Results 21 to 30 of about 8,832 (217)
Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality.
PLoS ONE, 2022 The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia.
Heba Shawer, Chew W Cheng, Marc A Bailey
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The effect of lentinan on the gene expression of major ion channels in T lymphocytes isolated from mice exposed to chronic radiation [PDF]
Nuclear Technology and Radiation Protection, 2013 It is known that Kv1.3, KCa3.1, CRAC, TRPM7, and Clswell are five important ion channels in T lymphocytes. To investigate the mechanism underlying the protective effects of lentinan against T lymphocytes injury induced by chronic radiation in mice, we
Fu Qing-Jie +7 more
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Methods to Quantify the Dynamic Recycling of Plasma Membrane Channels
Bio-Protocol, 2023 Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling modality mediated by Orai Ca2+ channels at the plasma membrane (PM) and the endoplasmic reticulum (ER) Ca2+ sensors STIM1/2.
Rawad Hodeify, Khaled Machaca
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Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
, 2022 Orai1, the first identified member of the Orai protein family, is ubiquitously expressed in the animal kingdom. Orai1 was initially characterized as the channel responsible for the store-operated calcium entry (SOCE), a major mechanism that allows ...
Nieto-Felipe, Joel +15 more
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Cells, 2022 Calcium signalling in platelets through store operated Ca2+ entry (SOCE) or receptor-operated Ca2+ entry (ROCE) mechanisms is crucial for platelet activation and function. Orai1 proteins have been implicated in platelet’s SOCE. In this study we evaluated
Linlin Yang +4 more
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Cells, 2020 Pathological cardiac remodeling correlates with chronic neurohumoral stimulation and abnormal Ca2+ signaling in cardiomyocytes. Store-operated calcium entry (SOCE) has been described in adult and neonatal murine cardiomyocytes, and Orai1 proteins act as ...
Sebastian Segin +7 more
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Cholesterol modulates Orai1 channel function [PDF]
Science Signaling, 2016 Cholesterol suppresses the activity of a channel needed to refill intracellular calcium stores.
Isabella, Derler +14 more
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The sun, cholesterol and Orai1 conspire in melanoma
The EMBO Journal, 2022 How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca2+ influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma.
Woo Young Chung, Shmuel Muallem
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Oncogenesis, 2022 As an important second messenger, calcium (Ca2+) regulates a wide variety of physiological processes. Disturbance of intracellular calcium homeostasis implicated in the occurrence of multiple types of diseases.
Chunming Gu +9 more
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