Results 41 to 50 of about 12,900 (288)
, 2020 Metabolic syndrome causes adverse effects on the coronary circulation including altered vascular responsiveness and the progression of coronary artery disease (CAD). However the underlying mechanisms linking obesity with CAD are intricated.
Sánchez Pina, Ana Alejandra +7 more
core +1 more source
IP3 receptors and store-operated Ca2+ entry: a license to fill [PDF]
Current Opinion in Cell Biology, 2019 Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular Ca2+ channels that evoke large local increases in cytosolic Ca2+ concentration. By depleting the ER of Ca2+, IP3Rs also activate store-operated Ca2+ entry (SOCE). Immobile IP3Rs close to the plasma membrane (PM) are the only IP3Rs that respond to physiological stimuli ...
Taylor, Colin W, Machaca, Khaled
openaire +3 more sources
Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy
Frontiers in Pharmacology, 2017 Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues.
Xiaoqiang Yao +18 more
doaj +1 more source
Emerging perspectives in store-operated Ca2+ entry: Roles of Orai, Stim and TRP [PDF]
, 2006 Depletion of intracellular Ca2+ stores induces Ca2+ influx across the plasma membrane through store-operated channels (SOCs). This store-operated Ca2+ influx is important for the replenishment of the Ca2+ stores, and is also involved in many signaling ...
Mercer, Jason C. +13 more
core +1 more source
Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
Frontiers in Cell and Developmental Biology, 2020 Huntington's disease (HD) is a progressive neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric problems. It is caused by a polyglutamine expansion in the huntingtin protein that leads to striatal degeneration via the ...
Magdalena Czeredys
doaj +1 more source
Orai1 mediates store-operated Ca2+ entry during fertilization in mammalian oocytes [PDF]
, 2012 The presence of the store-operated Ca2+ entry channel Orai1 and its function in signal transduction during fertilization have been investigated in mammalian oocytes using the pig as a model.
Gajdócsi, Erzsébet +4 more
core +1 more source
Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
eLife, 2019 Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca2 ...
Antonio Michelucci +7 more
doaj +1 more source
Store-operated Ca2+ entry supports contractile function in hearts of hibernators. [PDF]
PLoS ONE, 2017 Hibernators have a distinctive ability to adapt to seasonal changes of body temperature in a range between 37°C and near freezing, exhibiting, among other features, a unique reversibility of cardiac contractility.
Olga V Nakipova +10 more
doaj +1 more source
Hydrogen peroxide activates store-operated Ca2+ entry in coronary arteries
, 2015 BACKGROUND AND PURPOSE Abnormal Ca2+ metabolism has been involved in the pathogenesis of vascular dysfunction associated with oxidative stress. Here, we have investigated the actions of H2O2 on store-operated Ca2+ (SOC) entry in coronary arteries and ...
Muñoz Picos, Mercedes +5 more
core +1 more source
Ca2+-independent Phospholipase A2 Is a Novel Determinant of Store-operated Ca2+ Entry [PDF]
Journal of Biological Chemistry, 2003 Store-operated cation (SOC) channels and capacitative Ca(2+) entry (CCE) play very important role in cellular function, but the mechanism of their activation remains one of the most intriguing and long lasting mysteries in the field of Ca(2+) signaling.
Tarik, Smani +5 more
openaire +2 more sources