Results 101 to 110 of about 8,832 (217)

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Altered TRPM3‐Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post‐COVID‐19 Condition Patients

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post‐COVID‐19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3‐mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC ...
Chandi Tabeth Magawa, Natalie Eaton‐Fitch, Katsuhiko Muraki, Sonya Marshall‐Gradisnik   +3 more
wiley   +1 more source

TRPC channels function independently of STIM1 and Orai1 [PDF]

The Journal of Physiology, 2009
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca2+‐release activated Ca2+ (CRAC) channels, channels underlying store‐operated Ca2+ entry (SOCE). In addition, these proteins have been suggested to function in signalling and constructing other channels with biophysical properties distinct ...
Wayne I, DeHaven, Bertina F, Jones, John G, Petranka, Jeremy T, Smyth, Takuro, Tomita, Gary S, Bird, James W, Putney   +6 more
openaire   +2 more sources

Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation

Pharmaceutical Biology, 2017
Context: Spirodela polyrhiza (L.) Schleid. (Lemnaceae), Spirodelae Herba (SH), has been known to relieve inflammation, urticaria and skin symptoms including pruritus, eczema and rash.
Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, Won-Mo Yang, Hyo Sang Bae, Woo Kyung Kim   +5 more
doaj   +1 more source

Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh P. Jain, Lauren Yung, Wei‐Ting Wang, Ting Wang, Xiang Li, Angela Balistrieri, Sophia A. Ferrizzi, Cassia Pedron, Owen Brooks, Mona Alotaibi, Jian Wang, Joe G.N. Garcia, Patricia A. Thistlethwaite, Ayako Makino, Jason X.‐J. Yuan   +17 more
wiley   +1 more source

Expression of STIM1 and Orai1 in melanoma.

, 2014
(A and B) Western blot analyses of STIM1 (A) and Orai1 (B) expression in the indicated cell lines. (C) Immunohistochemical stainings of HE, MART1, STIM1 (the antibody from Abnova was used) and Orai1 (the antibody from Sigma was used) in a melanoma tissue
Lai-Hua Xie (61988), Erdene Baljinnyam (525855), Yoshihiro Ishikawa (324232), Kousaku Iwatsubo (525861), Utako Yokoyama (324208), Takayuki Fujita (324224), Ayako Makino (525859), Xianfeng Feng (525857), Stefan Feske (236350), Kayoko Oda (525858), Mizuka Iwatsubo (525860), Masanari Umemura (525854), Suzie Chen (438020), James S. Goydos (303127), Mariana S. De Lorenzo (525856)   +14 more
core   +1 more source

Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling [PDF]

Journal of General Physiology, 2015
An immunologist, asked to connect sphingomyelin and T lymphocyte signaling, would likely think first of the sphingomyelin metabolite sphingosine-1-phosphate. That thought is understandable in light of the rapid progress that has been made in studies of sphingosine-1-phosphate signaling and its ...
openaire   +2 more sources

IL-13 Regulates Orai1 Expression in Human Bronchial Smooth Muscle Cells and Airway Remodeling in Asthma Mice Model via LncRNA H19

Journal of Asthma and Allergy, 2022
Lin-Li Xiang,1,* Qian-Qian Wan,2,* Yi-Min Wang,1 Shao-Jun He,3 Wen-Juan Xu,3 Mei Ding,1,4 Jin-Jin Zhang,1,4 Yuan-Li Sun,1,4 Xiang Dong,1,4 Ying Zhou,5 Yu-Bao Cui,6 Ya-Dong Gao1,4 1Department of Allergology, Zhongnan Hospital of Wuhan University ...
Xiang LL, Wan QQ, Wang YM, He SJ, Xu WJ, Ding M, Zhang JJ, Sun YL, Dong X, Zhou Y, Cui YB, Gao YD   +11 more
doaj  

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Thiol dependent intramolecular locking of Orai1 channels [PDF]

Scientific Reports, 2016
AbstractStore-operated Ca2+ entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function.
Dalia Alansary, Barbara Schmidt, Kathrin Dörr, Ivan Bogeski, Heiko Rieger, Achim Kless, Barbara A. Niemeyer   +6 more
openaire   +2 more sources