Results 11 to 20 of about 8,832 (217)
Orai1 Boosts SK3 Channel Activation [PDF]
Cancers, 2021 The interplay of SK3, a Ca2+ sensitive K+ ion channel, with Orai1, a Ca2+ ion channel, has been reported to increase cytosolic Ca2+ levels, thereby triggering proliferation of breast and colon cancer cells, although a molecular mechanism has remained ...
Adéla Tiffner +14 more
core +3 more sources
Calcium, Orai1, and Epidermal Proliferation [PDF]
Journal of Investigative Dermatology, 2014 Ca2+ influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca2+ influx after Ca2+ release from the endoplasmic reticulum, and it has
Mauro, Theodora M., Bikle, Daniel D.
core +6 more sources
Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta [PDF]
Journal of General Physiology, 2020 Upon Ca2+ store depletion, Orai1 channels cluster and open at endoplasmic reticulum-plasma membrane (ER-PM) junctions in signaling complexes called puncta.
Dynes, Joseph L +5 more
core +5 more sources
The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation [PDF]
Cells, 2021 The interplay between the Ca2+-sensitive adenylyl cyclase 8 (AC8) and Orai1 channels plays an important role both in the activation of the cAMP/PKA signaling and the modulation of Orai1-dependent Ca2+ signals.
José Sánchez-Collado +2 more
core +4 more sources
Science Signaling, 2017 Two gates and a transmembrane site are required to open the store-operated channel Orai1.
Archana Jha, Shmuel Muallem
core +3 more sources
The Journal of Physiology, 2009 Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered essential components of the Ca2+ release activated Ca2+ (CRAC) channel.
Rychkov, G. +16 more
core +7 more sources
The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis [PDF]
Scientific Reports, 2021 Regulation of Ca2+ signaling is critical for the progression of cell division, especially during meiosis to prepare the egg for fertilization. The primary Ca2+ influx pathway in oocytes is Store-Operated Ca2+ Entry (SOCE).
Rawad Hodeify +9 more
doaj +2 more sources
Expression of ORAI1 and STIM1 genes in blood of patients with pulmonary tuberculosis [PDF]
, 2021 This study aimed to detect the expression level of ORAI1 and STIM1 genes in blood of patients with bilateral pulmonary tuberculosis (TB) in comparison with the control group.
Oksana Kolesova +7 more
core +1 more source
Orai1 Concatemers Reveal a Hexameric Orai1 Channel Assembly [PDF]
Biophysical Journal, 2016 The multimeric assembly of the CRAC channel has remained a contentious issue despite strong crystallographic evidence of a hexameric structure for both Drosophila and human Orai1. Recent studies suggested concatemeric tetramers of Orai1 mediate authentic CRAC current whereas equivalent hexameric concatemers form only non-selective cation channels.
Cai, Xiangyu +6 more
openaire +1 more source
A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
eLife, 2023 Ca 2+ release-activated Ca 2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca 2+ sensor.
Megumi Yamashita +2 more
openaire +3 more sources