Results 71 to 80 of about 6,378 (182)

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The calcium (Ca2+) channel Orai1—the pore‐forming subunit of the Ca2+ release‐activated Ca2+ channel—is opened by its physiological activator, the endoplasmic reticulum (ER)‐resident Ca2+ sensor stromal interaction molecule 1 (STIM1) upon ER Ca2+ store‐depletion.
Maximilian Fröhlich, Tamara Radišković, Valentina Hopl, Magdalena Prantl, Hadil Najjar, Selina Harant, Diana Thallinger, Muhammad Shehzad Anwar, Ferdinand Horvath, Julia Söllner, Yuliia Nazarenko, Matthias Sallinger, Nora Müller, Adéla Tiffner, Sarah Weiß, Herwig Grabmayr, Heinrich Krobath, Isabella Derler   +17 more
wiley   +1 more source

Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology, 2017
Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal.
Lei Wang, Jiaqi Hao, Yijian Zhang, Ziyi Yang, Yang Cao, Wei Lu, Yijun Shu, Lin Jiang, Yunping Hu, Wenjie Lv, Yingbin Liu, Ping Dong   +11 more
doaj   +1 more source

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells

Cells, 2020
Being the largest the Ca2+ store in mammalian cells, endoplasmic reticulum (ER)-mediated Ca2+ signalling often involves both Ca2+ release via inositol 1, 4, 5-trisphosphate receptors (IP3R) and store operated Ca2+ entries (SOCE) through Ca2+ release ...
Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L. Gill, Shengcheng Han, Youjun Wang   +11 more
doaj   +1 more source

The exquisitely cooperative nature of Orai1 channel activation [PDF]

Journal of General Physiology, 2018
Yeung and Prakriya highlight new research showing that STIM1 must bind to all six Orai1 subunits to effectively activate the channel.
Priscilla See-Wai Yeung, Murali Prakriya
openaire   +2 more sources

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Chronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as “secondary‐hits” believed to worsen cognitive decline.
Chang Liu, Kimia Sakha, Jaime Anton, Alfredo Cardenas‐Rivera, Mohammad A. Yaseen   +4 more
wiley   +1 more source

Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury

Function
Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated systemic inflammatory responses mediated by neutrophils.
Mengya Niu, Xiuli Zhang, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen   +11 more
doaj   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Altered TRPM3‐Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post‐COVID‐19 Condition Patients

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa, Natalie Eaton‐Fitch, Katsuhiko Muraki, Sonya Marshall‐Gradisnik   +3 more
wiley   +1 more source

Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development

Advanced Science, 2023
Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and ...
Ah Reum Lee, Chan Young Park
doaj   +1 more source

Thiol dependent intramolecular locking of Orai1 channels [PDF]

Scientific Reports, 2016
AbstractStore-operated Ca2+ entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function.
Dalia Alansary, Barbara Schmidt, Kathrin Dörr, Ivan Bogeski, Heiko Rieger, Achim Kless, Barbara A. Niemeyer   +6 more
openaire   +2 more sources