Results 81 to 90 of about 8,832 (217)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

ORAI1 mutations abolishing store-operated Ca

, 2018
BACKGROUND: Store-operated Ca OBJECTIVE: We performed molecular and immunologic analysis of patients with CID, anhidrosis, and ectodermal dysplasia of unknown etiology.
Issekutz, Thomas, Cuk, Mario, Karmen Bilic, Ehl, Stephan, Jayson Lian, Frédéric Rieux-Laucat, Kacskovics, Imre, Peter Stathopulos, Stephan Ehl, Imre Kacskovics, Vraetz, Thomas, Speckmann, Carsten, Feske, Stefan, Lina Kozhaya, Unutmaz, Derya, Lian, Jayson, Stathopulos, Peter, Melina J. Benson, Antonia Jakovcevic, Mario Cuk, Capucine Picard, Stefan Feske, Sascha Kahlfuss, Kahlfuss, Sascha, Jakovcevic, Antonia, Thomas Issekutz, Kozhaya, Lina, Carsten Speckmann, Thomas Vraetz, Benson, Melina J, Iva Martinac, Rieux-Laucat, Frédéric, Martinac, Iva, Vaeth, Martin, Martin Vaeth, Bilic, Karmen, Derya Unutmaz, Picard, Capucine   +37 more
core   +1 more source

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension

, 2022
Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure.
Hélène Le Ribeuz, Jessica Sabourin, Jean-Pierre Benitah, Bailey, MA, Ghigna, M-R, Woodhouse, Emily, Emily Woodhouse, Richard Foster, Olaf Mercier, Marc Humbert, Benitah, Jean-Pierre, Laubry, L, Dutheil, M, Masson, B, Véronique Capuano, Vincent Thomas De Montpreville, Dutheil, Mary, Antigny, Fabrice, Boët, A, Capuano, Véronique, de Montpreville, Vincent Thomas, Humbert, Marc, Montani, David, Capuano, V, Antigny, F, Sabourin, Jessica, De Montpreville, V, Ruchon, Yann, Beech, David, Fabrice Antigny, Mary Dutheil, Marc A. Bailey, Mercier, O, Angèle Boët, Ruchon, Y, Foster, R, Le Ribeuz, H, Loann Laubry, Bailey, Marc, A, David J. Beech, Mercier, Olaf, Yann Ruchon, Ghigna, Maria-Rosa, Beech, DJ, Humbert, M, Le Ribeuz, Hélène, Bastien Masson, Maria-Rosa Ghigna, Benitah, J-P, Montani, D, Foster, Richard, Woodhouse, E, Laubry, Loann, Sabourin, J, Masson, Bastien, Boët, Angèle, David Montani   +56 more
core   +1 more source

Orai1: CRACing the Th17 response in AKI [PDF]

Journal of Clinical Investigation, 2019
A strong Th17 inflammatory response aggravates ischemia reperfusion-induced (IR-induced) acute kidney injury (AKI), tissue fibrosis, and AKI-to-chronic kidney disease (CKD) progression. However, the underlying mechanisms of sustained Th17 activation following AKI and during AKI-to-CKD progression are unclear.
openaire   +2 more sources

Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure

Frontiers in Cell and Developmental Biology, 2020
The archetypal store-operated Ca2+ channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca2+ sensor stromal interaction molecule 1 (STIM1) upon Ca2+ store depletion is traditionally viewed as instrumental for the ...
Rui Luo, Ana-Maria Gomez, Jean-Pierre Benitah, Jessica Sabourin   +3 more
doaj   +1 more source

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Nature Communications, 2023
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood.
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya   +7 more
doaj   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, Volume 74, Issue S1, Page S58-S64, September 2026.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Involvement of Orai1 in tunicamycin-induced endothelial dysfunction [PDF]

The Korean Journal of Physiology & Pharmacology, 2019
Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca2+ homeostasis. The store-operated calcium (SOC) channel is the primary Ca2+ channel in non-excitable cells, but its participation in agent-induced ER stress is not clear. In this study, the effects of tunicamycin on Ca2+ influx in human umbilical vein endothelial cells (HUVECs) were ...
Yang, Hui, Xue, Yumei, Kuang, Sujuan, Zhang, Mengzhen, Chen, Jinghui, Liu, Lin, Shan, Zhixin, Lin, Qiuxiong, Li, Xiaohong, Yang, Min, Zhou, Hui, Rao, Fang, Deng, Chunyu   +12 more
openaire   +2 more sources

A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

eLife, 2020
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 ...
Priscilla S-W Yeung, Christopher E Ing, Megumi Yamashita, Régis Pomès, Murali Prakriya   +4 more
doaj   +1 more source

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long‐Term High‐Fat Diet

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar, Adebowale Adebiyi   +1 more
wiley   +1 more source