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ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
Pharmaceuticals, 2023 The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators of cell function; therefore, calcium as a universal intracellular mediator is involved in very important human diseases and disorders.
Hussein N. Rubaiy
exaly +3 more sources
Notch1 regulates Orai1 and Orai3 expression in breast cancer cells [PDF]
Scientific ReportsStore-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of intracellular Ca2 ...
Joel Nieto-Felipe +9 more
doaj +2 more sources
Mechanistic insights into Orai dynamics during pore opening [PDF]
ChannelsOrai channels form highly Ca2+-selective pores in the plasma membrane (PM) and represent one of the two essential components of the Ca2+ release-activated Ca2+ (CRAC) channel.
Hadil Najjar +5 more
doaj +2 more sources
Phenotypic Heterogeneity in ORAI-1-Associated Congenital Myopathy [PDF]
Global Medical GeneticsIntroduction ORAI-1 is a plasma membrane calcium release-activated calcium channel that plays a crucial role in the excitation–contraction of skeletal muscles.
Dipti Baskar +13 more
doaj +2 more sources
Electromyography Scanning in the Diagnosis of Tension Headache [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Several attempts have been made to validate the purported aetiological mechanism after the prescribed proposal by the Ad Hoc Committee (1962), on the Classification of Headache which was recognised as muscle contraction or tension as a ...
Lata Sachan, Parth Sarthi, Namita Pal
doaj +1 more source
Cell Reports, 2021 Summary: Junctional coupling between endoplasmic reticulum (ER) Ca2+-sensor STIM proteins and plasma membrane (PM) Orai channels mediates Ca2+ signals in most cells.
James H. Baraniak, Jr. +9 more
doaj +1 more source
High affinity associations with α-SNAP enable calcium entry via Orai1 channels
PLoS ONE, 2021 Molecular steps that activate store-operated calcium entry (SOCE) via Orai channel supramolecular complex remain incompletely defined. We have earlier shown that α-SNAP regulates the on-site functional assembly and calcium selectivity of Orai1 channels ...
Ramanagouda Ramanagoudr-Bhojappa +2 more
doaj +2 more sources
Structural Insights into Ca2+ Permeation through Orai Channels
Cells, 2021 Orai channels belong to the calcium release-activated calcium (CRAC) channel family. Orai channels are responsible for the influx of extracellular Ca2+ that is triggered by Ca2+ depletion from the endoplasmic reticulum (ER); this function is essential ...
Yang Li, Xue Yang, Yuequan Shen
doaj +1 more source
Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers
Frontiers in Pharmacology, 2021 Gastroesophageal cancers, including tumors occurring in esophagus and stomach, usually have poor prognosis and lack effective chemotherapeutic drugs for treatment.
Yan Chang, Souvik Roy, Zui Pan
doaj +1 more source
STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases
Frontiers in Aging, 2022 Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse cellular functions including cell survival, metabolism, and transcription.
Helen E. Collins +2 more
doaj +1 more source