Results 71 to 80 of about 4,465 (176)
STIM and Orai in hemostasis and thrombosis
Frontiers in Bioscience, 2011 At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion.
Attila, Braun +3 more
openaire +2 more sources
Inhibition of Orai-STIM coupling alleviates experimentally-induced airways remodeling changes
Revista Alergia México, 2018 Background: In asthma, airway remodeling changes contribute to thickening of airway walls and, consequently, lead to poor clinical outcomes among asthmatic patients.
Martina Sutovska, Sona Franova
doaj
On optimizing therapies, Orai, and ORNs [PDF]
Journal of General Physiology, 2013 This month’s installment of Generally Physiological considers individualized therapeutic strategies to treat the congenital heart condition long QT syndrome (LQTS), determination of the crystal structure of the Orai calcium channel, and nonsynaptic communication between olfactory receptor neurons (ORNs) in insect sensilla.
openaire +2 more sources
Aztarna germanikoa Euskal Herriko toponimia historikoan
Fontes Linguae Vasconum, 2001 Autoreak lan-hipotesia berri bat proposatzen du, zeinak esplika litzakeen Euskal Herriko toponimo historiko batzu orai arte “ezin esplikatuzko”-tzat ekartzen zirenak, eta hori mendebaldeko Europako lurralde batzuetan ongi dokumentatutak diren germaniar ...
Hector Iglesias
doaj +1 more source
Frontiers in Pharmacology, 2016 In the murine brain, the first post-mitotic cortical neurons formed during embryogenesis express store-operated channels (SOCs) sensitive to Pyr3, initially proposed as a blocker of transient receptor potential channel of C type 3 (TRPC3 channel ...
Sylvain Chauvet +5 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2017 Molecular components of store-operated calcium entry have been identified in the recent past and consist of the endoplasmic reticulum (ER) membrane-resident calcium sensor STIM and the plasma membrane-localized calcium channel Orai.
Trayambak Pathak +2 more
doaj +1 more source
Frontiers in Physiology, 2015 In many nonexcitable and excitable cells, store-operated calcium entry (SOCE) represents an additional pathway for calcium entry upon Ca2+ store depletion.
Jie eLiu +4 more
doaj +1 more source
Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers
Nature Communications, 2017 Store-operated calcium entry (SOCE) is elicited by the interaction of oligomerized STIM1 with plasma membrane Orai channels. Here, the authors show that this process is regulated by calmodulin, which binds STIM1 and disassembles the STIM1-Orai1 complex ...
Xin Li +8 more
doaj +1 more source
Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain
PAIN Reports. Introduction:. Acute injuries transition to chronic neuropathic pain through central sensitization (CS), which involves plastic changes to nociceptive networks within the central nervous system.
Mariya A. Prokhorenko, Jeremy T. Smyth
doaj +1 more source