Results 21 to 30 of about 7,759 (184)
PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
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FEBS Letters, 2015 Store‐operated calcium entry (SOCE) is a pathway that moves Ca2+ across the plasma membrane and is mediated by two major proteins, STIM1 and Orai1. Here, we discovered that the cytoplasmic domain of STIM1 is a target for calpains, a family of Ca2+‐activated proteases.
Prins, Daniel, Michalak, Marek
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Conformational dynamics of STIM1 activation [PDF]
Nature Structural & Molecular Biology, 2013 The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear.
Stefan, Feske, Murali, Prakriya
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Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice
Frontiers in Physiology, 2023 Introduction: The intracellular Ca2+ sensor stromal interaction molecule 1 (STIM1) is thought to play a critical role in enamel development, as its mutations cause Amelogenesis Imperfecta (AI).
Raed Said +10 more
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Cell Calcium, 2019 A primary calcium (Ca2+) entry pathway into non-excitable cells is through the store-operated Ca2+ release activated Ca2+ (CRAC) channel. Ca2+ entry into cells is responsible for the initiation of diverse signalling cascades that affect essential cellular processes like gene regulation, cell growth and death, secretion and gene transcription.
Victoria Lunz +2 more
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The STIM1/Orai signaling machinery [PDF]
Channels, 2013 Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signaling pathway for T-cell activation as well as mast-cell degranulation. The ER-located Ca(2+)-sensor, STIM1 and the Ca(2+)-selective ion pore, Orai1 in the membrane are sufficient to fully reconstitute CRAC currents.
Fahrner, Marc +3 more
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Pathogens, 2021 Epstein-Barr virus (EBV) promotes tumor angiogenesis in nasopharyngeal carcinoma (NPC) by activating store-operated Ca2+ entry. Since such entry has been linked to stromal interaction molecule 1 (STIM1), we examined whether the virus acts via STIM1 ...
Jiaxiang Ye +8 more
doaj +1 more source
Role of STIM1 in neurodegeneration
World Journal of Biological Chemistry, 2018 STIM1 is an endoplasmic reticulum (ER) protein with a key role in Ca2+ mobilization. Due to its ability to act as an ER-intraluminal Ca2+ sensor, it regulates store-operated Ca2+ entry (SOCE), which is a Ca2+ influx pathway involved in a wide variety of signalling pathways in eukaryotic cells.
Pascual-Caro, Carlos +3 more
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A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions [PDF]
Scientific Reports, 2016 AbstractSTIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER).
Jonathan Pacheco +4 more
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STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry [PDF]
Scientific Reports, 2017 AbstractStore-operated Ca2+ entry (SOCE) mediates the increase in intracellular calcium (Ca2+) in endothelial cells (ECs) that regulates several EC functions including tissue-fluid homeostasis. Stromal-interaction molecule 1 (STIM1), upon sensing the depletion of (Ca2+) from the endoplasmic reticulum (ER) store, organizes as puncta that trigger store ...
Pascal Yazbeck +7 more
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