Results 91 to 100 of about 6,378 (182)
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short‐circuit current (Isc) in the murine ileum, which was significantly reduced by extracellular Cl−, Na+, and Ca2 ...
Yunxian Wang +4 more
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STIM1, ORAI1, and KDM2B in circulating tumor cells (CTCs) isolated from prostate cancer patients
Frontiers in Cell and Developmental BiologyIntroduction: Previous publications have shown that STIM1, ORAI1, and KDM2B, are implicated in Ca2+ signaling and are highly expressed in various cancer subtypes including prostate cancer.
Argyro Roumeliotou +5 more
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Calcium-directed therapy in acute pancreatitis
Медицина неотложных состоянийBackground. Acute pancreatitis (AP) is a common and potentially life-threatening disease with high rates of complications and mortality. One of its key pathogenic mechanisms is disruption of calcium homeostasis in pancreatic acinar cells.
С.М. Чуклін, С.С. Чуклін
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NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis
Cellular Physiology and Biochemistry, 2018 Background/Aims: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with
Bingbing Zhang +7 more
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Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells
Cellular Physiology and Biochemistry, 2016 Background: Chorein, a protein encoded by VPS13A (vacuolar protein sorting-associated protein 13A), is defective in chorea acanthocytosis, a rare disease characterized by acanthocytosis of red blood cells and neuronal cell death with progressive ...
Willi Yu +9 more
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Unconjugated Bile Acids and Alcohols Inhibit Degranulation of Stimulated RBL-2H3 Cells
Frontiers in Bioscience-LandmarkBackground: Steroid hormones are widely used as anti-allergic drugs because of their potent anti-inflammatory properties and ability to suppress histamine release by 60–80%.
Michiko Yoshii +6 more
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Orai1/STIMs modulators in pulmonary vascular diseases
Cell CalciumCalcium (Ca2+) is a secondary messenger that regulates various cellular processes. However, Ca2+ mishandling could lead to pathological conditions. Orai1 is a Ca2+channel contributing to the store-operated calcium entry (SOCE) and plays a critical role in Ca2+ homeostasis in several cell types.
Anaïs Saint-Martin Willer +3 more
openaire +2 more sources
四川大学学报. 自然科学版, 2015 从小鼠脑组织中提取总RNA,RT-PCR扩增PICK1及Orai1的CDS序列,构建原核表达载体GST-PICK1及真核表达载体myc-Orai1,重组质粒经SalⅠ和NotⅠ双酶切鉴定后测序.正确的质粒myc-Orai1在HEK293细胞中表达收获过表达蛋白,GST-PICK1进行原核表达并获得融合蛋白.将纯化后的GST-PICK1蛋白条带切下,进行蛋白质液相质谱分析.后将myc-Orai1蛋白与GST-PICK1蛋白混合,进行GST-pulldown实验,western-blot检测到myc ...
蔡佩玲, 程丽佳, 王婷
doaj