Results 61 to 70 of about 10,284 (252)

Notch1 regulates Orai1 and Orai3 expression in breast cancer cells

Scientific Reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of intracellular Ca2 ...
Joel Nieto-Felipe, Alvaro Macias-Diaz, Sandra Alvarado, Pedro C. Redondo, Vanesa Jimenez-Velarde, Jose J. Lopez, Astrid Gorischek, Isaac Jardin, Tarik Smani, Juan A. Rosado   +9 more
doaj   +1 more source

Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration.

PLoS ONE, 2014
Store-operated Ca(2+) entry (SOCE) is a major mechanism of Ca(2) (+) import from extracellular to intracellular space, involving detection of Ca(2+) store depletion in endoplasmic reticulum (ER) by stromal interaction molecule (STIM) proteins, which then
Masanari Umemura, Erdene Baljinnyam, Stefan Feske, Mariana S De Lorenzo, Lai-Hua Xie, Xianfeng Feng, Kayoko Oda, Ayako Makino, Takayuki Fujita, Utako Yokoyama, Mizuka Iwatsubo, Suzie Chen, James S Goydos, Yoshihiro Ishikawa, Kousaku Iwatsubo   +14 more
doaj   +1 more source

Exploration of thioridazine-induced Ca2+ signaling and non-Ca2+-triggered cell death in HepG2 human hepatocellular carcinoma cells

Chinese Journal of Physiology, 2020
Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca2+ concentration ([Ca2+]i) and viability in human liver cancer cells is unclear.
I-Shu Chen, Wei-Zhe Liang, Jue-Long Wang, Chun-Chi Kuo, Lyh-Jyh Hao, Chiang-Ting Chou, Chung-Ren Jan   +6 more
doaj   +1 more source

A‐Site High‐Entropy Perovskite Enabling Sulfur‐Tolerant and Coking‐Resistant Anodes for Hydrocarbon‐Fueled Solid Oxide Fuel Cells

Advanced Materials, EarlyView.
A‐site high‐entropy engineering creates a robust Pr0.2Ba0.2La0.2Sr0.2Ca0.2FeO3‐δ (PBLSCF) perovskite‐based solid oxide fuel cell (SOFC) anode with in situ Fe nanoparticle exsolution to boost fuel oxidation and durability, achieving strong sulfur tolerance and coking resistance.
Lei Wu, Yue Bao, Zhi‐Hao Wang, Haixia Li, John Meynard M. Tengco, Ramin Babazadeh Dizaj, Patrick Holcombe, Roozbeh Seifollahy Astaraee, Nathan Thornburg, Chuancheng Duan, Fanglin Chen   +10 more
wiley   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels

Biological Research, 2008
Neurons are a diverse cell type exhibiting hugely different morphologies and neurotransmitter specifications. Their distinctive phenotypes are established during differentiation from pluripotent precursor cells.
PAUL CUDDON, MARTIN D BOOTMAN, GILLIAN R RICHARDS, ALISON J SMITH, PETER B SIMPSON, H LLEWELYN RODERICK   +5 more
doaj  

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation

Cellular Physiology and Biochemistry, 2016
Background/Aims: Stromal interacting molecule-1 (STIM1) aggregation and redistribution to plasma membrane to interact with Orai1 constitute the core mechanism of store-operated Ca2+ entry (SOCE).
Lane Zhang, Limin Wang, Shu Li, Jingyi Xue, Dali Luo   +4 more
doaj   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Up-Regulation of Na+/Ca2+ Exchange in Megakaryocytes Following TGFβ1 Treatment

Cellular Physiology and Biochemistry, 2016
Background: Blood platelets are activated by increase of cytosolic Ca2+ activity ([Ca2+]i). Ca2+ entry is accomplished in part by store operated Ca2+ entry (SOCE) involving Ca2+ release activated Ca2+-channel (CRAC) moiety Orai1 and its regulator STIM1 ...
Ahmad Almilaji, Jing Yan, Zohreh Hosseinzadeh, Evi Schmid, Meinrad Gawaz, Florian Lang   +5 more
doaj   +1 more source