Results 11 to 20 of about 5,913 (199)
PLoS ONE, 2013 BackgroundThe influx of extracellular Ca(2+) into mast cells is critical for the FcεR1-dependent release of preformed granule-derived mediators and newly synthesised autacoids and cytokines.
Ian Ashmole +3 more
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Physiology, 2017 In this review article, we discuss the different gene products and translational variants of ORAI proteins and their contribution to the makeup of different native calcium-conducting channels with distinct compositions and modes of activation. We also review the different modes of regulation of these distinct calcium channels and their impact on ...
Mohamed, Trebak, James W, Putney
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ORAI Ca2+ Channels in Cancers and Therapeutic Interventions
BiomoleculesThe ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling pathways.
Qian Zhang, Chen Wang, Lian He
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Structures reveal opening of the store-operated calcium channel Orai
eLife, 2018 The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma membrane of many non-excitable cells in metazoans. The channel opens in response to the depletion of Ca2+ stored in the endoplasmic reticulum (ER).
Xiaowei Hou +2 more
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Molecular understanding of calcium permeation through the open Orai channel.
PLoS Biology, 2019 The Orai channel is characterized by voltage independence, low conductance, and high Ca2+ selectivity and plays an important role in Ca2+ influx through the plasma membrane (PM).
Xiaofen Liu +9 more
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The role of proteins Stim and Orai as molecular components of the store-dependent current Ca2+ in lymphocytes [PDF]
Бюллетень сибирской медицины, 2018 In the process of evolution of eukaryotes has formatted a highly organized mechanism for maintaining and regulating intracellular calcium homeostasis, which is one of the most important components of cell signaling in all branches of the phylogenetic ...
E. V. Lychkovskaya +6 more
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The remote allosteric control of Orai channel gating.
PLoS Biology, 2019 Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth. The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered by ...
Yandong Zhou +5 more
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Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state [PDF]
, 2021 In humans, there are three paralogs of the Orai Ca2+ channel, which lie at the heart of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still being actively investigated, several artificial ...
Albano, Giuseppe +12 more
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The Orai Pore Opening Mechanism [PDF]
International Journal of Molecular Sciences, 2021 Cell survival and normal cell function require a highly coordinated and precise regulation of basal cytosolic Ca2+ concentrations. The primary source of Ca2+ entry into the cell is mediated by the Ca2+ release-activated Ca2+ (CRAC) channel. Its action is stimulated in response to internal Ca2+ store depletion.
Adéla Tiffner +3 more
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STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases
Frontiers in Aging, 2022 Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse cellular functions including cell survival, metabolism, and transcription.
Helen E. Collins +2 more
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