Results 41 to 50 of about 7,759 (184)
STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions
Cell Reports, 2018 Summary: Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions.
Krishna Prasad Subedi +4 more
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Redox Biology, 2023 Vascular calcification is accelerated in patients with diabetes mellitus and increases risk of cardiovascular events and mortality. Vascular smooth muscle cells (VSMC) play a key role in regulating vascular tone and contribute significantly to the ...
Weiping Zhang +3 more
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Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle
JCI Insight, 2021 Stromal interaction molecule 1 (STIM1), the sarcoplasmic reticulum (SR) transmembrane protein, activates store-operated Ca2+ entry (SOCE) in skeletal muscle and, thereby, coordinates Ca2+ homeostasis, Ca2+-dependent gene expression, and contractility ...
Hengtao Zhang +9 more
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Molecules, 2023 Distant metastasis remains the primary cause of treatment failure and suggests a poor prognosis in nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) is a critical cellular process for initiating a tumor invasion and remote ...
Yue Luo +12 more
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Orai1, STIM1, and their associating partners
The Journal of Physiology, 2012 Abstract Store‐operated Ca2+ (SOC) entry is one of the major mechanisms to raise intracellular Ca2+ concentration in non‐excitable cells. Ca2+‐release‐activated Ca2+ (CRAC) channels are a subtype of SOC channels that are extensively characterized in immune cells.
Sonal, Srikanth, Yousang, Gwack
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Immunodeficiency due to mutations in ORAI1 and STIM1 [PDF]
Clinical Immunology, 2010 Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of ...
Stefan, Feske +2 more
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Stem Cell Research, 2014 Store-operated Ca2+ entry (SOCE) is an important Ca2+ influx pathway in non-excitable cells. STIM1, an ER Ca2+ sensor, and Orai1, a plasma membrane Ca2+ selective channel, are the two essential components of the Ca2+ release activated channel (CRAC ...
Baixia Hao +5 more
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TRPP2 and STIM1 form a microdomain to regulate store-operated Ca2+ entry and blood vessel tone
Cell Communication and Signaling, 2020 Background Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-operated Ca2+ entry (SOCE). Both
Jizheng Guo +7 more
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Molecular Metabolism, 2022 Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway.
Rebecca J. Wilson +10 more
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Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source