Results 91 to 100 of about 8,832 (217)

Supra-Molecular Assemblies of ORAI1 at Rest Precede Local Accumulation into Puncta after Activation [PDF]

, 2021
The Ca2+ selective channel ORAI1 and endoplasmic reticulum (ER)-resident STIM proteins form the core of the channel complex mediating store operated Ca2+ entry (SOCE).
Niemeyer, Barbara A., Gaa, Daniel, Alansary, Dalia, de Jonge, Niels, Peckys, Diana B., Peckys, Diana B., Niemeyer, Barbara A.   +6 more
core   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury

Function
Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated systemic inflammatory responses mediated by neutrophils.
Mengya Niu, Xiuli Zhang, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen   +11 more
doaj   +1 more source

Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology, 2017
Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal.
Lei Wang, Jiaqi Hao, Yijian Zhang, Ziyi Yang, Yang Cao, Wei Lu, Yijun Shu, Lin Jiang, Yunping Hu, Wenjie Lv, Yingbin Liu, Ping Dong   +11 more
doaj   +1 more source

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells

Cells, 2020
Being the largest the Ca2+ store in mammalian cells, endoplasmic reticulum (ER)-mediated Ca2+ signalling often involves both Ca2+ release via inositol 1, 4, 5-trisphosphate receptors (IP3R) and store operated Ca2+ entries (SOCE) through Ca2+ release ...
Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L. Gill, Shengcheng Han, Youjun Wang   +11 more
doaj   +1 more source

Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice

Heliyon, 2022
Immune paralysis induced by sepsis, especially dysfunction of CD4+ T cells, leads to an increased risk of infection. In sepsis, abnormal differentiation of T lymphocytes is associated with multiorgan dysfunction syndrome.
Longwang Chen, Heliang Ke, Yaolu Zhang, Pinpin Jin, Xinyong Liu, Guangliang Hong, Guangju Zhao, Zhongqiu Lu, Bin Wu   +8 more
doaj   +1 more source

The exquisitely cooperative nature of Orai1 channel activation [PDF]

Journal of General Physiology, 2018
Yeung and Prakriya highlight new research showing that STIM1 must bind to all six Orai1 subunits to effectively activate the channel.
Priscilla See-Wai Yeung, Murali Prakriya
openaire   +2 more sources

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Chronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as “secondary‐hits” believed to worsen cognitive decline.
Chang Liu, Kimia Sakha, Jaime Anton, Alfredo Cardenas‐Rivera, Mohammad A. Yaseen   +4 more
wiley   +1 more source

Amplification of CRAC current by STIM1 and CRACM1 (Orai1) [PDF]

Nature Cell Biology, 2006
Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for ...
Christine, Peinelt, Monika, Vig, Dana L, Koomoa, Andreas, Beck, Monica J S, Nadler, Murielle, Koblan-Huberson, Annette, Lis, Andrea, Fleig, Reinhold, Penner, Jean-Pierre, Kinet   +9 more
openaire   +2 more sources

Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development

Advanced Science, 2023
Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and ...
Ah Reum Lee, Chan Young Park
doaj   +1 more source