Results 51 to 60 of about 10,398 (215)
Cells, 2021 Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca2+.
Valentina Tedeschi +5 more
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STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions
Cell Reports, 2018 Summary: Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions.
Krishna Prasad Subedi +4 more
doaj +1 more source
Molecules, 2023 Distant metastasis remains the primary cause of treatment failure and suggests a poor prognosis in nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) is a critical cellular process for initiating a tumor invasion and remote ...
Yue Luo +12 more
doaj +1 more source
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. [PDF]
, 2008 2-Aminoethoxydiphenyl borate (2-APB) has emerged as a useful pharmacological tool in the study of store-operated Ca(2+) entry (SOCE). It has been shown to potentiate store-operated Ca(2+) release-activated Ca(2+) (CRAC) currents at low micromolar ...
Penner, Reinhold +4 more
core +1 more source
α-SNAP binds to the CC3 domain of Stim1.
, 2021 (A)In vitro binding of α-SNAP to MBP-tagged CAD and its sub-domains Stim1 344–382 and Stim1 408–442. (Top) Ponceau S staining showing the input of MBP-tagged fragments.
Yong Miao (380871) +2 more
core +1 more source
Orai1, STIM1, and their associating partners
The Journal of Physiology, 2012 Abstract Store‐operated Ca2+ (SOC) entry is one of the major mechanisms to raise intracellular Ca2+ concentration in non‐excitable cells. Ca2+‐release‐activated Ca2+ (CRAC) channels are a subtype of SOC channels that are extensively characterized in immune cells.
Sonal, Srikanth, Yousang, Gwack
openaire +3 more sources
Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle
JCI Insight, 2021 Stromal interaction molecule 1 (STIM1), the sarcoplasmic reticulum (SR) transmembrane protein, activates store-operated Ca2+ entry (SOCE) in skeletal muscle and, thereby, coordinates Ca2+ homeostasis, Ca2+-dependent gene expression, and contractility ...
Hengtao Zhang +9 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway.
Rebecca J. Wilson +10 more
doaj +1 more source
Immunolocalization of STIM1 in the mouse brain
Acta Neurobiologiae Experimentalis, 2009 Capacitative Calcium Entry (CCE) in neurons seems to depend, as in non-excitatory cells, on endoplasmic reticulum calcium sensors STIM1 or STIM2. We show localization of STIM1 in the mouse brain by immunohistochemistry with a specific antibody. STIM1 immunoreactivity has wide, but not uniform, distribution throughout the brain and is observed in ...
Anna, Skibinska-Kijek +4 more
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TRPP2 and STIM1 form a microdomain to regulate store-operated Ca2+ entry and blood vessel tone
Cell Communication and Signaling, 2020 Background Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-operated Ca2+ entry (SOCE). Both
Jizheng Guo +7 more
doaj +1 more source