Results 51 to 60 of about 7,759 (184)
Immunolocalization of STIM1 in the mouse brain
Acta Neurobiologiae Experimentalis, 2009 Capacitative Calcium Entry (CCE) in neurons seems to depend, as in non-excitatory cells, on endoplasmic reticulum calcium sensors STIM1 or STIM2. We show localization of STIM1 in the mouse brain by immunohistochemistry with a specific antibody. STIM1 immunoreactivity has wide, but not uniform, distribution throughout the brain and is observed in ...
Anna, Skibinska-Kijek +4 more
openaire +2 more sources
From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. [PDF]
PLoS ONE, 2011 The interaction between Ca(2+) sensors STIM1 and STIM2 and Ca(2+) channel-forming protein ORAI1 is a crucial element of store-operated calcium entry (SOCE) in non-excitable cells. However, the molecular mechanism of SOCE in neurons remains unclear.
Joanna Gruszczynska-Biegala +3 more
doaj +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
Role of STIM1 in the surface expression of SARAF [PDF]
Channels, 2016 The store-operated Ca2+ entry-associated regulatory factor (SARAF), a protein expressed both in the endoplasmic reticulum and the plasma membrane, has been presented as a STIM1-interacting protein with the ability to modulate intracellular Ca2+ homeostasis.
Albarrán Alonso, Letizia +4 more
openaire +3 more sources
STIM1 Is a Novel Component of ER-Chlamydia trachomatis Inclusion Membrane Contact Sites.
PLoS ONE, 2015 Productive developmental cycle of the obligate intracellular bacterial pathogen Chlamydia trachomatis depends on the interaction of the replicative vacuole, named the inclusion, with cellular organelles.
Hervé Agaisse, Isabelle Derré
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley +1 more source
STIM1 (c)AMPs up melanogenesis [PDF]
The EMBO Journal, 2018 STIM1 and STIM2 are endoplasmic reticulum Ca 2+ sensors that serve multi‐faceted roles in signal transduction in a wide variety of different cell types. In this issue of The EMBO Journal , Motiani et al define and characterize the ability of STIM1 to control cAMP generation in a new context, melanin production (Motiani et al , 2018), offering new ...
Jonathan Soboloff +2 more
openaire +2 more sources
MicroRNA-223 Targeting STIM1 Inhibits the Biological Behavior of Breast Cancer
Cellular Physiology and Biochemistry, 2018 Background/Aims: To investigate the cellular effects and clinical significance of microRNA-223 (miR-223) in breast cancer by targeting stromal interaction molecule1 (STIM1).
Yanfang Yang +6 more
doaj +1 more source