Results 81 to 90 of about 10,398 (215)
STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry
Cell Calcium, 2020 During myogenesis, a long splice variant of STIM1, called STIM1L is getting expressed, while the level of STIM1 remains constant. Previous work demonstrated that STIM1L is more efficient in eliciting store-operated Ca2+ entry (SOCE), but no current analysis of the channel(s) activated by this new STIM1L isoform was performed until now.
Dyrda, Agnieszka +2 more
openaire +4 more sources
FASEB BioAdvances, Volume 8, Issue 9, September 2026.Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar +1 more
wiley +1 more source
Understanding the STIM1-ulous [PDF]
Science, 2013 Signal Transduction![Figure][1] CREDIT: ALEJANDRO P. ADAM, PETER A. VINCENT, AND MOHAMED TREBAK The permeability of the circulatory system is carefully regulated, and disruption of the barrier can contribute to inflammation and sepsis. One important means of regulation is the action of thrombin on vascular endothelial cells.
openaire +1 more source
TRPC channels as STIM1-regulated SOCs [PDF]
Channels, 2009 Store-operated Ca(2+) channels (SOCs) are Ca(2+) influx channels at the plasma membrane whose opening is determined by the level of Ca(2+) stored in the endoplasmic reticulum lumen. SOCs are activated in response to receptor-mediated or passive depletion of ER Ca(2+) to regulate many Ca(2+)-dependent cellular functions.
Joseph P, Yuan +6 more
openaire +2 more sources
The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites
Cell Reports, 2023 Summary: Depletion of Ca2+ from the endoplasmic reticulum (ER) causes the ER Ca2+ sensor STIM1 to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM MCS, STIM1 binds to Orai channels to induce cellular Ca2+ entry.
Hadas Achildiev Cohen +4 more
doaj +1 more source
Listening to the quiescence of single STIM1 dimers. [PDF]
Proc Natl Acad Sci U S AHogan PG.
europepmc +4 more sources
SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Metastatic colon cancer remains a significant clinical challenge, often associated with poor patient prognosis. Recent studies have identified the secreted frizzled‐related protein 2 (SFRP2) as a key player in this malignancy, showing its overexpression in metastatic cases.
Yanshen Kuang +6 more
wiley +1 more source
STIM1 regulates store-operated Ca2+ entry in oocytes [PDF]
, 2009 The single transmembrane-spanning Ca2+-binding protein, STIM1, has been proposed to function as a Ca2+ sensor that links the endoplasmic reticulum to the activation of store-operated Ca2+ channels.
Cabot, Ryan A. +4 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.In multiple sclerosis, astrocytes detect extracellular DNA via the cGAS–STING pathway, triggering Clusterin secretion that induces oligodendrocyte apoptosis and demyelination. Pharmacological STING inhibition with H‐151 suppresses this neurotoxic cascade, preserves myelin integrity, and ameliorates clinical disability in experimental autoimmune ...
Shengfei Hu +11 more
wiley +1 more source
Western blot analysis of STIM1.
, 2014 A) Western blotting was performed as described in the Materials and Methods. The size of STIM1 in SHRSP was obviously smaller than that in WKY. A representative data is shown. B) Semi-quantitative evaluation of the STIM1 protein level was performed using
Bing Xiao (158836) +8 more
core +1 more source