Results 31 to 40 of about 4,465 (176)
Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia
Pulmonary Circulation, 2020 Obstructive sleep apnea (OSA), a breathing disorder featured by chronic intermittent hypoxia (CIH) is associated with pulmonary hypertension (PH). Rodents exposed to CIH develop pulmonary vascular remodeling and PH, but the pathogenic mechanisms are not ...
Sebastian Castillo-Galán +4 more
doaj +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
The STIM/Orai coupling machinery [PDF]
Channels, 2008 Calcium (Ca(2+)) entry into non-excitable cells is mainly carried by store-operated channels (SOCs), which serve essential functions ranging from regulation of transcription to cell growth. The best-characterized store-operated current, I(CRAC), is the calcium release-activated calcium (CRAC) current initially discovered in T-lymphocytes and mast cells.
Irene, Frischauf +5 more
openaire +2 more sources
USING ORAI APPLICATION IN TEACHING PRONUNCIATION
Indonesian EFL Journal, 2019 Teaching in 4.0 era cannot be separated with Information and Communication Technology (ICT). There are many applications that can be used in learning and teaching process.
Lilis Suryani +2 more
doaj +1 more source
Functional Role of STIM-1 and Orai1 in Human Microvascular Aging
Cells, 2022 The impact of aging on vascular function is heterogeneous depending on the vascular territories. Calcium regulation plays a key role in vascular function and has been implicated in aging-related hypercontractility of corpus cavernosum.
Mariam El Assar +8 more
doaj +1 more source
Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source
The STIM1/Orai signaling machinery [PDF]
Channels, 2013 Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signaling pathway for T-cell activation as well as mast-cell degranulation. The ER-located Ca(2+)-sensor, STIM1 and the Ca(2+)-selective ion pore, Orai1 in the membrane are sufficient to fully reconstitute CRAC currents.
Fahrner, Marc +3 more
openaire +2 more sources
From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
Orai3 – the ‘exceptional’ Orai?
The Journal of Physiology, 2012 Abstract The field of agonist‐activated Ca 2+ entry in non‐excitable cells underwent a revolution some 5 years ago with the discovery of the Orai proteins as the essential pore‐forming components of the low‐conductance, highly Ca 2+
openaire +3 more sources
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site [PDF]
Nature Communications, 2014 STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane Orai Ca(2+) channels. Although they are structurally similar, we reveal critical differences in the function of the short STIM-Orai-activating regions (SOAR) of STIM1 and ...
Wang, Xizhuo +8 more
openaire +3 more sources