Results 31 to 40 of about 7,759 (184)
Journal of Inflammation Research, 2021 Jiang Zhu,1,* Xia Zhang,2,* Hong Xie,1 Yuye Wang,1 Xiaoxiao Zhang,1 Zhaoheng Lin3 1Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215008, Jiangsu, People’s Republic of China; 2Department of ...
Zhu J +5 more
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Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation
Cellular Physiology and Biochemistry, 2016 Background/Aims: Stromal interacting molecule-1 (STIM1) aggregation and redistribution to plasma membrane to interact with Orai1 constitute the core mechanism of store-operated Ca2+ entry (SOCE).
Lane Zhang +4 more
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The STIM1–ORAI1 microdomain [PDF]
Cell Calcium, 2015 The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2 ...
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Regulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS).
PLoS ONE, 2010 The ubiquitin proteasome system (UPS) mediates the majority of protein degradation in eukaryotic cells. The UPS has recently emerged as a key degradation pathway involved in synapse development and function.
Jeffrey M Keil +3 more
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TRPC Channels in the SOCE Scenario
Cells, 2020 Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well
Jose J. Lopez +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: As an indispensable component of store-operated Ca2+ entry, stromal interaction molecule 1 (STIM1) is known to promote colorectal cancer and T-cell–mediated inflammatory diseases.
Xiaojing Liang +8 more
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Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle
Cells, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel +3 more
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STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
eLife, 2022 Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs).
Vivek Krishnan +9 more
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Cells, 2021 Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca2+.
Valentina Tedeschi +5 more
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POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters [PDF]
Proceedings of the National Academy of Sciences, 2011 Specialized proteins in the plasma membrane, endoplasmic reticulum (ER), and mitochondria tightly regulate intracellular calcium. A unique mechanism called store-operated calcium entry is activated when ER calcium is depleted, serving to restore intra-ER calcium levels.
Grigory, Krapivinsky +4 more
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