Results 121 to 130 of about 8,832 (217)
ORAI1-mediated calcium influx in lactation and in breast cancer [PDF]
, 2011 The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood.
Gregory R. Monteith +21 more
core +1 more source
PGE2 potentiates Orai1-mediated calcium entry contributing to peripheral sensitization.
, 2023 Peripheral sensitization is one of the primary mechanisms underlying the pathogenesis of chronic pain. However, candidate molecules involved in peripheral sensitization remain incompletely understood.
Huo, Xiaodong +10 more
core +1 more source
Calcium-directed therapy in acute pancreatitis
Медицина неотложных состоянийBackground. Acute pancreatitis (AP) is a common and potentially life-threatening disease with high rates of complications and mortality. One of its key pathogenic mechanisms is disruption of calcium homeostasis in pancreatic acinar cells.
С.М. Чуклін, С.С. Чуклін
doaj +1 more source
NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis
, 2018 Background/Aims: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with
Cheng Xia +7 more
core +1 more source
, 2020 Store-operated calcium (Ca2+) entry is an important homeostatic mechanism in cells, whereby the release of Ca2+ from intracellular endoplasmic reticulum stores triggers the activation of a Ca2+ influx pathway.
Ralph J. Stevenson (2100556) +16 more
core +1 more source
Expression of STIM1, STIM2, and Orai1.
, 2013 A: Expression of STIM1, STIM2, Orai1, and GAPDH mRNAs detected by RT-PCR in human airway smooth muscle (ASM) cells is shown. Negative indicates a negative control.
Satoru Ito (283410) +6 more
core +1 more source
Unconjugated Bile Acids and Alcohols Inhibit Degranulation of Stimulated RBL-2H3 Cells
Frontiers in Bioscience-LandmarkBackground: Steroid hormones are widely used as anti-allergic drugs because of their potent anti-inflammatory properties and ability to suppress histamine release by 60–80%.
Michiko Yoshii +6 more
doaj +1 more source
Generation of specific anti-human Orai1 monoclonal antibody.
, 2013 A) Representation of human Orai1 tetra-membrane spanning protein with two extracellular loops of approximately 20 and 40 amino acids, respectively. B) Titration of purified monoclonal anti-Orai1 antibody binding to loop 2 peptide in ELISA assay. C) Ba/F3
John-Vu Bui (501562) +13 more
core +1 more source
ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival
, 2011 ORAI1 is a pore subunit of Ca2+ release-activated Ca2+ channels that mediate TCR stimulation-induced Ca2+ entry. A point mutation in ORAI1 (ORAI1R91W) causes SCID in human patients that is recapitulated in Orai1−/− mice, emphasizing its important role in
Sonal Srikanth +5 more
core +1 more source
STIM1 and Orai1 are expressed and functional in 16HBE cells.
, 2014 A–B, Western blots show the presence of STIM1 (A) and STIM2 (B) in 16HBE lysates. Aggregate data from 3 independent experiments are shown in B. C, RT-PCR reveals the presence of Orai transcripts. D, Averaged data are compared.
Daniel Bakowski (621895) +2 more
core +1 more source