Results 11 to 20 of about 6,378 (182)
The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation [PDF]
Cells, 2021 The interplay between the Ca2+-sensitive adenylyl cyclase 8 (AC8) and Orai1 channels plays an important role both in the activation of the cAMP/PKA signaling and the modulation of Orai1-dependent Ca2+ signals. AC8 interacts with a N-terminal region that is exclusive to the Orai1 long variant, Orai1α. The interaction between both proteins allows the Ca2+
JOSÉ Sánchez-Collado +2 more
exaly +4 more sources
Septins in the Middle-Makers and Breakers of Membrane Contact Sites. [PDF]
J NeurochemSeptins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
Holt TJ, Spiliotis ET.
europepmc +2 more sources
Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta
Journal of General Physiology, 2020 Upon Ca2+ store depletion, Orai1 channels cluster and open at endoplasmic reticulum–plasma membrane (ER–PM) junctions in signaling complexes called puncta. Little is known about whether and how Orai1 channel activity may vary between individual puncta. Previously, we developed and validated optical recording of Orai channel activity, using genetically ...
Andriy V Yeromin +2 more
exaly +5 more sources
Exacerbated Skeletal Muscle Phenotype in Mice with ‘Homotypic’ Expression of the Tubular Aggregate Myopathy ORAI1 G100S Mutation [PDF]
BiomedicinesBackground: Tubular aggregate myopathy (TAM) is an autosomal dominant myopathy that results from gain-of-function mutations in the STIM1 and ORAI1 genes, which encode the two key proteins that coordinate store-operated Ca2+ entry in skeletal muscle and ...
Nan Zhao, Miao He, Robert T. Dirksen
doaj +2 more sources
Plasma biomarker ORAI1 as a dual prognostic value for survival and postoperative quality of life in glioma patients [PDF]
Scientific ReportsGliomas represent one of the most common and highly malignant primary brain tumors, with overall prognosis remaining unsatisfactory to date. Although certain molecular biomarkers have been identified to stratify patients based on survival outcomes, non ...
Zeyu Zhang +4 more
doaj +2 more sources
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
Life Science Alliance, 2023 This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE ...
Tao Yu +6 more
doaj +1 more source
Calcium, Orai1, and Epidermal Proliferation [PDF]
Journal of Investigative Dermatology, 2014 Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy.
Bikle, Daniel D., Mauro, Theodora M.
openaire +4 more sources
Orai1-mediated store-operated Ca2+ entry promotes cervical cancer progression through IL-6 signaling
Frontiers in Molecular Biosciences, 2022 Cervical cancer is a major cause of cancer-associated mortality among women in developing countries. Orai1-mediated store-operated Ca2+ entry (SOCE) is the primary mechanism underlying most of the non-excitable calcium influx into cells.
Yiyun Pan +9 more
doaj +1 more source
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
Physiological Reports, 2022 Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway ...
Tongde Wu +7 more
doaj +1 more source
PLoS ONE, 2023 The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline knock-out mice.
Lisa J Robinson +13 more
doaj +1 more source