Results 81 to 90 of about 7,759 (184)

TRPC channels function independently of STIM1 and Orai1 [PDF]

The Journal of Physiology, 2009
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca2+‐release activated Ca2+ (CRAC) channels, channels underlying store‐operated Ca2+ entry (SOCE). In addition, these proteins have been suggested to function in signalling and constructing other channels with biophysical properties distinct ...
Wayne I, DeHaven, Bertina F, Jones, John G, Petranka, Jeremy T, Smyth, Takuro, Tomita, Gary S, Bird, James W, Putney   +6 more
openaire   +2 more sources

Key Components of Store-Operated Ca2+ Entry in Non-Excitable Cells

Journal of Pharmacological Sciences, 2014
.: Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ entry pathway in non-excitable cells. It is activated by the depletion of Ca2+ from intracellular Ca2+ stores, notably the endoplasmic reticulum (ER).
Yosuke Tojyo, Takao Morita, Akihiro Nezu, Akihiko Tanimura   +3 more
doaj   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis

Smart Medicine, Volume 5, Issue 3, June 2026.
Magnetic fields modulate macrophage‐cancer crosstalk through the STING‐TRPC1 axis. Exposure reprograms macrophages toward the anti‐cancer phenotype. Exposing cancer cells modulates cancer secretome to promote polarization and selective recruitment of M1‐tumoricidal macrophages, enhancing cancer immunogenicity.
Viresh Krishnan Sukumar, Yee Kit Tai, Jan Nikolas Iversen, Olivia Yeo, Anisha Praiselin Paul, Kwan Yu Wu, Lina Hsiu Kim Lim, Alfredo Franco‐Obregón   +7 more
wiley   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled Phase 1 Study of Adiponectin Agonist (PEG)‐BHD1028 in People With Insulin Resistance

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Low adiponectin levels may contribute to insulin resistance. This first‐in‐human study evaluated adiponectin receptor agonist (PEG)‐BHD1028 in subjects with insulin resistance. Adults with BMI ≥ 27 kg/m2, HOMA‐IR ≥ 1.8, and HbA1c < 6.5% received subcutaneous injections of (PEG)‐BHD1028 or placebo in single‐ascending dose (SAD) cohorts (4, 8 ...
Pablo Lapuerta, Brian B. Kim
wiley   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk, Andre Zeug, Franziska E. Müller   +2 more
wiley   +1 more source

STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance

Cellular Physiology and Biochemistry, 2016
Background/AIM: STIM1 is as an essential component in store operated Ca2+ entry. However give the paucity of information on the role of STIM1 in kidney, the aim was to study the function of STIM1 in the medulla of the kidney.
Liudmila Cebotaru, Valeriu Cebotaru, Hua Wang, Lois J. Arend, William B. Guggino   +4 more
doaj   +1 more source

Calcium sensing by the STIM1 ER-luminal domain

Nature Communications, 2018
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological ...
Aparna Gudlur, Ana Eliza Zeraik, Nupura Hirve, V. Rajanikanth, Andrey A. Bobkov, Guolin Ma, Sisi Zheng, Youjun Wang, Yubin Zhou, Elizabeth A. Komives, Patrick G. Hogan   +10 more
doaj   +1 more source

STIM1 strengthens clotting

The Journal of Experimental Medicine, 2008
On page 1583, Varga-Szabo et al. show that platelets missing a calcium channel opener build puny, feeble clots that may actually save lives. Figure 1 Vessel-blocking clots (top) are avoided when platelets lack STIM1 (bottom). Platelets require calcium to initiate clotting in response to extracellular cues.
openaire   +2 more sources

STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1

Cell Reports, 2015
Hypoxia and intracellular Ca2+ transients are fundamental traits of cancer, whereas the route and regulation of Ca2+ mobilization in hypoxic tumorigenesis are unknown.
Yongsheng Li, Bo Guo, Qichao Xie, Duyun Ye, Dongxin Zhang, Ying Zhu, Hongxiang Chen, Bo Zhu   +7 more
doaj   +1 more source