Results 71 to 80 of about 10,398 (215)
STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration [PDF]
, 2015 STIM1 is a key regulator of store-operated calcium entry (SOCE), and therefore a mediator of Ca2+ entry-dependent cellular events. Phosphorylation of STIM1 at ERK1/2 target sites has been described as enhancing STIM1 activation during intracellular Ca2 ...
Casas-Rua, Vanessa +5 more
core +2 more sources
Immunodeficiency due to mutations in ORAI1 and STIM1 [PDF]
Clinical Immunology, 2010 Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of ...
Stefan, Feske +2 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 53, 24 September 2026.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source
STIM1 (c)AMPs up melanogenesis [PDF]
The EMBO Journal, 2018 STIM1 and STIM2 are endoplasmic reticulum Ca 2+ sensors that serve multi‐faceted roles in signal transduction in a wide variety of different cell types. In this issue of The EMBO Journal , Motiani et al define and characterize the ability of STIM1 to control cAMP generation in a new context, melanin production (Motiani et al , 2018), offering new ...
Jonathan Soboloff +2 more
openaire +2 more sources
MicroRNA-223 Targeting STIM1 Inhibits the Biological Behavior of Breast Cancer
Cellular Physiology and Biochemistry, 2018 Background/Aims: To investigate the cellular effects and clinical significance of microRNA-223 (miR-223) in breast cancer by targeting stromal interaction molecule1 (STIM1).
Yanfang Yang +6 more
doaj +1 more source
Glia, Volume 74, Issue 9, September 2026.Astrocytic TREK‐1‐dependent volume transients contribute to hippocampal synaptic plasticity and memory formation. TRPA1‐mediated astrocytic calcium signaling is required for long‐term potentiation, while astrocytic BDNF is necessary and sufficient to support sustained synaptic plasticity.
Victor James Drew +6 more
wiley +1 more source
A cholesterol interaction domain in STIM1 is important for STIM1‐Orai1 coupling (LB53)
The FASEB Journal, 2014 STIM1 and Orai1 are the basic components of the calcium influx pathway known as store‐operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum. The activation of Orai1 requires the direct coupling of STIM1 domain known as SOAR (Stim Orai Activating
Jonathan Pacheco, Luis Vaca
openaire +1 more source
Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation
Cells, 2021 Stromal interaction molecule 1 (STIM1) resides primarily in the sarco/endoplasmic reticulum, where it senses intraluminal Ca2+ levels and activates Orai channels on the plasma membrane to initiate Ca2+ influx.
Jesse Gammons +2 more
doaj +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, Volume 74, Issue S1, Page S58-S64, September 2026.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
STIM1 suppression inhibits egress of eVP40 VLPs.
, 2015 A. VP40 was expressed in control and STIM1 suppressed HEK293T cells as indicated and eVP40 VLP production quantified by immunoblot analysis demonstrates significant inhibition of eVP40 production in STIM1 suppressed cells (n = 4 independent experiments).
Ronald N. Harty (819814) +13 more
core +1 more source