Results 51 to 60 of about 4,465 (176)

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Sterol hindrance of Orai activation [PDF]

Science Signaling, 2016
Cholesterol inhibits CRAC channels, which replenish intracellular stores.
Robert, Hooper, Brad S, Rothberg, Jonathan, Soboloff   +2 more
openaire   +2 more sources

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Gêneros orais

Revista Expectativa
O domínio de diferentes gêneros orais tem função importante para a construção de boas relações sociais, bem como para a atuação dos indivíduos nos diversos processos comunicativos, como trabalhar e estudar, por exemplo. Assim, o domínio da linguagem oral torna-se indispensável, tanto na vida acadêmica, quanto profissional dos discentes e futuros ...
Elissandra Belarmino da Silva, Kátia Regina Gonçalves de Deus, Francisca Janete Da Silva Adelino   +2 more
openaire   +1 more source

The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel [PDF]

, 2017
This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store ...
Aparna, Gudlur, Patrick G, Hogan
openaire   +2 more sources

Orai N-Terminus Plays a Multi-Facetted Role in Orai Gating [PDF]

Biophysical Journal, 2011
In immune cells, STIM1 and Orai1 represent the key components of Ca2+ release-activated Ca2+ channels. While the functional role of the Orai C-terminus has been extensively studied, the one of the N-terminus remains elusive. An among all Orai proteins conserved N-terminal region has been elucidated only for Orai1 to couple to STIM1 C-terminus.
Derler, Isabella, Bergsmann, Judith, Fahrner, Marc, Muik, Martin, Groschner, Klaus, Romanin, Christoph   +5 more
openaire   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Factores de risco de osteoporose feminina - Avaliação do risco segundo ORAI e realização de dexa

Revista Portuguesa de Medicina Geral e Familiar, 2005
Introdução: O “Osteoporosis Risk Assessement Instrument” (ORAI) é um método de avaliação do risco de osteoporose. A densitometria óssea por absorciometria de raios X de dupla energia (DEXA) avalia a densidade mineral óssea (DMO).
Serzelina Cunha
doaj   +1 more source