Results 91 to 100 of about 10,398 (215)

STIM1 in Rat Ventricular Myocytes [PDF]

Biophysical Journal, 2011
The Ca2+ binding protein STIM1 is located primarily in the sarcoplasmic and endoplasmic reticulum. It is thought that STIM1 plays a critical role in activating Ca2+ release activated Ca2+ channel (CRAC) in non-excitable cells such as T lymphocytes and may also be important in excitable cells such as skeletal muscle and smooth muscle cells.
Zhao, Guiling, Lederer, W. Jonathan
openaire   +1 more source

Ryanodine Receptor 1 Is Dispensable for CD4+ T‐Cell Differentiation and Effector Function in Intestinal Inflammation Models

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation.
Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Phillip Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber   +14 more
wiley   +1 more source

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

, 2010
et al.Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma membrane Orai1 channels in response to decreased Ca2+ concentrations in the endoplasmic reticulum lumen. We identified an acidic motif within the STIM1 coiled-
Manjarrés, Isabel M., Korzeniowski, Marek K.   +1 more
core   +2 more sources

STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression

Cancer Biology & Medicine, 2019
Objective Stromal interaction molecule 1 (STIM1) overexpression has been reported to play an important role in progression of several cancers. However, the mechanism of STIM1 overexpression and its relationship with hypoxia in pancreatic ductal ...
Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong, Jianwei Sun   +5 more
doaj   +1 more source

The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1. [PDF]

PLoS ONE, 2013
Store-operated Ca(2+) entry (SOCE) is a critical Ca(2+) signaling pathway in many cell types. After sensing Ca(2+) store depletion in the endoplasmic reticulum (ER) lumen, STIM1 (STromal Interaction Molecule 1) oligomerizes and then interacts with and ...
Boyang Cui, Xue Yang, Siwei Li, Zhijie Lin, Zheng Wang, Cheng Dong, Yuequan Shen   +6 more
doaj   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

α-SNAP binds Stim1 with high affinity.

, 2021
(A) SDS-PAGE showing purified human Stim1 336–485. (B) CD spectra of purified Stim1 336–485. (C) SDS-PAGE showing Avi-Tagged human α-SNAP expressed, purified and biotinylated using BirA ligase. (D) CD spectra of purified and biotinylated human α-SNAP. (E)
Yong Miao (380871), Ramanagouda Ramanagoudr-Bhojappa (1345893), Monika Vig (8136918)   +2 more
core   +1 more source

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Chronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as “secondary‐hits” believed to worsen cognitive decline.
Chang Liu, Kimia Sakha, Jaime Anton, Alfredo Cardenas‐Rivera, Mohammad A. Yaseen   +4 more
wiley   +1 more source

TRPC channels function independently of STIM1 and Orai1 [PDF]

The Journal of Physiology, 2009
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca2+‐release activated Ca2+ (CRAC) channels, channels underlying store‐operated Ca2+ entry (SOCE). In addition, these proteins have been suggested to function in signalling and constructing other channels with biophysical properties distinct ...
Wayne I, DeHaven, Bertina F, Jones, John G, Petranka, Jeremy T, Smyth, Takuro, Tomita, Gary S, Bird, James W, Putney   +6 more
openaire   +2 more sources

Key Components of Store-Operated Ca2+ Entry in Non-Excitable Cells

Journal of Pharmacological Sciences, 2014
.: Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ entry pathway in non-excitable cells. It is activated by the depletion of Ca2+ from intracellular Ca2+ stores, notably the endoplasmic reticulum (ER).
Yosuke Tojyo, Takao Morita, Akihiro Nezu, Akihiko Tanimura   +3 more
doaj   +1 more source