Results 51 to 60 of about 5,913 (199)
From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
Orai3 – the ‘exceptional’ Orai?
The Journal of Physiology, 2012 Abstract The field of agonist‐activated Ca 2+ entry in non‐excitable cells underwent a revolution some 5 years ago with the discovery of the Orai proteins as the essential pore‐forming components of the low‐conductance, highly Ca 2+
openaire +3 more sources
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
, 2018 Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai ...
Kim, Kyu Min +33 more
core +1 more source
Student's perception on the use of Orai application in SMPN Satu Atap Karang Nangka Rubaru Sumenep [PDF]
, 2020 Orai application is one of the android mobile applications more focuses on a range of speaking exercises such as how to reduce fillers and how to how to avoid fillers even when under pressure.
Fawaid, Anas
core +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT Although the use of AI technologies (e.g., chatbots and automated writing evaluations (AWE)) has gained considerable attention in language learning fields in recent years, how AI technologies have been designed and implemented in language learning education, as well as their effectiveness, is understudied.
Shen Qiao +2 more
wiley +1 more source
Frontiers in Physiology, 2014 Store-operated calcium (Ca2+) entry (SOCE) can be mediated by two novel proteins, STIM/Orai. We have previously demonstrated that members of the TRPC family, putative basal and store operated calcium entry channels, are present in human myometrium and ...
Evonne eChin-Smith +3 more
doaj +1 more source
Communications Biology, 2023 Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties, such as Ca2+ signaling pathways, remain unexplored.
Braxton Phillips +3 more
doaj +1 more source
The STIM/Orai coupling machinery [PDF]
Channels, 2008 Calcium (Ca(2+)) entry into non-excitable cells is mainly carried by store-operated channels (SOCs), which serve essential functions ranging from regulation of transcription to cell growth. The best-characterized store-operated current, I(CRAC), is the calcium release-activated calcium (CRAC) current initially discovered in T-lymphocytes and mast cells.
Irene, Frischauf +5 more
openaire +2 more sources
Multi-mode imaging of STIM/Orai relocalization.
, 2015 Images in each panel show EGFP-tagged Orai visualized by shadowless TIRF excitation at 488 nm (top left); mCherry-tagged STIM visualized by TIRF excitation at 532 nm (top right); mCherry-tagged STIM visualized by skimming- plane (SP) excitation at 532 nm
Ian Parker (101) +2 more
core +1 more source