Results 1 to 10 of about 6,378 (182)
Immunodeficiency due to mutations in ORAI1 and STIM1 [PDF]
Clinical Immunology, 2010 Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of ...
Stefan, Feske +2 more
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Bone Reports, 2018 Osteoblast lineage cells, a group of cells including mesenchymal progenitors, osteoblasts, and osteocytes, are tightly controlled for differentiation, proliferation and stage-specific functions in processes of skeletal development, growth and maintenance.
Hyewon Choi +6 more
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Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.
PLoS ONE, 2015 Store-operated CRAC channels regulate a wide range of cellular functions including gene expression, chemotaxis, and proliferation. CRAC channels consist of two components: the Orai proteins (Orai1-3), which form the ion-selective pore, and STIM proteins (
Leidamarie Tirado-Lee +2 more
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Orai1 calcium channels in the vasculature [PDF]
Pflügers Archiv - European Journal of Physiology, 2012 Orai1 was discovered in T cells as a calcium-selective channel that is activated by store depletion. Recent studies suggest that it is expressed and functionally important also in blood vessels, not only because haematopoietic cells can incorporate in the vascular wall but also because Orai1 is expressed and functional in vascular smooth muscle cells ...
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BMP9 promotes bone differentiation of bone marrow mesenchymal stem cells via Orai1 pathway [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the role of calcium release activated calcium channel protein 1 (Orai1) in bone marrow mesenchymal stem cells (BMSCs) osteogenesis induced by bone morphogenetic protein 9 (BMP9).
ZHOU Jia-wang, LU Guo-hai, LI Xiao-lin
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Orai1, STIM1, and their associating partners
The Journal of Physiology, 2012 Abstract Store‐operated Ca2+ (SOC) entry is one of the major mechanisms to raise intracellular Ca2+ concentration in non‐excitable cells. Ca2+‐release‐activated Ca2+ (CRAC) channels are a subtype of SOC channels that are extensively characterized in immune cells.
Sonal, Srikanth, Yousang, Gwack
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STIM proteins, Orai1, and gene expression [PDF]
Channels, 2013 Cytoplasmic Ca(2+) is an universal intracellular messenger that activates cellular responses over a broad temporal range, from neurotransmitter release to cell growth and proliferation. Inherent to the use of the multifarious Ca(2+) signal is the question of specificity: how can some Ca(2+)-dependent responses be activated in a cell and not others?
Pulak, Kar, Anant, Parekh
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Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. [PDF]
PLoS ONE, 2011 The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells. However, the molecular mechanism of SOCE in neurons remains unclear.
Joanna Gruszczynska-Biegala +3 more
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Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation [PDF]
Journal of Biological Chemistry, 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown.
Martin, Muik +14 more
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Stem Cell Research, 2014 Store-operated Ca2+ entry (SOCE) is an important Ca2+ influx pathway in non-excitable cells. STIM1, an ER Ca2+ sensor, and Orai1, a plasma membrane Ca2+ selective channel, are the two essential components of the Ca2+ release activated channel (CRAC ...
Baixia Hao +5 more
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