Results 31 to 40 of about 10,398 (215)
Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. [PDF]
, 2020 BACKGROUND/AIMS Store-operated Ca2+ entry (SOCE) through plasma membrane Ca2+ channel Orai1 is essential for many cellular processes. SOCE, activated by ER Ca2+ store-depletion, relies on the gating function of STIM1 Orai1-activating region SOAR of ...
Augustynek, Bartlomiej S. +6 more
core +1 more source
Conformational dynamics of STIM1 activation [PDF]
Nature Structural & Molecular Biology, 2013 The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear.
Stefan, Feske, Murali, Prakriya
openaire +2 more sources
Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma. [PDF]
PLoS ONE, 2017 Calcium signal plays an important role in a variety of cancer cell metabolism, but knowledge on its role in head and neck squamous cell carcinoma (HNSCC) is limited. Store-operated calcium entry (SOCE) is the principal Ca2+ entry mechanism that maintains
Ping Li +8 more
doaj +1 more source
Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice
Frontiers in Physiology, 2023 Introduction: The intracellular Ca2+ sensor stromal interaction molecule 1 (STIM1) is thought to play a critical role in enamel development, as its mutations cause Amelogenesis Imperfecta (AI).
Raed Said +10 more
doaj +1 more source
The STIM1/Orai signaling machinery [PDF]
Channels, 2013 Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signaling pathway for T-cell activation as well as mast-cell degranulation. The ER-located Ca(2+)-sensor, STIM1 and the Ca(2+)-selective ion pore, Orai1 in the membrane are sufficient to fully reconstitute CRAC currents.
Fahrner, Marc +3 more
openaire +2 more sources
Pathogens, 2021 Epstein-Barr virus (EBV) promotes tumor angiogenesis in nasopharyngeal carcinoma (NPC) by activating store-operated Ca2+ entry. Since such entry has been linked to stromal interaction molecule 1 (STIM1), we examined whether the virus acts via STIM1 ...
Jiaxiang Ye +8 more
doaj +1 more source
Cell Calcium, 2019 A primary calcium (Ca2+) entry pathway into non-excitable cells is through the store-operated Ca2+ release activated Ca2+ (CRAC) channel. Ca2+ entry into cells is responsible for the initiation of diverse signalling cascades that affect essential cellular processes like gene regulation, cell growth and death, secretion and gene transcription.
Victoria Lunz +2 more
openaire +2 more sources
Journal of Inflammation Research, 2021 Jiang Zhu,1,* Xia Zhang,2,* Hong Xie,1 Yuye Wang,1 Xiaoxiao Zhang,1 Zhaoheng Lin3 1Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215008, Jiangsu, People’s Republic of China; 2Department of ...
Zhu J +5 more
doaj
TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
doaj +1 more source
Role of STIM1 in neurodegeneration
World Journal of Biological Chemistry, 2018 STIM1 is an endoplasmic reticulum (ER) protein with a key role in Ca2+ mobilization. Due to its ability to act as an ER-intraluminal Ca2+ sensor, it regulates store-operated Ca2+ entry (SOCE), which is a Ca2+ influx pathway involved in a wide variety of signalling pathways in eukaryotic cells.
Pascual-Caro, Carlos +3 more
openaire +2 more sources