunava Ghosh, Saira Ahmad, M. Flori Sassano, Robert Tarran   +7 more
doaj   +1 more source

The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1.

PLoS ONE, 2023
The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice.
Lisa J Robinson, Jonathan Soboloff, Irina L Tourkova, Quitterie C Larrouture, Kelechi M Onwuka, Dionysios J Papachristou, Scott Gross, Robert Hooper, Elsie Samakai, Paul F Worley, Peng Liu, Jan Tuckermann, Michelle R Witt, Harry C Blair   +13 more
doaj   +1 more source

Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. [PDF]

PLoS Biology, 2011
Store-operated Ca²+ entry (SOCE) has been associated with two types of channels: CRAC channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and STIM1.
Kwong Tai Cheng, Xibao Liu, Hwei Ling Ong, William Swaim, Indu S Ambudkar   +4 more
doaj   +1 more source

Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

BMC Musculoskeletal Disorders, 2022
Background The purpose of this study was to determine the role of Orai1 in the regulation of the proliferation and cell cycle of osteoblasts. Methods The expression of Orai1 was inhibited by Orai1 small interfering RNA (siRNA) in MC3T3-E1 cells ...
Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao   +3 more
doaj   +1 more source