Results 51 to 60 of about 8,832 (217)

Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. [PDF]

, 2022
In humans, there are three paralogs of the Orai Ca2+ channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still under active investigation, several artificial and ...
Albano, Giuseppe, Kandasamy, Palanivel, Klesse, Gabriel J, Dernič, Jan, Peinelt, Christine, Frischauf, Irene, Fuster, Daniel G, Bhardwaj, Rajesh, Sallinger, Matthias, Augustynek, Bartlomiej, Gyimesi, Gergely, Hediger, Matthias A, Grabmayr, Herwig   +12 more
core   +2 more sources

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation [PDF]

Journal of Biological Chemistry, 2008
STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown.
Martin, Muik, Irene, Frischauf, Isabella, Derler, Marc, Fahrner, Judith, Bergsmann, Petra, Eder, Rainer, Schindl, Clemens, Hesch, Bernhard, Polzinger, Reinhard, Fritsch, Heike, Kahr, Josef, Madl, Hermann, Gruber, Klaus, Groschner, Christoph, Romanin   +14 more
openaire   +2 more sources

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

Cells, 2021
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Ayat S. Hammad, Khaled Machaca
doaj   +1 more source

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology

Marine Drugs, 2023
Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation.
Sung Eun Kim, Elina Da Sol Chung, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Joo Hyun Nam, Sung Joon Kim   +8 more
doaj   +1 more source

Role of Orai1 in Oral Cancer [PDF]

, 2016
Oral cancer is the�6th�most common cancer�worldwide, and more than 30,000 Americans are diagnosed with oral cancer each year. The 5-year survival rate for this group of cancers has been about 50%, despite advances in surgery, radiation, and ...
Lee, Sung Hee
core   +1 more source

Anti‐ORAI1 antibody DS‐2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T‐cell and mast cell activation

FASEB BioAdvances, 2020
ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes.
Anri Aki, Kento Tanaka, Nobumi Nagaoka, Takako Kimura, Daichi Baba, Yoshikuni Onodera, Teiji Wada, Hiroaki Maeda, Toshiyuki Nakanishi, Toshinori Agatsuma, Tomoaki Komai   +10 more
doaj   +1 more source

Orai1 channels in skeletal myotubes [PDF]

Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009
ISSN 1990-7478, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009, Vol. 3, No. 3, p. 299. © Pleiades Publishing, Ltd., 2009.Original Russian Text © P.V. Avdonin, I.B. Sukhanova, K.V. Surkov, O. Petermann, U.T. Rueggc, 2009, published in Biologicheskie Membrany, 2009, Vol. 26, No. 4, p. 305.
P. V. Avdonin, I. B. Sukhanova, K. V. Surkov, O. Petermann, U. T. Ruegg   +4 more
openaire   +1 more source

Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1

Frontiers in Pharmacology, 2021
The pathophysiology of cardiac hypertrophy is complex and multifactorial. Both the store-operated Ca2+ entry (SOCE) and excessive autophagy are the major causative factors for pathological cardiac hypertrophy.
Chang-Bo Zheng, Wen-Cong Gao, Mingxu Xie, Zhichao Li, Xin Ma, Wencong Song, Dan Luo, Yongxiang Huang, Jichen Yang, Peng Zhang, Yu Huang, Weimin Yang, Xiaoqiang Yao   +12 more
doaj   +1 more source

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. [PDF]

, 2020
BACKGROUND/AIMS Store-operated Ca2+ entry (SOCE) through plasma membrane Ca2+ channel Orai1 is essential for many cellular processes. SOCE, activated by ER Ca2+ store-depletion, relies on the gating function of STIM1 Orai1-activating region SOAR of ...
Augustynek, Bartlomiej S., Kandasamy, Palanivel, Peinelt, Christine, Bhardwaj, Rajesh, Seedorf, Matthias, Hediger, Matthias A., Ercan-Herbst, Ebru   +6 more
core   +1 more source

Regulation of neuropathic pain by microglial Orai1 channels

Science Advances, 2022
Microglia are important mediators of neuroinflammation, which underlies neuropathic pain. However, the molecular checkpoints controlling microglial reactivity are not well-understood. Here, we investigated the role of Orai1 channels for microglia-mediated neuroinflammation following nerve injury and find that deletion of Orai1 in ...
Shogo Tsujikawa, Kaitlyn E. DeMeulenaere, Maria V. Centeno, Shahrzad Ghazisaeidi, Megan E. Martin, Martinna R. Tapies, Mohammad M. Maneshi, Megumi Yamashita, Kenneth A. Stauderman, Apkar V. Apkarian, Michael W. Salter, Murali Prakriya   +11 more
openaire   +2 more sources