Results 1 to 10 of about 7,709 (138)
STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria [PDF]
The EMBO JournalSTIM1 is a transmembrane protein localized in the endoplasmic reticulum (ER), where it acts as a calcium ion sensor, activating store-operated Ca2+ entry upon ER Ca2+ depletion.
Yolanda Orantos-Aguilera +7 more
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Biomolecules, 2021 Stromal interaction molecule 1 (STIM1) is the main protein that, along with Orai1, mediates store-operated Ca2+ entry (SOCE) in skeletal muscle. Abnormal SOCE due to mutations in STIM1 is one of the causes of human skeletal muscle diseases.
Ji Hee Park +3 more
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Frontiers in Physiology, 2021 Store-operated Ca2+ entry (SOCE) is an essential pathway for Ca2+ signaling, and regulates various vital cellular functions. It is triggered by the endoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1).
Yi-Ting Huang +7 more
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Visualisation and identification of the interaction between STIM1s in resting cells. [PDF]
PLoS ONE, 2012 Store-operated Ca(2+) channels are a major Ca(2+) entry pathway in nonexcitable cells, which drive various essential cellular functions. Recently, STIM1 and Orai proteins have been identified as the major molecular components of the Ca(2+) release ...
Jun He, Tao Yu, Jingying Pan, He Li
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Turkish Journal of Hematology, 2023 Objective: This study aimed to investigate the role of the stromal interaction molecule 1 (STIM1) gene in the survival of the acute myeloblastic leukemia (AML)-M5 cell line (THP-1). Materials and Methods: The STIM1 effect was assessed via dicersubstrate
Eman Salem Algariri +5 more
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Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. [PDF]
PLoS ONE, 2017 Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy.
Takayoshi Ohba +8 more
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S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
Life Science Alliance, 2023 This study shows that S417 of STIM1 plays an essential role in STIM1 C-terminus–Orai1 interaction and CRAC channel activation. It also presents new findings about 2-APB’s action on CRAC channel, which provides a tool for better understanding of SOCE ...
Tao Yu +6 more
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Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Spontaneously hypertensive rats of the stroke‐prone line (SHR‐A3) develop hypertensive renal disease as a result of naturally occurring genetic variation. Our prior work identified a single‐nucleotide polymorphism unique to SHR‐A3 that results
Isha S. Dhande +7 more
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Journal of Experimental & Clinical Cancer Research, 2023 Background Bone metastasis is a principal cause of mortality in patients with prostate cancer (PCa). Increasing evidence indicates that high expression of stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE) significantly ...
Qianghua Zhou +14 more
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Molecular Mechanism Analysis of STIM1 Thermal Sensation
Cells, 2023 STIM1 has been identified as a new warm sensor, but the exact molecular mechanism remains unclear. In this study, a variety of mutants of STIM1, Orai1 and Orai3 were generated.
Xiaoling Liu +6 more
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