Results 71 to 80 of about 12,900 (288)

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

EB1 traps STIM1 and regulates local store-operated Ca2+ entry

, 2018
STIM1 activates store-operated Ca2+ entry when Ca2+ in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER
Tie-Shan Tang, Qiao-Chu Wang, Xi Wang
core   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Expanding the store-operated Ca2+ entry microdomain through Ca2+ tunneling

Current Opinion in Physiology, 2020
Ca2+ is unique among second messenger in terms of its spatial and temporal breadth. On the spatial level Ca2+ signals extend from nm to cm scales (seven orders of magnitude), and in the temporal dimension it signals in the range of μsec to hours (nine orders of magnitude).
Raphael J Courjaret, Khaled Machaca
openaire   +1 more source

Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs [PDF]

Cell Calcium, 2017
Repetitive oscillations in cytoplasmic Ca2+ due to periodic Ca2+ release from the endoplasmic reticulum (ER) drive mammalian embryo development following fertilization. Influx of extracellular Ca2+ to support the refilling of ER stores is required for sustained Ca2+ oscillations, but the mechanisms underlying this Ca2+ influx are controversial ...
Miranda L, Bernhardt, Elizabeth, Padilla-Banks, Paula, Stein, Yingpei, Zhang, Carmen J, Williams   +4 more
openaire   +2 more sources

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells [PDF]

The Journal of Immunology, 2015
Abstract Store-operated Ca2+ entry (SOCE) through Ca2+ release–activated Ca2+ (CRAC) channels is essential for immunity to infection. CRAC channels are formed by ORAI1 proteins in the plasma membrane and activated by stromal interaction molecule (STIM)1 and STIM2 in the endoplasmic reticulum.
Vaeth, Martin, Zee, Isabelle, Concepcion, Axel R, Maus, Mate, Shaw, Patrick, Portal-Celhay, Cynthia, Zahra, Aleena, Kozhaya, Lina, Weidinger, Carl, Philips, Jennifer, Unutmaz, Derya, Feske, Stefan   +11 more
openaire   +2 more sources

Notch1 regulates Orai1 and Orai3 expression in breast cancer cells

Scientific Reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of intracellular Ca2 ...
Joel Nieto-Felipe, Alvaro Macias-Diaz, Sandra Alvarado, Pedro C. Redondo, Vanesa Jimenez-Velarde, Jose J. Lopez, Astrid Gorischek, Isaac Jardin, Tarik Smani, Juan A. Rosado   +9 more
doaj   +1 more source

Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration.

PLoS ONE, 2014
Store-operated Ca(2+) entry (SOCE) is a major mechanism of Ca(2) (+) import from extracellular to intracellular space, involving detection of Ca(2+) store depletion in endoplasmic reticulum (ER) by stromal interaction molecule (STIM) proteins, which then
Masanari Umemura, Erdene Baljinnyam, Stefan Feske, Mariana S De Lorenzo, Lai-Hua Xie, Xianfeng Feng, Kayoko Oda, Ayako Makino, Takayuki Fujita, Utako Yokoyama, Mizuka Iwatsubo, Suzie Chen, James S Goydos, Yoshihiro Ishikawa, Kousaku Iwatsubo   +14 more
doaj   +1 more source

Store-operated Ca2+ entry in first trimester and term human placenta

, 2003
We have examined whether store-operated Ca2+ entry, a common pathway for Ca2+ entry in non-excitable tissue, is apparent in the syncytiotrophoblast of both first trimester and term human placenta.
B. Hamark, A. C. Elliott, Hamark, B., L. H. Clarson, Elliott, A. C.; id_orcid, Powell, T., T. Powell, V. H. J. Roberts, Clarson, L. H., Roberts, V. H J   +9 more
core   +1 more source