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Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism
, 2010 et al.Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca2+) entry through plasma membrane Orai1 channels in response to decreased Ca2+ concentrations in the endoplasmic reticulum lumen. We identified an acidic motif within the STIM1 coiled-
Manjarrés, Isabel M. +1 more
core +1 more source
四川大学学报. 自然科学版, 2015 从小鼠脑组织中提取总RNA,RT-PCR扩增PICK1及Orai1的CDS序列,构建原核表达载体GST-PICK1及真核表达载体myc-Orai1,重组质粒经SalⅠ和NotⅠ双酶切鉴定后测序.正确的质粒myc-Orai1在HEK293细胞中表达收获过表达蛋白,GST-PICK1进行原核表达并获得融合蛋白.将纯化后的GST-PICK1蛋白条带切下,进行蛋白质液相质谱分析.后将myc-Orai1蛋白与GST-PICK1蛋白混合,进行GST-pulldown实验,western-blot检测到myc ...
蔡佩玲, 程丽佳, 王婷
doaj
Orai1 regulates calcium entry into dendritic spines [PDF]
Channels, 2016 Eduard, Korkotian, Menahem, Segal
openaire +2 more sources
Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases. [PDF]
Channels (Austin)Liao X, Pan C, Guo X, Cheng J.
europepmc +1 more source
The Diagnostic Journey from Rhabdomyolysis to Myopathy with Tubular Aggregates: A Family-Based Case Report and Review of the Literature. [PDF]
Pediatr RepOstojić S +9 more
europepmc +1 more source
Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart. [PDF]
Circ ResHakeem A, Revelo XS.
europepmc +1 more source
Direct targeting of ORAI1 by ginsenoside Rg3 modulates calcium signaling and senescence-associated AMPK-NRF2 activation. [PDF]
J Ginseng ResLee S, Ko M, Kwon HJ.
europepmc +1 more source
Developing Optogenetic Approaches to Study Ca<sup>2+</sup> Signaling Processes. [PDF]
Cold Spring Harb Perspect BiolNonomura T +5 more
europepmc +1 more source