Results 121 to 130 of about 10,398 (215)

Deciphering the role of STIM1 in nervous system development

, 2017
The wiring of the nervous system during development requires each neuron to find and connect with a correct synaptic target in a process known as axon pathfinding. Defects in axon pathfinding cause significant neurodevelopmental disorders, and contribute
Thompson, AC (15936440)
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Loss of STIM1 and STIM2 in Salivary Glands Disrupts ANO1 Function but Does Not Induce Sjogren’s Disease

Function
Ca2+ signaling via the store-operated Ca2+ entry (SOCE) mediated by STIM1 and STIM2 proteins and the ORAI1 Ca2+ channel is important in saliva fluid secretion and has been associated with Sjogren’s disease (SjD).
Ga-Yeon Son, Anna Zou, Amanda Wahl, Kai Ting Huang, Saruul Zorgit, Manikandan Vinu, Fang Zhou, Larry Wagner, Youssef Idaghdour, David I Yule, Stefan Feske, Rodrigo S Lacruz   +11 more
doaj   +1 more source

STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels

, 2006
Receptor-evoked Ca2+ signalling involves Ca2+ release from the endoplasmic reticulum, followed by Ca2+ influx across the plasma membrane. Ca2+ influx is essential for many cellular functions, from secretion to transcription, and is mediated by Ca2 ...
김주영
core   +1 more source

EB1 traps STIM1 and regulates local store-operated Ca2+ entry

, 2018
STIM1 activates store-operated Ca2+ entry when Ca2+ in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER
Tie-Shan Tang, Qiao-Chu Wang, Xi Wang
core   +1 more source

STIM1, ORAI1, and KDM2B in circulating tumor cells (CTCs) isolated from prostate cancer patients

Frontiers in Cell and Developmental Biology
Introduction: Previous publications have shown that STIM1, ORAI1, and KDM2B, are implicated in Ca2+ signaling and are highly expressed in various cancer subtypes including prostate cancer.
Argyro Roumeliotou, Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Christos Stournaras, Galatea Kallergi   +5 more
doaj   +1 more source

Expression of STIM1, STIM2, and Orai1.

, 2013
A: Expression of STIM1, STIM2, Orai1, and GAPDH mRNAs detected by RT-PCR in human airway smooth muscle (ASM) cells is shown. Negative indicates a negative control.
Satoru Ito (283410), Yoshinori Hasegawa (308240), Masahiro Sokabe (308239), Masashi Kondo (308237), Nobukazu Suganuma (308235), Hiromichi Aso (308236), Mitsuo Sato (67131)   +6 more
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STIM1 is enriched at ER-Inclusion MCSs.

, 2015
Electron micrographs of HeLa cells expressing HRP-STIM1, infected with C. trachomatis for 24h and processed for conventional transmission electron microscopy coupled with peroxidase cytochemistry.
Isabelle Derré (80082), Hervé Agaisse (80085)   +1 more
core   +1 more source

A novel bi-allelic loss-of-function mutation in STIM1 expands the phenotype of STIM1-related diseases

, 2021
International audienceSTIM1, the stromal interaction molecule 1, is the key protein for maintaining calciumconcentration in the endoplasmic reticulum by triggering the Store Operated CalciumEntry (SOCE). Bi-allelic mutations in STIM1 gene are responsible
Salvi, Alexandra, Delague, Valérie, Cristina, Skrypnyk, Urtizberea, Jon Andoni, Levy, Nicolas, Bartoli, Marc, Mégarbané, André, Robert, Catherine, Moiz, Bakhiet, da Silva, Nathalie   +9 more
core  

STIM1 regulates pancreatic β-cell behaviour: A modelling study

Pancreatic β-cells are equipped with the molecular machinery allowing them to respond to high glucose levels in the form of electrical activity and Ca2+ oscillations. These oscillations drive insulin secretion.
Dupont, Geneviève, Romero Campos, Hugo H.E., Gonzalez-Velez, Virginia   +2 more
core   +1 more source

STIM1 Gene [PDF]

, 2020
openaire   +1 more source