Results 51 to 60 of about 10,284 (252)

Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells [PDF]

The Journal of Immunology, 2015
Abstract Store-operated Ca2+ entry (SOCE) through Ca2+ release–activated Ca2+ (CRAC) channels is essential for immunity to infection. CRAC channels are formed by ORAI1 proteins in the plasma membrane and activated by stromal interaction molecule (STIM)1 and STIM2 in the endoplasmic reticulum.
Vaeth, Martin, Zee, Isabelle, Concepcion, Axel R, Maus, Mate, Shaw, Patrick, Portal-Celhay, Cynthia, Zahra, Aleena, Kozhaya, Lina, Weidinger, Carl, Philips, Jennifer, Unutmaz, Derya, Feske, Stefan   +11 more
openaire   +2 more sources

Mineral Deposition From Liquid Precursors Triggered by Complementary Polyelectrolytes

Advanced Functional Materials, EarlyView.
Polyelectrolyte additives can delay or prevent crystal nucleation in supersaturated solutions of insoluble mineral salts such as calcium carbonate. This work reports that adding a second, oppositely‐charged polyelectrolyte leads to immediate mineral crystallization from such metastable solutions.
Mohammed Kayes Patoary, Eli Halperin Pierce, Elizabeth Siu, Brigitte Gallagher, Md Abul Shahid, Yang Zhang, Thomas B. H. Schroeder   +6 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

STIM and Orai1 variants in store-operated calcium entry

Frontiers in Pharmacology, 2016
Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM ...
JUAN ANTONIO ROSADO, Raquel eDiez, Tarik eSmani, Isaac eJardin   +3 more
doaj   +1 more source

TRP: Its Role in Phototransduction and Store-Operated Ca2+ Entry [PDF]

Cell, 1996
Perhaps the best characterized SOC is the CRAC (Ca2+-release activated Ca2+) channel described in several cell types, including mast cells (Hoth and Penner 1992xHoth, M and Penner, R. Nature. 1992; 355: 353–356Crossref | PubMed | Scopus (1131)See all ReferencesHoth and Penner 1992) and T lymphocytes (Zweifach and Lewis 1993xZweifach, A and Lewis, R.S ...
openaire   +2 more sources

Expanding the store-operated Ca2+ entry microdomain through Ca2+ tunneling

Current Opinion in Physiology, 2020
Ca2+ is unique among second messenger in terms of its spatial and temporal breadth. On the spatial level Ca2+ signals extend from nm to cm scales (seven orders of magnitude), and in the temporal dimension it signals in the range of μsec to hours (nine orders of magnitude).
Raphael J Courjaret, Khaled Machaca
openaire   +1 more source

Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs [PDF]

Cell Calcium, 2017
Repetitive oscillations in cytoplasmic Ca2+ due to periodic Ca2+ release from the endoplasmic reticulum (ER) drive mammalian embryo development following fertilization. Influx of extracellular Ca2+ to support the refilling of ER stores is required for sustained Ca2+ oscillations, but the mechanisms underlying this Ca2+ influx are controversial ...
Miranda L, Bernhardt, Elizabeth, Padilla-Banks, Paula, Stein, Yingpei, Zhang, Carmen J, Williams   +4 more
openaire   +2 more sources

Opportunities of Semiconducting Oxide Nanostructures as Advanced Luminescent Materials in Photonics

Advanced Materials, EarlyView.
The review discusses the challenges of wide and ultrawide bandgap semiconducting oxides as a suitable material platform for photonics. They offer great versatility in terms of tuning microstructure, native defects, doping, anisotropy, and micro‐ and nano‐structuring. The review focuses on their light emission, light‐confinement in optical cavities, and
Ana Cremades, Pedro Hidalgo, David Maestre, Ruth Martínez‐Casado, Emilio Nogales, Beatriz Rodríguez, G. Cristian Vásquez, Bianchi Méndez   +7 more
wiley   +1 more source

Store-operated Ca2+ Entry and Coupling to Ca2+ Pool Depletion in Thapsigargin-resistant Cells [PDF]

Journal of Biological Chemistry, 1997
The release of Ca2+ from intracellular Ca2+ pumping pools and the entry of extracellular Ca2+ are tightly coupled events. The potent and specific intracellular Ca2+ pump inhibitor, thapsigargin, blocks Ca2+ accumulation and allows Ca2+ release from pools within mammalian cells, inducing major changes in endoplasmic reticulum function and cell growth ...
R T, Waldron, A D, Short, D L, Gill
openaire   +2 more sources

Bubble Formation Control: Fabrication of Centimeter‐Sized Tissue‐Like Constructs by Catalase‐Coated Oxygen‐Releasing Hydrogel

Advanced Materials, EarlyView.
Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon, Isabel F. Amaral, Ana P. Pêgo, Michiya Matsusaki   +3 more
wiley   +1 more source