Results 21 to 30 of about 10,398 (215)
STIM1 in tumor cell death: angel or devil?
Cell Death Discovery, 2023 Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with tumor cell proliferation, metastasis ...
Ran Ren, Yongsheng Li
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An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Nature Communications, 2023 Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His aromatic pairs
Yandong Zhou +10 more
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Cancer Biology & Medicine, 2022 Objective: The BRAF inhibitor, vemurafenib, has been widely used in the treatment of patients with melanoma-bearing BRAFV600E mutations. While the initial response to vemurafenib is usually excellent, the majority of patients eventually develop ...
Junling Shen +7 more
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STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells
Cell Death and Disease, 2021 Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals.
Shunli Pan +11 more
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A novel STIM1-Orai1 gating interface essential for CRAC channel activation. [PDF]
, 2019 Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel.
Muik, Martin +12 more
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, 2023 Black squares, affected males; black circles, affected females; crossed out black circle, affected female deceased; white squares and circles, unaffected males and females, respectively.
Elena Pegoraro (289281) +6 more
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The regulation of STIM1 by phosphorylation
Communicative & Integrative Biology, 2013 Calcium ion (Ca(2+)) concentration plays a key role in cell signaling in eukaryotic cells. At the cellular level, Ca(2+) directly participates in such diverse cellular events as adhesion and migration, differentiation, contraction, secretion, synaptic transmission, fertilization, and cell death.
Pozo-Guisado, Eulalia +1 more
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PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
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STIM1 and the noncapacitative ARC channels [PDF]
Cell Calcium, 2007 Our understanding of the nature and regulation of receptor-activated Ca(2+) entry in nonexcitable cells has recently undergone a radical change that began with the identification of the stromal interacting molecule proteins (e.g., STIM1) as playing a critical role in the regulation of the capacitative, or store-operated, Ca(2+) entry.
Trevor J, Shuttleworth +2 more
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ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Rainer Schreiber +13 more
core +1 more source