Results 21 to 30 of about 6,378 (182)
Orai1 Boosts SK3 Channel Activation [PDF]
Cancers, 2021 The interplay of SK3, a Ca2+ sensitive K+ ion channel, with Orai1, a Ca2+ ion channel, has been reported to increase cytosolic Ca2+ levels, thereby triggering proliferation of breast and colon cancer cells, although a molecular mechanism has remained elusive to date.
Adéla Tiffner +14 more
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Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. [PDF]
PLoS Biology, 2011 Store-operated Ca²+ entry (SOCE) has been associated with two types of channels: CRAC channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and STIM1.
Kwong Tai Cheng +4 more
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Orai1 Concatemers Reveal a Hexameric Orai1 Channel Assembly [PDF]
Biophysical Journal, 2016 The multimeric assembly of the CRAC channel has remained a contentious issue despite strong crystallographic evidence of a hexameric structure for both Drosophila and human Orai1. Recent studies suggested concatemeric tetramers of Orai1 mediate authentic CRAC current whereas equivalent hexameric concatemers form only non-selective cation channels.
Cai, Xiangyu +6 more
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Methods to Quantify the Dynamic Recycling of Plasma Membrane Channels
Bio-Protocol, 2023 Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling modality mediated by Orai Ca2+ channels at the plasma membrane (PM) and the endoplasmic reticulum (ER) Ca2+ sensors STIM1/2.
Rawad Hodeify, Khaled Machaca
doaj +1 more source
BMC Musculoskeletal Disorders, 2022 Background The purpose of this study was to determine the role of Orai1 in the regulation of the proliferation and cell cycle of osteoblasts. Methods The expression of Orai1 was inhibited by Orai1 small interfering RNA (siRNA) in MC3T3-E1 cells ...
Yunshan Guo +3 more
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Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality.
PLoS ONE, 2022 The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia.
Heba Shawer, Chew W Cheng, Marc A Bailey
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A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
eLife, 2023 Ca 2+ release-activated Ca 2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca 2+ sensor.
Megumi Yamashita +2 more
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The effect of lentinan on the gene expression of major ion channels in T lymphocytes isolated from mice exposed to chronic radiation [PDF]
Nuclear Technology and Radiation Protection, 2013 It is known that Kv1.3, KCa3.1, CRAC, TRPM7, and Clswell are five important ion channels in T lymphocytes. To investigate the mechanism underlying the protective effects of lentinan against T lymphocytes injury induced by chronic radiation in mice, we
Fu Qing-Jie +7 more
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Cells, 2022 Calcium signalling in platelets through store operated Ca2+ entry (SOCE) or receptor-operated Ca2+ entry (ROCE) mechanisms is crucial for platelet activation and function. Orai1 proteins have been implicated in platelet’s SOCE. In this study we evaluated
Linlin Yang +4 more
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The sun, cholesterol and Orai1 conspire in melanoma
The EMBO Journal, 2022 How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca2+ influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma.
Woo Young Chung, Shmuel Muallem
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