Results 41 to 50 of about 8,832 (217)

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.

PLoS ONE, 2015
Store-operated CRAC channels regulate a wide range of cellular functions including gene expression, chemotaxis, and proliferation. CRAC channels consist of two components: the Orai proteins (Orai1-3), which form the ion-selective pore, and STIM proteins (
Leidamarie Tirado-Lee, Megumi Yamashita, Murali Prakriya   +2 more
doaj   +1 more source

Calcium Channel Protein ORAI1 Mediates TGF-β Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells

Frontiers in Oncology, 2021
Accumulating evidence suggested that calcium release-activated calcium modulator 1(ORAI1), a key calcium channel pore-forming protein-mediated store-operated Ca2+ entry (SOCE), is associated with human cancer. However, its role in colorectal cancer (CRC)
Qingjie Kang, Xudong Peng, Xiangshu Li, Denghua Hu, Guangxu Wen, Zhengqiang Wei, Baohong Yuan   +6 more
doaj   +1 more source

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH [PDF]

, 2017
Ca release activated Ca (CRAC) channels composed of two cellular proteins, Ca-sensing stromal interaction molecule 1 (STIM1) and pore-forming Orai1, are the main mediators of the Ca entry pathway activated in response to depletion of intracellular Ca ...
Barritt, G., F. H. Zhou, G. J. Barritt, Zhou, FH, Rychkov, GY, Ma, L, Barritt, Gregory John, Whiley, David M, Gavriliouk, D, Zhou, F. H., Ma, L., S. Grigoryev, Rychkov, G. Y., Gavriliouk, D., Rychkov, G., Barritt, GJ, Barritt, G. J., N. R. Scrimgeour, G. Y. Rychkov, Gavriliouk, Dan, Ma, Lijia, Rychkov, Grigori Y, Scrimgeour, N., Zhou, David F H, Grigoryev, S, Grigoryev, Sergei A, Grigoryev, S., Zhou, F., Scrimgeour, Nathan, D. Gavriliouk, L. Ma, Scrimgeour, NR, Scrimgeour, N. R.   +32 more
core   +1 more source

A novel STIM1-Orai1 gating interface essential for CRAC channel activation. [PDF]

, 2019
Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel.
Muik, Martin, Groschner, Klaus, Frischauf, Irene, Bhardwaj, Rajesh, Romanin, Christoph, Hediger, Matthias A., Butorac, Carmen, Schober, Romana, Derler, Isabella, Krizova, Adéla, Lindinger, Sonja, Lunz, Victoria, Stadlbauer, Michael   +12 more
core   +2 more sources

Orai1 at Membrane

, 2022
Data for Orai1 signal restricted to the plasma ...
Declan Manning (13171413)
core   +1 more source

Orai1 calcium channels in the vasculature [PDF]

Pflügers Archiv - European Journal of Physiology, 2012
Orai1 was discovered in T cells as a calcium-selective channel that is activated by store depletion. Recent studies suggest that it is expressed and functionally important also in blood vessels, not only because haematopoietic cells can incorporate in the vascular wall but also because Orai1 is expressed and functional in vascular smooth muscle cells ...
openaire   +2 more sources

Orai1, STIM1, and their associating partners

The Journal of Physiology, 2012
Abstract  Store‐operated Ca2+ (SOC) entry is one of the major mechanisms to raise intracellular Ca2+ concentration in non‐excitable cells. Ca2+‐release‐activated Ca2+ (CRAC) channels are a subtype of SOC channels that are extensively characterized in immune cells.
Sonal, Srikanth, Yousang, Gwack
openaire   +3 more sources

BMP9 promotes bone differentiation of bone marrow mesenchymal stem cells via Orai1 pathway [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the role of calcium release activated calcium channel protein 1 (Orai1) in bone marrow mesenchymal stem cells (BMSCs) osteogenesis induced by bone morphogenetic protein 9 (BMP9).
ZHOU Jia-wang, LU Guo-hai, LI Xiao-lin
doaj  

Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. [PDF]

PLoS ONE, 2011
The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells. However, the molecular mechanism of SOCE in neurons remains unclear.
Joanna Gruszczynska-Biegala, Pawel Pomorski, Marta B Wisniewska, Jacek Kuznicki   +3 more
doaj   +1 more source

Role of STIM1 in survival and neural differentiation of mouse embryonic stem cells independent of Orai1-mediated Ca2+ entry

Stem Cell Research, 2014
Store-operated Ca2+ entry (SOCE) is an important Ca2+ influx pathway in non-excitable cells. STIM1, an ER Ca2+ sensor, and Orai1, a plasma membrane Ca2+ selective channel, are the two essential components of the Ca2+ release activated channel (CRAC ...
Baixia Hao, Yingying Lu, Qian Wang, Wenjing Guo, King-Ho Cheung, Jianbo Yue   +5 more
doaj   +1 more source