Results 31 to 40 of about 8,832 (217)
The STIM1–ORAI1 microdomain [PDF]
Cell Calcium, 2015 The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2 ...
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, 2022 Store operated calcium (Ca2+) entry is an important homeostatic mechanism in cells, whereby the release of Ca2+ from intracellular endoplasmic reticulum stores triggers the activation of a Ca2+ influx pathway.
Yoast, Ryan E +16 more
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STIM1–Orai1 interactions and Orai1 conformational changes revealed by live‐cell FRET microscopy [PDF]
The Journal of Physiology, 2008 Ca2+ entry through store‐operated Ca2+ release‐activated Ca2+ (CRAC) channels initiates key functions such as gene expression and exocytosis of inflammatory mediators. Activation of CRAC channels by store depletion involves the redistribution of the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1), to peripheral sites where it co‐clusters with ...
Laura, Navarro-Borelly +5 more
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Sequential Steps of CRAC Channel Activation
Cell Reports, 2017 Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood.
Raz Palty, Zhu Fu, Ehud Y. Isacoff
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Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry. [PDF]
, 2016 N-glycosylation of cell surface proteins affects protein function, stability, and interaction with other proteins. Orai channels, which mediate store-operated Ca(2+) entry (SOCE), are composed of N-glycosylated subunits.
Kappel, Sven +6 more
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Cell Calcium, 2019 A primary calcium (Ca2+) entry pathway into non-excitable cells is through the store-operated Ca2+ release activated Ca2+ (CRAC) channel. Ca2+ entry into cells is responsible for the initiation of diverse signalling cascades that affect essential cellular processes like gene regulation, cell growth and death, secretion and gene transcription.
Victoria Lunz +2 more
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STIM proteins, Orai1, and gene expression [PDF]
Channels, 2013 Cytoplasmic Ca(2+) is an universal intracellular messenger that activates cellular responses over a broad temporal range, from neurotransmitter release to cell growth and proliferation. Inherent to the use of the multifarious Ca(2+) signal is the question of specificity: how can some Ca(2+)-dependent responses be activated in a cell and not others?
Pulak, Kar, Anant, Parekh
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Optical investigations reveal the effects of 2-aminoethyldiphenyl borate on STIM1 puncta formation [PDF]
Journal of Innovative Optical Health Sciences, 2018 2-Aminoethyldiphenyl borate (2-APB) is the most commonly used pharmacological agent in the study of calcium release-activated channels (CRACs); however, its inhibitory mechanism to CRACs remains unclear.
Tao Yu +4 more
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Bone Reports, 2018 Osteoblast lineage cells, a group of cells including mesenchymal progenitors, osteoblasts, and osteocytes, are tightly controlled for differentiation, proliferation and stage-specific functions in processes of skeletal development, growth and maintenance.
Hyewon Choi +6 more
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Immunodeficiency due to mutations in ORAI1 and STIM1 [PDF]
Clinical Immunology, 2010 Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of ...
Stefan, Feske +2 more
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