Results 11 to 20 of about 7,759 (184)
Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers [PDF]
Nature Communications, 2017 Store-operated calcium entry (SOCE) is elicited by the interaction of oligomerized STIM1 with plasma membrane Orai channels. Here, the authors show that this process is regulated by calmodulin, which binds STIM1 and disassembles the STIM1-Orai1 complex ...
Xin Li +8 more
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eLife, 2021 Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.
Marc Fahrner, Christoph Romanin
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The STIM1 Phosphorylation Saga
Cell Calcium, 2022 Store-operated Ca2+ entry (SOCE) is a Ca2+ influx pathway present in practically every cell type in metazoans and mediates a variety of physiological functions. Defects in SOCE are associated with immunodeficiencies and defects in skeletal muscle development and function.
Fang Yu, Khaled Machaca
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STIM1 in tumor cell death: angel or devil?
Cell Death Discovery, 2023 Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with tumor cell proliferation, metastasis ...
Ran Ren, Yongsheng Li
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An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Nature Communications, 2023 Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs
Yandong Zhou +10 more
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STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells
Cell Death and Disease, 2021 Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals.
Shunli Pan +11 more
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Cancer Biology & Medicine, 2022 Objective: The BRAF inhibitor, vemurafenib, has been widely used in the treatment of patients with melanoma-bearing BRAFV600E mutations. While the initial response to vemurafenib is usually excellent, the majority of patients eventually develop ...
Junling Shen +7 more
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The regulation of STIM1 by phosphorylation
Communicative & Integrative Biology, 2013 Calcium ion (Ca(2+)) concentration plays a key role in cell signaling in eukaryotic cells. At the cellular level, Ca(2+) directly participates in such diverse cellular events as adhesion and migration, differentiation, contraction, secretion, synaptic transmission, fertilization, and cell death.
Pozo-Guisado, Eulalia +1 more
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STIM1 and the noncapacitative ARC channels [PDF]
Cell Calcium, 2007 Our understanding of the nature and regulation of receptor-activated Ca(2+) entry in nonexcitable cells has recently undergone a radical change that began with the identification of the stromal interacting molecule proteins (e.g., STIM1) as playing a critical role in the regulation of the capacitative, or store-operated, Ca(2+) entry.
Trevor J, Shuttleworth +2 more
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Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma. [PDF]
PLoS ONE, 2017 Calcium signal plays an important role in a variety of cancer cell metabolism, but knowledge on its role in head and neck squamous cell carcinoma (HNSCC) is limited. Store-operated calcium entry (SOCE) is the principal Ca2+ entry mechanism that maintains
Ping Li +8 more
doaj +1 more source