Results 71 to 80 of about 5,913 (199)

Orai channels in GtoPdb v.2025.4 [PDF]

Orai channels are pore forming proteins which underlie calcium release-activated calcium (CRAC) channels. In numerous cell types, calcium influx is predominantly governed by store-operated calcium channels (SOCs).
Rubaiy, Hussein N.
core   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Orai channels in proliferation, invasion, and chemoresistance of tumor cells

Calcium signaling via store-operated calcium entry (SOCE) is critical for cellular functions implicated in cancer progression. Alterations in Orai channel isoforms, particularly Orai1 and Orai3, modulate SOCE and influence tumor cell proliferation ...
Jardín, Isaac, Macías-Diaz, Álvaro, Rosado, Juan A., Smani, Tarik, Jiménez-Velarde, Vanesa   +4 more
core   +1 more source

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling [PDF]

, 2010
Reactive oxygen species (ROS) are involved in many physiological and pathophysiological cellular processes. We used lymphocytes, which are exposed to highly oxidizing environments during inflammation, to study the influence of ROS on cellular function.
Takahashi, Nobuaki, Koehler, Richard, Bogeski, Ivan, Bozem, Monika, Koehler, R., Peinelt, Christine, Niemeyer, Barbara A., Schwarz, Eva C., Al-Ansary, Dalia, Schwarz, Eva C, Mori, Yasuo, Mori, Y., Griesemer, Desiree, Takahashi, N., Kozai, D., Griesemer, D., Kozai, Daisuke, Niemeyer, Barbara A, Hoth, Markus, Kummerow, Carsten   +19 more
core   +2 more sources

Factores de risco de osteoporose feminina - Avaliação do risco segundo ORAI e realização de dexa

Revista Portuguesa de Medicina Geral e Familiar, 2005
Introdução: O “Osteoporosis Risk Assessement Instrument” (ORAI) é um método de avaliação do risco de osteoporose. A densitometria óssea por absorciometria de raios X de dupla energia (DEXA) avalia a densidade mineral óssea (DMO).
Serzelina Cunha
doaj   +1 more source

Under‐Identification of Malnutrition Within an Inpatient Hospital Setting

Journal of Human Nutrition and Dietetics, Volume 39, Issue 5, October 2026.
ABSTRACT Introduction Malnutrition contributes to significant health and economic burden. A 2022 Malnutrition Point Prevalence Survey (PPS) at Austin Health, Melbourne, reported a 40% prevalence rate, consistent with international studies. However, despite robust screening and referral processes, 28% of at‐risk or malnourished patients were not ...
Jacqui Bailey, Jolie Baird, Olivia Dullard, Sophie Kane, Caroline J. Tuck, Katherine J. Desneves   +5 more
wiley   +1 more source

Herbal Extracts and Plant‐Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Food‐derived bioactives, herbal extracts, and standardized botanical products are being investigated as adjunctive strategies for atopic dermatitis. Their biological activity is shaped not only by plant source and nominal dose, but also by fermentation, drying, heating, extraction, food‐matrix binding, gastrointestinal transformation, and formulation ...
Muhuang Zeng, Qianlan Yuan, Shuojia Huang, Xiaofei Lu   +3 more
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source