Results 11 to 20 of about 4,465 (176)
The Orai Pore Opening Mechanism [PDF]
International Journal of Molecular Sciences, 2021 Cell survival and normal cell function require a highly coordinated and precise regulation of basal cytosolic Ca2+ concentrations. The primary source of Ca2+ entry into the cell is mediated by the Ca2+ release-activated Ca2+ (CRAC) channel. Its action is stimulated in response to internal Ca2+ store depletion.
Adéla Tiffner +3 more
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Exploration of Immunology, 2023 Aim: Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of patients with AD and induces T helper 2 (Th2) immune responses and itching.
Masanori Fujii +7 more
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The Impact of Mutation L138F/L210F on the Orai Channel: A Molecular Dynamics Simulation Study
Frontiers in Molecular Biosciences, 2021 The calcium release-activated calcium channel, composed of the Orai channel and the STIM protein, plays a crucial role in maintaining the Ca2+ concentration in cells.
Xiaoqian Zhang +6 more
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Physiology, 2017 In this review article, we discuss the different gene products and translational variants of ORAI proteins and their contribution to the makeup of different native calcium-conducting channels with distinct compositions and modes of activation. We also review the different modes of regulation of these distinct calcium channels and their impact on ...
Mohamed, Trebak, James W, Putney
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Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
Biology Open, 2020 Store-operated Ca2+ entry (SOCE) is an essential Ca2+ signaling mechanism present in most animal cells. SOCE refers to Ca2+ influx that is activated by depletion of sarco/endoplasmic reticulum (S/ER) Ca2+ stores.
Courtney E. Petersen +2 more
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Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
eLife, 2021 The dimeric ER Ca2+ sensor STIM1 controls store-operated Ca2+ entry (SOCE) through the regulated binding of its CRAC activation domain (CAD) to Orai channels in the plasma membrane.
Stijn van Dorp +7 more
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Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner
Frontiers in Cell and Developmental Biology, 2021 STIM1-mediated activation of calcium selective Orai channels is fundamental for life. The three Orai channel isoforms, Orai1-3, together with their multiple ways of interplay, ensure their highly versatile role in a variety of cellular functions and ...
Adéla Tiffner +7 more
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Circulation Research, 2013 Three decades ago, Putney1 forwarded the idea of store-operated Ca2+ entry in mammalian cells. He rationalized that after the discharge of Ca2+ from an intracellular pool, an undefined signaling pathway would enhance extracellular Ca2+ influx and promote store refilling.
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Students’ Perception on The Implementation of Orai Application In CLL Method in Teaching Speaking
JEELS (Journal of English Education and Linguistics Studies), 2022 This study aims to examine EFL learners’ perception toward the application of Orai App in CLL method in teaching speaking. The study employed likert-scale questionnaires to enable researchers to collect massive data.
Halimah +2 more
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The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites
Cell Reports, 2023 Summary: Depletion of Ca2+ from the endoplasmic reticulum (ER) causes the ER Ca2+ sensor STIM1 to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM MCS, STIM1 binds to Orai channels to induce cellular Ca2+ entry.
Hadas Achildiev Cohen +4 more
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