Results 41 to 50 of about 10,398 (215)

A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions [PDF]

Scientific Reports, 2016
AbstractSTIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER).
Jonathan Pacheco, Laura Dominguez, A. Bohórquez-Hernández, Alexander Asanov, Luis Vaca   +4 more
openaire   +2 more sources

The role of plasma membrane STIM1 and Ca2+entry in platelet aggregation. STIM1 binds to novel proteins in human platelets [PDF]

, 2014
Ca(2+) elevation is essential to platelet activation. STIM1 senses Ca(2+) in the endoplasmic reticulum and activates Orai channels allowing store-operated Ca(2+) entry (SOCE).
Ambily, A., Kaiser, W., Authi, K., Pierro, C., Li, Z., Kassouf, N., Gibbins, J., Chamberlain, E., Jones, C.   +8 more
core   +3 more sources

Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation

Cellular Physiology and Biochemistry, 2016
Background/Aims: Stromal interacting molecule-1 (STIM1) aggregation and redistribution to plasma membrane to interact with Orai1 constitute the core mechanism of store-operated Ca2+ entry (SOCE).
Lane Zhang, Limin Wang, Shu Li, Jingyi Xue, Dali Luo   +4 more
doaj   +1 more source

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle

Cells, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel, Jian Shi, William A. Large, Anthony P. Albert   +3 more
doaj   +1 more source

Regulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS).

PLoS ONE, 2010
The ubiquitin proteasome system (UPS) mediates the majority of protein degradation in eukaryotic cells. The UPS has recently emerged as a key degradation pathway involved in synapse development and function.
Jeffrey M Keil, Zhouxin Shen, Steven P Briggs, Gentry N Patrick   +3 more
doaj   +1 more source

STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: As an indispensable component of store-operated Ca2+ entry, stromal interaction molecule 1 (STIM1) is known to promote colorectal cancer and T-cell–mediated inflammatory diseases.
Xiaojing Liang, Jiansheng Xie, Hao Liu, Rongjie Zhao, Wei Zhang, Haidong Wang, Hongming Pan, Yubin Zhou, Weidong Han   +8 more
doaj   +1 more source

The STIM1–ORAI1 microdomain [PDF]

Cell Calcium, 2015
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2 ...
openaire   +2 more sources

Targeting Regulatory Pathways Of Stim1 In Nasopharyngeal Cancer [PDF]

, 2021
Stromal interaction molecule 1 (STIM1) is involved in various carcinogenic processes. However, the involvement and molecular implication of STIM1 in nasopharyngeal cancer (NPC) is not fully understood.
Imakwu, Okekpa Simon
core   +1 more source

STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

eLife, 2022
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs).
Vivek Krishnan, Sher Ali, Albert L Gonzales, Pratish Thakore, Caoimhin S Griffin, Evan Yamasaki, Michael G Alvarado, Martin T Johnson, Mohamed Trebak, Scott Earley   +9 more
doaj   +1 more source

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH [PDF]

, 2017
Ca release activated Ca (CRAC) channels composed of two cellular proteins, Ca-sensing stromal interaction molecule 1 (STIM1) and pore-forming Orai1, are the main mediators of the Ca entry pathway activated in response to depletion of intracellular Ca ...
Barritt, G., F. H. Zhou, G. J. Barritt, Zhou, FH, Rychkov, GY, Ma, L, Barritt, Gregory John, Whiley, David M, Gavriliouk, D, Zhou, F. H., Ma, L., S. Grigoryev, Rychkov, G. Y., Gavriliouk, D., Rychkov, G., Barritt, GJ, Barritt, G. J., N. R. Scrimgeour, G. Y. Rychkov, Gavriliouk, Dan, Ma, Lijia, Rychkov, Grigori Y, Scrimgeour, N., Zhou, David F H, Grigoryev, S, Grigoryev, Sergei A, Grigoryev, S., Zhou, F., Scrimgeour, Nathan, D. Gavriliouk, L. Ma, Scrimgeour, NR, Scrimgeour, N. R.   +32 more
core   +1 more source