Mechanism of Ca2+ transport by ferroportin
eLife, 2023 Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe2+) from cells and is important for homeostasis of iron in circulation. Export of one Fe2+ by Fpn is coupled to import of two H+ to maintain charge balance.
Jiemin Shen +3 more
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The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability [PDF]
Nature, 2017 Mitochondrial calcium (mCa2+) has a central role in both metabolic regulation and cell death signalling, however its role in homeostatic function and disease is controversial. Slc8b1 encodes the mitochondrial Na+/Ca2+ exchanger (NCLX), which is proposed to be the primary mechanism for mCa2+ extrusion in excitable cells.
Timothy S, Luongo +15 more
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Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]
, 2013 Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
Heinemann, Akos +46 more
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Calcium Homeostasis in ageing neurons
Frontiers in Genetics, 2012 The nervous system becomes increasingly vulnerable to insults and prone to dysfunction during ageing. Age-related decline of neuronal function is manifested by the late onset of many neurodegenerative disorders, as well as by reduced signalling and ...
Vassiliki eNikoletopoulou +1 more
doaj +1 more source
The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis
Frontiers in Cell and Developmental Biology, 2021 Brain disorders include neurodegenerative diseases (NDs) with different conditions that primarily affect the neurons and glia in the brain. However, the risk factors and pathophysiological mechanisms of NDs have not been fully elucidated.
Sung-Min Hwang +3 more
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The self-maintaining nature of ventricular fibrillation : contribution of L-type Ca²+ channels and Na+/Ca²+ exchange to cardiomyocyte Ca²+ overload in ventricular fibrillation : surface fluorescence study in isolated perfused rat hearts [PDF]
, 2004 Approximately 40% of all deaths in Switzerland are due to cardiovascular diseases.1 An important part of these deaths happen because of life-threatening cardiac arrhythmias.
Driamov, Sergey
core +1 more source
Role of PKD2 in the endoplasmic reticulum calcium homeostasis
Frontiers in Physiology, 2022 Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 or PKD2 gene which encodes membrane receptor PKD1 and cation channel PKD2, respectively. PKD2, also called transient receptor potential polycystin-2 (TRPP2), is a Ca2+
Xiong Liu, Jingfeng Tang, Xing-Zhen Chen
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Susceptibility to calcium dysregulation during brain aging
Frontiers in Aging Neuroscience, 2009 Calcium (Ca2+) is a highly versatile intracellular signaling molecule that is essential for regulating a variety of cellular and physiological processes ranging from fertilization to programmed cell death.
Ashok Kumar
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The mitochondrial permeability transition pore in Ca2+ homeostasis
Cell Calcium, 2023 The mitochondrial Permeability Transition Pore (PTP) can be defined as a Ca2+ activated mega-channel involved in mitochondrial damage and cell death, making its inhibition a hallmark for therapeutic purposes in many PTP-related paradigms. Although long-lasting PTP openings have been widely studied, the physiological implications of transient openings ...
Michela Carraro, Paolo Bernardi
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Energy imbalance alters Ca2+ handling and excitability of POMC neurons
eLife, 2017 Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis.
Lars Paeger +8 more
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