Results 41 to 50 of about 6,378 (182)
Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
Cells, 2021 Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
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Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology
Marine Drugs, 2023 Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation.
Sung Eun Kim +8 more
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FASEB BioAdvances, 2020 ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes.
Anri Aki +10 more
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Orai1 channels in skeletal myotubes [PDF]
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009 ISSN 1990-7478, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009, Vol. 3, No. 3, p. 299. © Pleiades Publishing, Ltd., 2009.Original Russian Text © P.V. Avdonin, I.B. Sukhanova, K.V. Surkov, O. Petermann, U.T. Rueggc, 2009, published in Biologicheskie Membrany, 2009, Vol. 26, No. 4, p. 305.
P. V. Avdonin +4 more
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Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1
Frontiers in Pharmacology, 2021 The pathophysiology of cardiac hypertrophy is complex and multifactorial. Both the store-operated Ca2+ entry (SOCE) and excessive autophagy are the major causative factors for pathological cardiac hypertrophy.
Chang-Bo Zheng +12 more
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PLoS ONE, 2022 Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs.
Hiroko Nemoto +10 more
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Cholesterol Regulates Orai1 Function [PDF]
Biophysical Journal, 2014 STIM1 and Orai proteins represent the essential molecular components of Ca2+ release-activated Ca2+ (CRAC) channels. Following ER-store depletion, CRAC current activation occurs due to the physical interaction between the STIM1 C-terminus and Orai1 N- and C-termini.
Derler, Isabella +7 more
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CFTR Modulates Orai1 Dynamics [PDF]
Biophysical Journal, 2011 Calcium signaling regulates many cellular processes and is upregulated in cystic fibrosis (CF) epithelial cells. Agonists stimulate Ca2+ release from ER stores and trigger the formation of a complex between the plasma membrane (PM) Ca2+ channel Orai1 and stromal interaction molecule 1 (STIM1), a primarily endoplasmic reticulum (ER) resident protein ...
AbuArish, Asmahan +4 more
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Regulation of neuropathic pain by microglial Orai1 channels
Science Advances, 2022 Microglia are important mediators of neuroinflammation, which underlies neuropathic pain. However, the molecular checkpoints controlling microglial reactivity are not well-understood. Here, we investigated the role of Orai1 channels for microglia-mediated neuroinflammation following nerve injury and find that deletion of Orai1 in ...
Shogo Tsujikawa +11 more
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Journal of Pharmacological Sciences, 2018 TGF-β1-induced excessive deposition of ECM and EMT process of tubular epithelial cells play critical roles in the development and progression of fibrosis in diabetic nephropathy (DN).
Jifang Ma +5 more
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