Results 1 to 10 of about 10,185 (153)
Role of store-operated Ca2+ entry in cardiovascular disease [PDF]
Cell Communication and Signaling, 2022 Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells.
Ting Lu +4 more
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Regulation of store-operated Ca2+ entry by Septins [PDF]
Frontiers in Cell and Developmental Biology, 2016 The mechanism of store-operated Ca2+entry (SOCE) brings extracellular Ca2+ into cells after depletion of intracellular Ca2+ stores. Regulation of Ca2+ homeostasis by SOCE helps control various intracellular signaling functions in both non-excitable and ...
Bipan Kumar Deb, Gaiti Hasan
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TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes [PDF]
Frontiers in Physiology, 2023 Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling.
Declan Manning +3 more
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Regulation of Store-Operated Ca2+ Entry by SARAF. [PDF]
Cells, 2021 Calcium (Ca2+) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca2+ entry (SOCE) by CRAC channels represents a major pathway for Ca2+ entry in non-excitable cells. The CRAC channel has two key components, the endoplasmic
Dagan I, Palty R.
europepmc +5 more sources
A Reappraisal of the Effects of L-type Ca2+ Channel Blockers on Store-Operated Ca2+ Entry and Heart Failure [PDF]
Function, 2023 Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and >0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca2+ channels in resistance vessels, leading to vasodilation
Gary S Bird +5 more
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S-acylation of Orai1 regulates store-operated Ca2+ entry. [PDF]
J Cell Sci, 2022 ABSTRACT Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca2+
West SJ +6 more
europepmc +3 more sources
Lysosomal agents inhibit store-operated Ca2+ entry. [PDF]
J Cell Sci, 2021 Pharmacological manipulation of lysosome membrane integrity or ionic movements is a key strategy for probing lysosomal involvement in cellular processes. However, we have found an unexpected inhibition of store-operated Ca2+ entry (SOCE) by these agents. Dipeptides (GPN and LLOMe) that are inducers of lysosomal membrane permeabilization (LMP) uncoupled
Morgan AJ, Galione A.
europepmc +3 more sources
Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Store-operated Ca2+ entry plays an important role in Ca2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel
Thompson M., White T., Chini E.N.
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TRPV6-mediated Store-operated Ca2+ Entry Participates in Pancreatic Acinar Cell Injury During Acute PancreatitisSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Suppressing toxic Ca2+ accumulation in pancreatic acinar cells (PACs) is the central therapeutic strategy of acute pancreatitis (AP). Store-operated Ca2+ entry (SOCE) represents an important mechanism promoting Ca2+ overload, which
Chenxia Han +13 more
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Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure [PDF]
Frontiers in Cell and Developmental Biology, 2020 The archetypal store-operated Ca2+ channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca2+ sensor stromal interaction molecule 1 (STIM1) upon Ca2+ store depletion is traditionally viewed as instrumental for the ...
Rui Luo +3 more
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