Results 1 to 10 of about 12,900 (288)
Role of store-operated Ca2+ entry in cardiovascular disease [PDF]
Cell Communication and Signaling, 2022 Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells.
Ting Lu +4 more
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TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes [PDF]
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
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A Reappraisal of the Effects of L-type Ca2+ Channel Blockers on Store-Operated Ca2+ Entry and Heart Failure [PDF]
Function, 2023 Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and >0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca2+ channels in resistance vessels, leading to vasodilation
Gary S Bird +5 more
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TRPV6-mediated Store-operated Ca2+ Entry Participates in Pancreatic Acinar Cell Injury During Acute PancreatitisSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Suppressing toxic Ca2+ accumulation in pancreatic acinar cells (PACs) is the central therapeutic strategy of acute pancreatitis (AP). Store-operated Ca2+ entry (SOCE) represents an important mechanism promoting Ca2+ overload, which
Chenxia Han +13 more
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Caffeine-induced Ca2+ oscillations in type I horizontal cells of the carp retina and the contribution of the store-operated Ca2+ entry pathway. [PDF]
PLoS ONE, 2014 The mechanisms of release, depletion, and refilling of endoplasmic reticulum (ER) Ca2+ were investigated in type I horizontal cells of the carp retina using a fluo-3-based Ca2+ imaging technique.
Ting Lv, Hai-Qing Gong, Pei-Ji Liang
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Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure [PDF]
Frontiers in Cell and Developmental Biology, 2020 The archetypal store-operated Ca2+ channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca2+ sensor stromal interaction molecule 1 (STIM1) upon Ca2+ store depletion is traditionally viewed as instrumental for the ...
Rui Luo +3 more
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Frontiers in Physiology, 2023 Thapsigargin (TG) inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump and, when applied acutely, it initiates a Ca2+ mobilisation that begins with the loss of Ca2+ from the endoplasmic reticulum (ER) and culminates with store-operated Ca2 ...
Tillman Pick +3 more
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Journal of Pharmacological Sciences, 2007 ATP-receptor (P2Y) stimulation induced sustained Ca2+-entry, which was essential for the enhanced cell-proliferation in t-BBEC117, an immortalized cell-line derived from bovine brain endothelial cells.
Daiju Yamazaki +3 more
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Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
Journal of Pharmacological Sciences, 2005 Lafutidine, a histamine H2 receptor antagonist, exerts gastroprotective effects in addition to gastric antisecretory activity. The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites ...
Kana Kunieda +4 more
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Shaped by leaky ER: Homeostatic Ca2+ fluxes
Frontiers in Physiology, 2022 At any moment in time, cells coordinate and balance their calcium ion (Ca2+) fluxes. The term ‘Ca2+ homeostasis’ suggests that balancing resting Ca2+ levels is a rather static process.
Annemarie Schulte +2 more
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