Results 31 to 40 of about 5,913 (199)
Molecular Biophysics of Orai Store-Operated Ca2+ Channels [PDF]
, 2015 Upon endoplasmic reticulum Ca2+ store depletion, Orai channels in the plasma membrane are activated directly by endoplasmic reticulum-resident STIM proteins to generate the Ca2+-selective, Ca2+ release-activated Ca2+ (CRAC) current.
Freites, J. Alfredo +11 more
core +1 more source
The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites
Cell Reports, 2023 Summary: Depletion of Ca2+ from the endoplasmic reticulum (ER) causes the ER Ca2+ sensor STIM1 to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM MCS, STIM1 binds to Orai channels to induce cellular Ca2+ entry.
Hadas Achildiev Cohen +4 more
doaj +1 more source
Store-independent modulation of Ca2+ entry through Orai by Septin 7
Nature Communications, 2016 Orai channels are well known to mediate store-operated calcium entry. Here authors show that in neurons of the Drosophilaflight circuit, Septin 7 acts as a negative regulator of Orai channels, surprisingly, by modulating store-independent calcium entry ...
Bipan Kumar Deb +2 more
doaj +1 more source
Store-operated calcium channels in skin
Frontiers in Physiology, 2022 The skin is a complex organ that acts as a protective layer against the external environment. It protects the internal tissues from harmful agents, dehydration, ultraviolet radiation and physical injury as well as conferring thermoregulatory control ...
Declan Manning +3 more
doaj +1 more source
Cells, 2022 Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide.
Patrick Münzer, Oliver Borst
doaj +1 more source
UTILIZING ORAI APPLICATION TO ENHANCE STUDENTS’ ENGLISH SPEAKING PERFORMANCE [PDF]
, 2023 This study aims to determine how the Orai application could improve students' speaking performance and perceptions of using it as a learning tool. The subject of this study were 40 students of one class of a public senior high school in Tangerang.
Deliza, Annisa, Sadikin, Irma Savitri
core
Frontiers in Immunology, 2022 Mast cells (MCs) are tissue resident immune cells that play important roles in the pathogenesis of allergic disorders. These responses are mediated via the cross-linking of cell surface high affinity IgE receptor (FcϵRI) by antigen resulting in calcium ...
Shaswati Chaki +8 more
doaj +1 more source
THE USE OF ORAI MOBILE APPLICATION TO TEACH SPEAKING IN EFL CLASSES [PDF]
, 2021 This paper is aimed to describe how to implement ORAI mobile application to teach speaking in EFL classes. As library research, the data were collected by analyzing articles, journals, and papers. This paper used descriptive qualitative method.
Sutami, Ni Kadek; Universitas Pendidikan Ganesha
core +2 more sources
Dissecting the mechanism of STIM coupling to Orai [PDF]
, 2011 Store-operated Ca2+ entry (SOCE) triggered by the depletion of endoplasmic reticulum (ER) luminal Ca2+ stores is a major Ca2+ entry pathway in non-excitable cells and is essential in physiological Ca2+ signaling and homeostasis. STIM proteins are sensors
Deng, Xiaoxiang
core +1 more source
Chinese Journal of Cancer, 2016 The stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) play pivotal roles in the modulation of Ca2+-regulated pathways from gene transcription to cell apoptosis ...
Jing Wen +4 more
doaj +1 more source