Results 1 to 10 of about 191,454 (167)

INTRACELLULAR Ca2+ HOMEOSTASIS

Malang Neurology Journal, 2015
Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the ...
Shahdevi Nandar Kurniawan
doaj   +3 more sources

Mitochondrial Ca²⁺ homeostasis in trypanosomes. [PDF]

Int Rev Cell Mol Biol, 2021
Mitochondrial calcium ion (Ca2+) uptake is important for buffering cytosolic Ca2+ levels, for regulating cell bioenergetics, and for cell death and autophagy. Ca2+ uptake is mediated by a mitochondrial Ca2+ uniporter (MCU) and the discovery of this channel in trypanosomes has been critical for the identification of the molecular nature of the channel ...
Docampo R, Vercesi AE, Huang G, Lander N, Chiurillo MA, Bertolini M.   +5 more
europepmc   +3 more sources

AS160 is a lipid-responsive regulator of cardiac Ca2+ homeostasis by controlling lysophosphatidylinositol metabolism and signaling [PDF]

Nature Communications
The obese heart undergoes metabolic remodeling and exhibits impaired calcium (Ca2+) homeostasis, which are two critical assaults leading to cardiac dysfunction. The molecular mechanisms underlying these alterations in obese heart are not well understood.
Shu Su, Chao Quan, Qiaoli Chen, Ruizhen Wang, Qian Du, Sangsang Zhu, Min Li, Xinyu Yang, Ping Rong, Jiang Chen, Yingyu Bai, Wen Zheng, Weikuan Feng, Minjun Liu, Bingxian Xie, Kunfu Ouyang, Yun Stone Shi, Feng Lan, Xiuqin Zhang, Ruiping Xiao, Xiongwen Chen, Hong-Yu Wang, Shuai Chen   +22 more
doaj   +2 more sources

TRPC3 Channel Activity and Viability of Purkinje Neurons can be Regulated by a Local Signalosome

Frontiers in Molecular Biosciences, 2022
Canonical transient receptor potential channels (TRPC3) may play a pivotal role in the development and viability of dendritic arbor in Purkinje neurons. This is a novel postsynaptic channel for glutamatergic synaptic transmission.
Naveed Aslam, Farah Alvi, Farah Alvi
doaj   +1 more source

OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling

Frontiers in Cell and Developmental Biology, 2022
Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae ...
Benjamín Cartes-Saavedra, Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E. Andrés, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner   +11 more
doaj   +1 more source

FERONIA-like receptor 1-mediated calcium ion homeostasis is involved in the immune response

Frontiers in Plant Science, 2022
Calcium (Ca2+) is the most abundant divalent cation in plants, and cellular levels of Ca2+, which functions as a nutrient and secondary messenger, play a critical role in plant immunity.
Xiao Luo, Xiao Luo, Long Wang, Long Wang, Yuefeng Fu, Qiqi Liu, Ge Chen, Yue Liu, Yue Liu, Wei He, Aijun Gao, Jingbo Xu, Huafeng Deng, Junjie Xing   +13 more
doaj   +1 more source

Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis [PDF]

Journal of Biological Chemistry, 2012
Intracellular free Ca(2+) ions regulate many cellular functions, and in turn, the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca(2+). Here, we review recent work on Ca(2+)-dependent mechanisms and effectors that regulate the transcription of genes encoding proteins involved in the maintenance of the ...
Jose R, Naranjo, Britt, Mellström
openaire   +2 more sources

Kinetics of the thapsigargin-induced Ca2+ mobilisation: A quantitative analysis in the HEK-293 cell line

Frontiers in Physiology, 2023
Thapsigargin (TG) inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump and, when applied acutely, it initiates a Ca2+ mobilisation that begins with the loss of Ca2+ from the endoplasmic reticulum (ER) and culminates with store-operated Ca2 ...
Tillman Pick, Igor Gamayun, René Tinschert, Adolfo Cavalié   +3 more
doaj   +1 more source

Mitochondrial Ca2+ homeostasis in intact cells. [PDF]

The Journal of cell biology, 1994
Ca2+ is a key regulator not only of multiple cytosolic enzymes, but also of a variety of metabolic pathways occurring within the lumen of intracellular organelles. Until recently, no technique to selectively monitor the Ca2+ concentration within defined cellular compartments was available.
RIZZUTO, ROSARIO, BASTIANUTTO C, BRINI, MARISA, MURGIA, MARTA, POZZAN, TULLIO   +4 more
openaire   +4 more sources

Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2020
There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas disease, potential therapeutic targets have been identified by exploiting the ...
Gustavo Benaim, Gustavo Benaim, Alberto E. Paniz-Mondolfi, Alberto E. Paniz-Mondolfi, Emilia Mia Sordillo, Emilia Mia Sordillo, Nathalia Martinez-Sotillo   +6 more
doaj   +1 more source