Results 101 to 110 of about 10,398 (215)
European Journal of Immunology, Volume 56, Issue 7, July 2026.Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa +3 more
wiley +1 more source
Expression of STIM1 and Orai1 in melanoma.
, 2014 (A and B) Western blot analyses of STIM1 (A) and Orai1 (B) expression in the indicated cell lines. (C) Immunohistochemical stainings of HE, MART1, STIM1 (the antibody from Abnova was used) and Orai1 (the antibody from Sigma was used) in a melanoma tissue
Lai-Hua Xie (61988) +14 more
core +1 more source
British Journal of Haematology, Volume 209, Issue 1, Page 16-27, July 2026.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem +2 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 6, June 2026.ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang +3 more
wiley +1 more source
STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance
Cellular Physiology and Biochemistry, 2016 Background/AIM: STIM1 is as an essential component in store operated Ca2+ entry. However give the paucity of information on the role of STIM1 in kidney, the aim was to study the function of STIM1 in the medulla of the kidney.
Liudmila Cebotaru +4 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
The regulation of STIM1 translocation to the plasma membrane [PDF]
A rise in intracellular Ca2+ concentration is key to controlling both short term and long term Ca2+ dependent processes which include secretion, metabolism and gene expression, cell growth and proliferation. Store operated Ca2+ channels (SOCs), which are
Walsh, Ciara
core +1 more source
Calcium sensing by the STIM1 ER-luminal domain
Nature Communications, 2018 Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca2 + levels to maintain cellular Ca2 + balance. Here the authors find that the STIM1 luminal domain monomer has multiple Ca2 + - binding sites which set the threshold for physiological ...
Aparna Gudlur +10 more
doaj +1 more source
The Journal of Experimental Medicine, 2008 On page 1583, Varga-Szabo et al. show that platelets missing a calcium channel opener build puny, feeble clots that may actually save lives. Figure 1 Vessel-blocking clots (top) are avoided when platelets lack STIM1 (bottom). Platelets require calcium to initiate clotting in response to extracellular cues.
openaire +2 more sources