Results 71 to 80 of about 8,832 (217)
Cross-linking of Orai1 channels by STIM proteins [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance The work presents a unique understanding of the organization and function of two ubiquitously expressed proteins, central in generating calcium signals in all cell types. These are the intracellular calcium sensing “STIM” proteins, and the highly selective cell surface “Orai” calcium channels. We reveal that STIM proteins
Yandong Zhou +9 more
openaire +2 more sources
STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions
Cell Reports, 2018 Summary: Ca2+ entry mediated by the calcium channel, Orai1, provides critical Ca2+ signals that regulate cell function. The ER-Ca2+ sensor protein, STIM1, recruits and strongly activates Orai1 within ER-PM junctions.
Krishna Prasad Subedi +4 more
doaj +1 more source
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle
Cells, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel +3 more
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck +13 more
wiley +1 more source
Sestrin2 interacts and regulates Orai1 calcium channels [PDF]
, 2020 Department of Biological SciencesStore-operated Ca2+ entry (SOCE) is based on the interaction of endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) with the Orai1 Ca2+ channel which is located in plasma membrane.
Jang, Ki Hyun
core
ORAI1 Ca2+ Channels Control Endothelin-1-Induced Mitogenesis and Melanogenesis in Primary Human Melanocytes [PDF]
, 2012 UV radiation of the skin triggers keratinocytes to secrete endothelin-1 (ET-1) that binds to endothelin receptors on neighboring melanocytes. Melanocytes respond with a prolonged increase in intracellular Ca2þ concentration ([Ca2þ]i), which is ...
Stark, Alexandra +12 more
core +2 more sources
Relationship between DOX, p53, and ORAI1 in CFs.
, 2022 DOX increased the expression of p53 and induced apoptosis, cell cycle arrest, and ROS production. In addition, DOX increased the expression of ORAI1, not STIM1.
Fumina Suzuki (14227640) +10 more
core +1 more source
Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry [PDF]
, 2016 Ca2+ influx by store-operated Ca2+ channels is a major mechanism for intracellular Ca2+ homeostasis and cellular function. Here we present evidence for the dynamic interaction between the SOCE-associated regulatory factor (SARAF), STIM1 and Orai1.
Martin-Cano, Francisco E. +6 more
core +2 more sources
Frontiers in Physiology, 2021 Aims: The underlying mechanism of diabetic enteropathy, a common complication of type 1 diabetes, remains unclear. Store-operated Ca2+ entry (SOCE) is a ubiquitous type of Ca2+ influx involved in various cellular functions.
Fang Dai +9 more
doaj +1 more source