Results 31 to 40 of about 6,378 (182)
Cells, 2020 Pathological cardiac remodeling correlates with chronic neurohumoral stimulation and abnormal Ca2+ signaling in cardiomyocytes. Store-operated calcium entry (SOCE) has been described in adult and neonatal murine cardiomyocytes, and Orai1 proteins act as ...
Sebastian Segin +7 more
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Oncogenesis, 2022 As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intracellular calcium homeostasis implicated in the occurrence of multiple types of diseases.
Chunming Gu +9 more
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Cholesterol modulates Orai1 channel function [PDF]
Science Signaling, 2016 Cholesterol suppresses the activity of a channel needed to refill intracellular calcium stores.
Isabella, Derler +14 more
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The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis
Scientific Reports, 2021 Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE).
Rawad Hodeify +9 more
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Cell Calcium, 2019 A primary calcium (Ca2+) entry pathway into non-excitable cells is through the store-operated Ca2+ release activated Ca2+ (CRAC) channel. Ca2+ entry into cells is responsible for the initiation of diverse signalling cascades that affect essential cellular processes like gene regulation, cell growth and death, secretion and gene transcription.
Victoria Lunz +2 more
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STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy [PDF]
The Journal of Physiology, 2008 Ca2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels initiates key functions such as gene expression and exocytosis of inflammatory mediators. Activation of CRAC channels by store depletion involves the redistribution of the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1), to peripheral sites where it co‐clusters with ...
Laura, Navarro-Borelly +5 more
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Sequential Steps of CRAC Channel Activation
Cell Reports, 2017 Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood.
Raz Palty, Zhu Fu, Ehud Y. Isacoff
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The STIM1–ORAI1 microdomain [PDF]
Cell Calcium, 2015 The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2 ...
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Optical investigations reveal the effects of 2-aminoethyldiphenyl borate on STIM1 puncta formation [PDF]
Journal of Innovative Optical Health Sciences, 2018 2-Aminoethyldiphenyl borate (2-APB) is the most commonly used pharmacological agent in the study of calcium release-activated channels (CRACs); however, its inhibitory mechanism to CRACs remains unclear.
Tao Yu +4 more
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Frontiers in Oncology, 2021 Accumulating evidence suggested that calcium release-activated calcium modulator 1(ORAI1), a key calcium channel pore-forming protein-mediated store-operated Ca2+ entry (SOCE), is associated with human cancer. However, its role in colorectal cancer (CRC)
Qingjie Kang +6 more
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