Results 31 to 40 of about 10,284 (252)
Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]
PLoS ONE, 2014 Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo +2 more
doaj +1 more source
STIMulating store-operated Ca2+ entry [PDF]
Nature Cell Biology, 2009 Calcium influx through plasma membrane store-operated Ca(2+) (SOC) channels is triggered when the endoplasmic reticulum (ER) Ca(2+) store is depleted - a homeostatic Ca(2+) signalling mechanism that remained enigmatic for more than two decades. RNA-interference (RNAi) screening and molecular and cellular physiological analysis recently identified STIM1
openaire +2 more sources
Data on cytotoxicity in HeLa and SU-DHL-4 cells exposed to DPB162-AE compound
Data in Brief, 2017 DPB162-AE is a valuable tool to study store-operated Ca2+ entry (SOCE), as this compound was developed as a 2-APB analog that inhibits SOCE more potently and more selectively than 2-APB itself.
Mart Bittremieux +2 more
doaj +1 more source
Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy
Frontiers in Pharmacology, 2017 Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues.
Xiaoqiang Yao +18 more
doaj +1 more source
Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
Frontiers in Cell and Developmental Biology, 2020 Huntington's disease (HD) is a progressive neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric problems. It is caused by a polyglutamine expansion in the huntingtin protein that leads to striatal degeneration via the ...
Magdalena Czeredys
doaj +1 more source
IP3 receptors and store-operated Ca2+ entry: a license to fill [PDF]
Current Opinion in Cell Biology, 2019 Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular Ca2+ channels that evoke large local increases in cytosolic Ca2+ concentration. By depleting the ER of Ca2+, IP3Rs also activate store-operated Ca2+ entry (SOCE). Immobile IP3Rs close to the plasma membrane (PM) are the only IP3Rs that respond to physiological stimuli ...
Taylor, Colin W, Machaca, Khaled
openaire +3 more sources
Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
eLife, 2019 Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca2 ...
Antonio Michelucci +7 more
doaj +1 more source
Store-operated Ca2+ entry supports contractile function in hearts of hibernators. [PDF]
PLoS ONE, 2017 Hibernators have a distinctive ability to adapt to seasonal changes of body temperature in a range between 37°C and near freezing, exhibiting, among other features, a unique reversibility of cardiac contractility.
Olga V Nakipova +10 more
doaj +1 more source
Arachidonic acid-induced Ca2+ entry and migration in a neuroendocrine cancer cell line
Cancer Cell International, 2018 Background Store-operated Ca2+ entry (SOCE) has been implicated in the migration of some cancer cell lines. The canonical SOCE is defined as the Ca2+ entry that occurs in response to near-maximal depletion of Ca2+ within the endoplasmic reticulum ...
Priyodarshan Goswamee +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source