Results 111 to 120 of about 8,832 (217)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains

Scientific Reports, 2017
Cell motility and migration requires the reorganization of the cortical cytoskeleton at the leading edge of cells and extracellular Ca2+ entry is essential for this reorganization. However the molecular nature of the regulators of this pathway is unknown.
Aida M. Lopez-Guerrero, Patricia Tomas-Martin, Carlos Pascual-Caro, Thomas Macartney, Alejandro Rojas-Fernandez, Graeme Ball, Dario R. Alessi, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero   +8 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Ryanodine Receptor Ca2+ Leak‐Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The dystrophic mdx mouse is a widely used model of Duchenne muscular dystrophy. Altered Ca2+ handling is a key feature, including increased Ca2+ leak through the ryanodine receptor (RyR1's), the primary Ca2+ release channel in skeletal muscle. Such leak has important downstream consequences for intracellular Ca2+ homeostasis.
Rhayanna B. Gaglianone, Cedric R. Lamboley, Taylor Dick, Aldo Meizoso‐Huesca, Daniel P. Singh, Bradley S. Launikonis   +5 more
wiley   +1 more source

Mutations of the ca(2+)-sensing stromal interaction molecule stim1 regulate ca(2+) influx by altered oligomerization of stim1 and by destabilization of the ca(2+) channel orai1 [PDF]

, 2013
A drop of endoplasmic reticulum Ca²⁺ concentration triggers its Ca²⁺ ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing ...
Rychkov, G., Niemeyer, B., Dörr, Kathrin, Rieger, Heiko, Rieger, H., Dorr, K., Kilch, T., Peinelt, Christine, Peinelt, C., Peglow, M., Alansary, D., Alansary, Dalia, Kilch, Tatiana, Rychkov, Grigori, Peglow, Martin, Niemeyer, Barbara A   +15 more
core   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk, Andre Zeug, Franziska E. Müller   +2 more
wiley   +1 more source

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

, 2020
Calcium flux regulating intracellular calcium levels is essential and modulated for efficient efferocytosis. However, the molecular mechanism by which calcium flux is modulated during efferocytosis remains elusive.
Susumin Yang, Lee, Gwangrog, Kwanhyeong Kim, Gayoung Kim, Deokhwan Kim, Min, Chanhyuk, Park, Daeho, Lee, Sang-Ah, Lee, Chang Sup, Moon, Hyunji, Byeongjin Moon, Yang, Susumin, Moon, Byeongjin, Kim, Kwanhyeong, Sang-Ah Lee, Kim, Gayoung, Hyunji Moon, Chanhyuk Min, Cho, Steve K., Seung-Joo Yang, Kim, Deokhwan, Yang, Seung-Joo, Juyeon Lee, Chang Sup Lee, Park, Chul-Seung, Lee, Juyeon   +25 more
core   +1 more source

STIM1, ORAI1, and KDM2B in circulating tumor cells (CTCs) isolated from prostate cancer patients

Frontiers in Cell and Developmental Biology
Introduction: Previous publications have shown that STIM1, ORAI1, and KDM2B, are implicated in Ca2+ signaling and are highly expressed in various cancer subtypes including prostate cancer.
Argyro Roumeliotou, Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Christos Stournaras, Galatea Kallergi   +5 more
doaj   +1 more source

Cross-linking the Orai1 C-termini prevents STIM1 association.

, 2015
(A) Confocal images showing expression of the Orai-YFP single and double cysteine mutants at residues L273 and L276. Whereas the single L273C and L276C mutants are expressed in the plasma membrane, the L273/276C double mutant was only found in unknown ...
Megumi Yamashita (748489), Murali Prakriya (748490), Leidamarie Tirado-Lee (748488)   +2 more
core   +1 more source

Variations in ORAI1 Gene Associated with Kawasaki Disease

PLOS ONE, 2016
Kawasaki disease (KD; MIM#61175) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD suggest possible involvement of the Ca(2+)/NFAT pathway in the pathogenesis of KD. ORAI1 is a Ca(2+) release activated Ca(2+) (CRAC) channel mediating store-operated Ca(
Yoshihiro Onouchi, Ryuji Fukazawa, Kenichiro Yamamura, Hiroyuki Suzuki, Nobuyuki Kakimoto, Tomohiro Suenaga, Takashi Takeuchi, Hiromichi Hamada, Takafumi Honda, Kumi Yasukawa, Masaru Terai, Ryota Ebata, Kouji Higashi, Tsutomu Saji, Yasushi Kemmotsu, Shinichi Takatsuki, Kazunobu Ouchi, Fumio Kishi, Tetsushi Yoshikawa, Toshiro Nagai, Kunihiro Hamamoto, Yoshitake Sato, Akihito Honda, Hironobu Kobayashi, Junichi Sato, Shoichi Shibuta, Masakazu Miyawaki, Ko Oishi, Hironobu Yamaga, Noriyuki Aoyagi, Megumi Yoshiyama, Ritsuko Miyashita, Yuji Murata, Akihiro Fujino, Kouichi Ozaki, Tomisaku Kawasaki, Jun Abe, Mitsuru Seki, Tohru Kobayashi, Hirokazu Arakawa, Shunichi Ogawa, Toshiro Hara, Akira Hata, Toshihiro Tanaka   +43 more
openaire   +4 more sources