Results 51 to 60 of about 6,378 (182)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

TRPC Channels in the SOCE Scenario

Cells, 2020
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez, Isaac Jardin, Jose Sanchez-Collado, Ginés M. Salido, Tarik Smani, Juan A. Rosado   +5 more
doaj   +1 more source

Amplification of CRAC current by STIM1 and CRACM1 (Orai1) [PDF]

Nature Cell Biology, 2006
Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for ...
Christine, Peinelt, Monika, Vig, Dana L, Koomoa, Andreas, Beck, Monica J S, Nadler, Murielle, Koblan-Huberson, Annette, Lis, Andrea, Fleig, Reinhold, Penner, Jean-Pierre, Kinet   +9 more
openaire   +2 more sources

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

Cell Reports, 2018
Summary: Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions.
Krishna Prasad Subedi, Hwei Ling Ong, Ga-Yeon Son, Xibao Liu, Indu Suresh Ambudkar   +4 more
doaj   +1 more source

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle

Cells, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel, Jian Shi, William A. Large, Anthony P. Albert   +3 more
doaj   +1 more source

Properties of Orai1 mediated store‐operated current depend on the expression levels of STIM1 and Orai1 proteins

The Journal of Physiology, 2009
Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered essential components of the Ca2+ release activated Ca2+ (CRAC) channel. Orai1 polypeptides form the pore of the CRAC channel, while STIM1 plays the role of the endoplasmic reticulum Ca2+ sensor required for activation of CRAC current (ICRAC) by store ...
Ma, LinLin, Barritt, Gregory John, Litjens, T, Rychkov, Grigori Y, Scrimgeour, Nathan   +4 more
openaire   +6 more sources

TRPC channels function independently of STIM1 and Orai1 [PDF]

The Journal of Physiology, 2009
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca2+‐release activated Ca2+ (CRAC) channels, channels underlying store‐operated Ca2+ entry (SOCE). In addition, these proteins have been suggested to function in signalling and constructing other channels with biophysical properties distinct ...
Wayne I, DeHaven, Bertina F, Jones, John G, Petranka, Jeremy T, Smyth, Takuro, Tomita, Gary S, Bird, James W, Putney   +6 more
openaire   +2 more sources

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source

Enhanced Store-Operated Ca2+ Signal of Small Intestinal Smooth Muscle Cells Accelerates Small Bowel Transit Speed in Type 1 Diabetic Mouse

Frontiers in Physiology, 2021
Aims: The underlying mechanism of diabetic enteropathy, a common complication of type 1 diabetes, remains unclear. Store-operated Ca2+ entry (SOCE) is a ubiquitous type of Ca2+ influx involved in various cellular functions.
Fang Dai, Jizheng Guo, Yang Wang, Tian Jiang, Hongbo Chen, Ying Hu, Juan Du, Xianming Xia, Qiu Zhang, Bing Shen   +9 more
doaj   +1 more source