Results 71 to 80 of about 7,759 (184)
European Journal of Immunology, Volume 56, Issue 7, July 2026.Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa +3 more
wiley +1 more source
British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
STIM1 in Rat Ventricular Myocytes [PDF]
Biophysical Journal, 2011 The Ca2+ binding protein STIM1 is located primarily in the sarcoplasmic and endoplasmic reticulum. It is thought that STIM1 plays a critical role in activating Ca2+ release activated Ca2+ channel (CRAC) in non-excitable cells such as T lymphocytes and may also be important in excitable cells such as skeletal muscle and smooth muscle cells.
Zhao, Guiling, Lederer, W. Jonathan
openaire +1 more source
Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem +2 more
wiley +1 more source
STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression
Cancer Biology & Medicine, 2019 Objective Stromal interaction molecule 1 (STIM1) overexpression has been reported to play an important role in progression of several cancers. However, the mechanism of STIM1 overexpression and its relationship with hypoxia in pancreatic ductal ...
Jian Wang +5 more
doaj +1 more source
Biomedical Chromatography, Volume 40, Issue 6, June 2026.ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang +3 more
wiley +1 more source
Nanoparticles in Vascular Dementia: Advantages and Challenges
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu +8 more
wiley +1 more source
Amplification of CRAC current by STIM1 and CRACM1 (Orai1) [PDF]
Nature Cell Biology, 2006 Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for ...
Christine, Peinelt +9 more
openaire +2 more sources
The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. [PDF]
PLoS ONE, 2013 Store-operated Ca(2+) entry (SOCE) is a critical Ca(2+) signaling pathway in many cell types. After sensing Ca(2+) store depletion in the endoplasmic reticulum (ER) lumen, STIM1 (STromal Interaction Molecule 1) oligomerizes and then interacts with and ...
Boyang Cui +6 more
doaj +1 more source
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source