Results 81 to 90 of about 5,913 (199)
, 2015 Os anticoagulantes orais são amplamente utilizados na prevenção e tratamento de doenças tromboembólicas, incluindo o tratamento da trombose venosa profunda (TVP) e o embolismo pulmonar (EP), e a prevenção dos acidentes vasculares cerebrais na fibrilhação auricular (FA).
openaire +2 more sources
STIM and Orai in hemostasis and thrombosis
Frontiers in Bioscience, 2011 At sites of vascular injury, platelets rapidly adhere to the exposed subendothelial extracellular matrix, become activated and, together with the coagulation system, form a plug that seals the lesion. This process is essential to prevent blood loss, however, under pathological conditions it may lead to vessel occlusion.
Attila, Braun +3 more
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Australian Endodontic Journal, Volume 52, Issue 2, Page 364-380, August 2026.ABSTRACT This ex vivo study characterised the mesial root morphology of mandibular first molars with a middle mesial canal (MMC) using micro‐CT. Among 469 scanned molars, 42 (8.96%) presented an MMC. Morphological parameters analysed included canal configuration, chamber orifice features, dentine thickness, isthmus type, and aspect ratio.
Nuno Rodrigues dos Santos +3 more
wiley +1 more source
Regulation of intracellular Ca2+ concentration by ORAI-2 localized on mast cell secretory granules [PDF]
, 2018 マスト細胞の分泌制御に極めて重要な役割を持つ細胞内カルシウム動態、特に分泌顆粒に局在するカルシウムチャネルORAI-2が制御する分泌メカニズムの解明を試みた。マウス耳介組織を用いた解析からORAI-2は培養細胞の分泌顆粒だけでなく、生体内マスト細胞においても分泌顆粒に同様の局在が観察された。さらに、各種バイオセンサーを用いた画像解析や生化学的な解析から、マスト細胞の抗原刺激に伴い、ORAI-2はSTIMやtubulinと相互作用を強め、ORAI ...
78894 +3 more
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Phenotypic Heterogeneity in ORAI-1-Associated Congenital Myopathy
Global Medical GeneticsIntroduction ORAI-1 is a plasma membrane calcium release-activated calcium channel that plays a crucial role in the excitation–contraction of skeletal muscles.
Dipti Baskar +13 more
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Frontiers in Cellular Neuroscience, 2014 The spatial and temporal regulation of cellular calcium signals is modulated via two main Ca2+ entry routes. Voltage-gated Ca2+ channels (VGCC) and Ca2+-release activated channels (CRAC) enable Ca2+ flow into electrically excitable and non-excitable ...
Osama F. Harraz +2 more
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Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan +6 more
wiley +1 more source
Revista ExpectativaO domínio de diferentes gêneros orais tem função importante para a construção de boas relações sociais, bem como para a atuação dos indivíduos nos diversos processos comunicativos, como trabalhar e estudar, por exemplo. Assim, o domínio da linguagem oral torna-se indispensável, tanto na vida acadêmica, quanto profissional dos discentes e futuros ...
Elissandra Belarmino da Silva +2 more
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Localization of STIM-1 and Orai-1 in DC.
, 2013 The expression of Orai-1 and STIM-1 was analyzed at the transcriptional (A and B) or translational (C) level. Quantitative RT-PCR analysis of Orai-1 (A) and STIM-1 (B) mRNA showed their expression profile for different maturating stimuli (mean ± SD). The
Jérémy Fauconnier (586768) +6 more
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Inhibition of Orai-STIM coupling alleviates experimentally-induced airways remodeling changes
Revista Alergia México, 2018 Background: In asthma, airway remodeling changes contribute to thickening of airway walls and, consequently, lead to poor clinical outcomes among asthmatic patients.
Martina Sutovska, Sona Franova
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