Results 31 to 40 of about 12,900 (288)

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. [PDF]

, 2006
Store-operated Ca2+ entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels following Ca2+ release from intracellular stores. We performed a genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins that inhibit store ...
Kraft, S, Kinet, J-P, Vig, M, Koomoa, D L, Fleig, A, Penner, R, Peinelt, Christine, Turner, H, Rabah, D, Beck, A, Koblan-Huberson, M   +10 more
core   +1 more source

STIM2 Is an Inhibitor of STIM1-Mediated Store-Operated Ca2+ Entry [PDF]

Current Biology, 2006
The coupling mechanism between endoplasmic reticulum (ER) Ca(2+) stores and plasma membrane (PM) store-operated channels (SOCs) remains elusive [1-3]. STIM1 was shown to play a crucial role in this coupling process [4-7]; however, the role of the closely related STIM2 protein remains undetermined.
Soboloff, Jonathan, Spassova, Maria A., Hewavitharana, Thamara, He, Li-Ping, Xu, Wen, Johnstone, Lorna S., Dziadek, Marie A., Gill, Donald L.   +7 more
openaire   +2 more sources

Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.

PLoS ONE, 2014
Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate local inflammatory responses. However, the identity of epithelial Ca2+
Krishna Samanta, Daniel Bakowski, Anant B Parekh   +2 more
doaj   +1 more source

Overexpression of SARAF Ameliorates Pressure Overload–Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction ...
Fengdan Dai, Yan Zhang, Qiang Wang, De Li, Yongjian Yang, Shuangtao Ma, Dachun Yang   +6 more
doaj   +1 more source

CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1

Cellular Physiology and Biochemistry, 2018
Background/Aims: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE).
Shu Li, Jingyi Xue, Zhipeng Sun, Tiantian Liu, Lane Zhang, Limin Wang, Hongjie You, Zheng Fan, Yuanyuan Zheng, Dali Luo   +9 more
doaj   +1 more source

Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington’s Disease

Frontiers in Cell and Developmental Biology, 2021
One of the major Ca2+ signaling pathways is store-operated Ca2+ entry (SOCE), which is responsible for Ca2+ flow into cells in response to the depletion of endoplasmic reticulum Ca2+ stores.
Ewelina Latoszek, Magdalena Czeredys
doaj   +1 more source

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
Heinemann, Akos, Zoltán Bálint, Akos Heinemann, György Váró (417636), Végh Attila G., Fazakas Csilla, Olschewski Horst, Csilla Fazakas, Krizbai István A., Horst Olschewski, Heinemann Akos, Konya, Viktoria, Diana Zabini, Chandran Nagaraj, Nagaraj Chandran, Váró, György, Bálint Zoltán, Zoltán Bálint (142590), Zabini, Diana, György Váró, Andrea Olschewski, Csilla Fazakas (218764), Akos Heinemann (142582), Olschewski Andrea, Attila G Végh, Olschewski, Horst, Chandran Nagaraj (142558), Bálint, Zoltán, István A Krizbai, István A. Krizbai (218814), Imola Wilhelm (218768), Andrea Olschewski (142595), Fazakas, Csilla, Viktoria Konya, Diana Zabini (142555), Attila G. Végh (417635), Viktoria Konya (176778), Váró György, Krizbai, István Adorján, Wilhelm Imola, Horst Olschewski (142585), Zabini Diana, Konya Viktoria, Olschewski, Andrea, Végh, Attila Gergely, Imola Wilhelm, Wilhelm, Imola   +46 more
core   +1 more source

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]

PLoS ONE, 2014
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor   +2 more
doaj   +1 more source

STIMulating store-operated Ca2+ entry [PDF]

Nature Cell Biology, 2009
Calcium influx through plasma membrane store-operated Ca(2+) (SOC) channels is triggered when the endoplasmic reticulum (ER) Ca(2+) store is depleted - a homeostatic Ca(2+) signalling mechanism that remained enigmatic for more than two decades. RNA-interference (RNAi) screening and molecular and cellular physiological analysis recently identified STIM1
openaire   +2 more sources

Data on cytotoxicity in HeLa and SU-DHL-4 cells exposed to DPB162-AE compound

Data in Brief, 2017
DPB162-AE is a valuable tool to study store-operated Ca2+ entry (SOCE), as this compound was developed as a 2-APB analog that inhibits SOCE more potently and more selectively than 2-APB itself.
Mart Bittremieux, Katsuhiko Mikoshiba, Geert Bultynck   +2 more
doaj   +1 more source